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Registry of Toxic Effects of Chemical Substances (RTECS)

s-Triazole

RTECS #

XZ3806000

CAS #

288-88-0; 288-89-1

Updated

October 2010

Molecular Weight

69.08

Molecular Formula

C2H3N3

Synonyms

1H-1,2,4-Triazole (9CI)
TA

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 12%GISAAA 51(11),65,1986
eye /rabbit 50 mg severeHPV426 -,-,2009
skin /rabbit 25%GISAAA 51(11),65,1986
skin /rabbit 0.5 gm mildHPV426 -,-,2009

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 10500 mg/kg (multigeneration)Reproductive: Other effects on male

Reproductive: Other effects on female

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
HPV426 -,-,2009
oral/rat 1000 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV426 -,-,2009
oral/rabbit 1035 mg/kg (6-28D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
HPV426 -,-,2009

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 1350 mg/kgBehavioral: Tremor

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 51(11),65,1986
oral/quail lethal dose (50 percent kill): >316 mg/kgEESADV 6,149,1982
oral/rat lethal dose (50 percent kill): 1375 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
HPV426 -,,2009
oral/rat lethal dose (50 percent kill): 1750 mg/kgBehavioral: Tremor

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 51(11),65,1986
skin/rabbit lowest published lethal dose: 2000 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
HPV426 -,,2009
skin/rat lethal dose (50 percent kill): 3129 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
HPV426 -,,2009

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 32400 mg/kg/90D- intermittentBehavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
HPV426 -,-,2009
oral/mouse lowest published toxic dose: 6720 mg/kg/28D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductHPV426 -,-,2009
oral/rat lowest published toxic dose: 364 mg/kg/26W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Kidney, Ureter, and Bladder: Proteinuria
GISAAA 51(11),65,1986
oral/rat lowest published toxic dose: 11250 mg/kg/90D- intermittentBehavioral: Convulsions or effect on seizure threshold

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV426 -,-,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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