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s - Triazine - 2,4,6 (1H,3H,5H) - trione, 1,3,5 - tris (2,3 - epoxypropyl) -

RTECS #: XZ1994900

CAS #: 2451-62-9


UPDATE: May 2009 MW: 297.30 MF: C12H15N3O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,3,5 - Triazine - 2,4,6 (1H,3H,5H) - trione, 1,3,5 - tris (oxiranemethyl) - (9CI)
  2. 1,3,5 - Triglycidyl isocyanurate
  3. 1,3,5 - Triglycidyl - s - triazinetrione
  4. 1,3,5 - Triglycidylisocyanuric acid
  5. 1,3,5 - Tris (oxiranylmethyl) - 1,3,5 - triazine - 2,4,6 (1H,3H,5H) - trione
  6. Araldite PT 810
  7. Glycidyl isocyanurate
  1. N,N',N'' - Triglycidyl isocyanurate
  2. TGT
  3. Triglycidyl isocyanurate
  4. Tris (2,3 - epoxypropyl) isocyanurate
  5. Tris (epoxypropyl) isocyanurate
  6. s - Triazine - 2,4,6 (1H,3H,5H) - trione, 1,3,5 - tris (2,3 - epoxypropyl) - (8CI)
  7. s - Triazine - 2,4,6 (1H,3H,5H) - trione, tris (2,3 - epoxypropyl) -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 1,200 g/L MUREAV 241,175,1990
cytogenetic analysis oral
mouse
4 gm/kg/5 day- continuous EPASR* 8EHQ-0491-0490
mutation in microorganisms Salmonella typhimurium 333 g/plate (+enzymatic activation step) EMMUEG 19(Suppl 21),2,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 2 gm/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** OTS0555023


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lethal dose (50 percent kill): 188 mg/kg Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
NTIS** OTS0555027


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 0.08 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3, Carcinogen, MAR2002
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.08 mg/m3, JAN2002
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8890
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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