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Registry of Toxic Effects of Chemical Substances (RTECS)

s-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2,3-epoxypropyl)-

RTECS #

XZ1994900

CAS #

2451-62-9

Updated

September 201

Molecular Weight

297.30

Molecular Formula

C12H15N3O6

Synonyms

1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(oxiranemethyl)- (9CI)
1,3,5-Triglycidyl isocyanurate
1,3,5-Triglycidylisocyanuric acid
1,3,5-Triglycidyl-s-triazinetrione
1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
Araldite PT 810
Glycidyl isocyanurate
N,N',N''-Triglycidyl isocyanurate
s-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2,3-epoxypropyl)- (8CI)
s-Triazine-2,4,6(1H,3H,5H)-trione, tris(2,3-epoxypropyl)-
TGT
Triglycidyl isocyanurate
Tris(2,3-epoxypropyl)isocyanurate
Tris(epoxypropyl)isocyanurate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeHPV413 -,-,2004

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse4 gm/kg/5D-continuousEPASR* 8EHQ-0491-0490
Cytogenetic Analysislung/hamster1200 µg/LMUREAV 241,175,1990
Cytogenetic Analysisintraperitoneal/mouse575 mg/kg/5D- intermittentHPV413 ,,2004
Cytogenetic Analysisoral/mouse213.5 mg/kg/5D- intermittentHPV413 ,,2004
DNA adductoral/mouse180 mg/kgHPV413 ,,2004
mutation in microorganisms/Salmonella typhimurium333 µg/plate (+enzymatic activation step)EMMUEG 19(Suppl 21),2,1992

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 2 gm/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTIS** OTS0555023

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 2000 mg/m3/4HBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
HPV413 -,-,2004
inhalation/rat lethal concentration (50 percent kill): >4160 mg/m3/4HLung, Thorax, or Respiration: DyspneaHPV413 -,-,2004
inhalation/rat lethal concentration (50 percent kill): 650 mg/m3/4HLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
HPV413 -,-,2004
oral/rat lethal dose (50 percent kill): 188 mg/kgLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
NTIS** OTS0555027
oral/rat lethal dose (50 percent kill): 222 mg/kgHPV413 -,-,2004
oral/rat lethal dose (50 percent kill): 138 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
HPV413 -,-,2004
skin/guinea pig lethal dose (50 percent kill): >200 mg/kgSkin: After topical application: Primary irritationHPV413 -,-,2004
skin/rabbit lethal dose (50 percent kill): >200 mg/kgSkin: After topical application: Primary irritationHPV413 -,-,2004
skin/rat lethal dose (50 percent kill): >3100 mg/kgSkin: After topical application: Primary irritationHPV413 -,-,2004
skin/rat lethal dose (50 percent kill): >2000 mg/kgHPV413 -,-,2004

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 40 mg/m3/5D- intermittentLung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV413 -,-,2004
oral/rat lowest published toxic dose: 5997.6 mg/kg/63W- intermittentBlood: Hemorrhage

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV413 -,-,2004

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg/m3DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.08 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 mg/m3, Carcinogen, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg/m3, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.08 mg/m3, JAN2002
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg/m3, OCT2007

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8890
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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