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Registry of Toxic Effects of Chemical Substances (RTECS)

s-Triazine-2,4,6-triol

RTECS #

XZ1800000

CAS #

108-80-5; 504-19-8

Updated

July 2010

Molecular Weight

129.09

Molecular Formula

C3H3N3O3

Synonyms

2,4,6-Trihydroxy-1,3,5-triazine
CP 4789
Cyanuric acid
Isocyanuric acid
Kyselina kyanurova (Czech)
Pseudocyanuric acid
s-2,4,6-Triazinetriol
s-Triazine-2,4,6(1H,3H,5H)-trione
sym-Triazinetriol
Tricyanic acid
Trihydroxycyanidine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild28ZPAK -,152,1972
eye /rabbit 20 mg/24H rinse mildMONS** -,-,1972

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 130 gm/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
VOONAW 16(1),82,1970
oral/rat lowest published toxic dose: 55 gm/kg/82W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
VOONAW 16(1),82,1970
oral/rat toxic dose: 60750 mg/kg/81W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
AJHEAA 64,155,1974
skin/mouse lowest published toxic dose: 2400 mg/kg/1W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
AJHEAA 64,155,1974
skin/mouse toxic dose: 138 gm/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
VOONAW 16(1),82,1970
subcutaneous/rat lowest published toxic dose: 27 gm/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease
VOONAW 16(1),82,1970
subcutaneous/rat toxic dose: 36 gm/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AJHEAA 64,155,1974

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/mouse lethal dose (50 percent kill): >500 mg/kgGISAAA 27(12),13,1962
intravenous/rat lethal dose (50 percent kill): >100 mg/kgGISAAA 27(12),13,1962
oral/mammal (species unspecified) lethal dose (50 percent kill): >5 gm/kgYKYUA6 31,959,1980
oral/mouse lethal dose (50 percent kill): 3400 mg/kgZKMAAX 25,345,1985
oral/rabbit Lethal dose: >10 gm/kgMONS** -,-,1972
oral/rat lethal dose (50 percent kill): >5000 mg/kgBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV379 -,-,2003
oral/rat lethal dose (50 percent kill): >5000 mg/kgBehavioral: Somnolence (general depressed activity)HPV409 -,-,2003
oral/rat lethal dose (50 percent kill): 7700 mg/kgZKMAAX 25,345,1985
skin/rabbit lethal dose (50 percent kill): >5000 mg/kgHPV409 -,-,2003
skin/rabbit lethal dose (50 percent kill): >5000 mg/kgBehavioral: Somnolence (general depressed activity)HPV379 -,-,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 5460 mg/kg/26W- intermittentKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 27(12),13,1962

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCRTOEC 19,491,2006

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,97,1998
Occupational Exposure Limit-POLANDMAC(time-weighted average) dust 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81788; Number of Industries 3; Total Number of Facilities 37; Number of Occupations 5; Total Number of Employees Exposed 2933; Total Number of Female Employees Exposed 1003
National Occupational Hazard Survey 1974Hazard Code 81788; Number of Industries 4; Total Number of Facilities 276; Number of Occupations 2; Total Number of Employees Exposed 10365

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9222
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Cyanuric acid, 5030
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