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s - Triazine, 2,4,6 - trichloro -

RTECS #: XZ1400000

CAS #: 108-77-0


UPDATE: May 2009 MW: 184.41 MF: C3Cl3N3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3,5 - Trichlorotriazine
  2. 2,4,6 - Trichlorotriazine
  3. 2,4,6 - Trichloro - s - triazine
  4. 2,4,6 - Trichloro - 1,3,5 - triazine
  5. Chlorotriazine
  6. Cyanurchloride
  7. Cyanuric acid chloride
  8. Cyanuric trichloride
  1. Cyanuryl chloride
  2. Kyanurchlorid (Czech)
  3. Trichlorocyanidine
  4. Trichloro - s - triazine
  5. Tricyanogen chloride
  6. s - Triazine trichloride
  7. sym - Trichlorotriazine
  8. syn - Trichlotriazin (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 g/24 hour severe 28ZPAK -,152,1972
skin
rabbit
500 mg/24 hour moderate 28ZPAK -,152,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
multiple
rat
lowest published toxic dose: 16 gm/kg/73 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
VOONAW 12(4),78,1966
oral
rat
lowest published toxic dose: 20 gm/kg/73 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors
VOONAW 12(4),78,1966


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 10 mg/m3/2 hour Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Musculoskeletal: Other changes
GTPZAB 12(8),35,1968
intraperitoneal
mouse
lethal dose (50 percent kill): 10 mg/kg N/R 38MKAJ 2C,4891,1982
intravenous
mouse
lethal dose (50 percent kill): 18 mg/kg N/R CSLNX* NX#07336
oral
mouse
lethal dose (50 percent kill): 350 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 12(8),35,1968
oral
rat
lethal dose (50 percent kill): 485 mg/kg Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease
GTPZAB 12(8),35,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,880 g/m3/4 hour/11 week- intermittent Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 12(8),35,1968
oral
rat
lowest published toxic dose: 2,800 mg/kg/28 day- continuous Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 12,119,1992
oral
rat
lowest published toxic dose: 100 mg/kg/5 day- intermittent Behavioral: Food intake (animal)

Gastrointestinal: Ulceration or bleeding from stomach

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0545266


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4559;
Number of Industries 2;
Total Number of Facilities 20;
Number of Occupations 3;
Total Number of Employees Exposed 2,336;
Total Number of Female Employees Exposed 299


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HTOPA*
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-

RTECS Compound Description:
   Tumorigen
   Primary Irritant

Click Here for Additional Information about RTECS

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