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Registry of Toxic Effects of Chemical Substances (RTECS)

s-Triazine, 2,4,6-trichloro-

RTECS #

XZ1400000

CAS #

108-77-0

Updated

April 2012

Molecular Weight

184.41

Molecular Formula

C3Cl3N3

Synonyms

1,3,5-Trichlorotriazine
2,4,6-Trichloro-1,3,5-triazine
2,4,6-Trichloro-s-triazine
2,4,6-Trichlorotriazine
Chlorotriazine
Cyanurchloride
Cyanuric acid chloride
Cyanuric trichloride
Cyanuryl chloride
Kyanurchlorid (Czech)
s-Triazine trichloride
sym-Trichlorotriazine
syn-Trichlotriazin (Czech)
Trichlorocyanidine
Trichloro-s-triazine
Tricyanogen chloride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 µg/24H severe28ZPAK -,152,1972
skin /rabbit 500 mg/24H moderate28ZPAK -,152,1972

Tumorigenic Data and References

Route/OrganismDoseEffectReference
multiple/rat lowest published toxic dose: 16 gm/kg/73W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
VOONAW 12(4),78,1966
oral/rat lowest published toxic dose: 20 gm/kg/73W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors
VOONAW 12(4),78,1966

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 10 mg/m3/2HAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Musculoskeletal: Other changes
GTPZAB 12(8),35,1968
intraperitoneal/mouse lethal dose (50 percent kill): 10 mg/kg38MKAJ 2C,4891,1982
intravenous/mouse lethal dose (50 percent kill): 18 mg/kgCSLNX* NX#07336
oral/mouse lethal dose (50 percent kill): 350 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 12(8),35,1968
oral/rat lethal dose (50 percent kill): 485 mg/kgBehavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease
GTPZAB 12(8),35,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1880 µg/m3/4H/11W- intermittentBlood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 12(8),35,1968
oral/rat lowest published toxic dose: 2800 mg/kg/28D- continuousLiver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 12,119,1992
oral/rat lowest published toxic dose: 100 mg/kg/5D- intermittentBehavioral: Food intake (animal)

Gastrointestinal: Ulceration or bleeding from stomach

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0545266

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHTOPA* 1,501,2002

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg/m3, NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4559; Number of Industries 2; Total Number of Facilities 20; Number of Occupations 3; Total Number of Employees Exposed 2336; Total Number of Female Employees Exposed 299

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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