s-Triazine, 2-chloro-4-ethylamino-6-isopropylamino-

RTECS #

XY5600000

CAS #

1912-24-9; 11121-31-6; 12040-45-8; 12797-72-7; 39400-72-1; 69771-31-9; 93616-39-8
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

215.72

Molecular Formula

C₈H₁₄ClN₅

Synonyms

1,3,5-Triazine-2,4-diamine, 6-chloro-N-ethyl-N'-(1-methylethyl)- (9CI)
1-Chloro-3-ethylamino-5-isopropylamino-2,4,6-triazine
1-Chloro-3-ethylamino-5-isopropylamino-s-triazine
2-Aethylamino-4-chlor-6-isopropylamino-1,3,5-triazin (German)
2-Aethylamino-4-isopropylamino-6-chlor-1,3,5-triazin (German)
2-Chloro-4-(2-propylamino)-6-ethylamino-s-triazine
2-Chloro-4-ethylamineisopropylamine-s-triazine
2-Chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine
2-Chloro-4-ethylamino-6-isopropylamino-s-triazine
6-Chloro-N-ethyl-N'-(1-methylethyl)-1,3,5-triazine-2,4-diamine
6-Chloro-N-ethyl-N9-(1-methylethyl)-1,3,5-triazine-2,4-diamine
A 361
Aatram 20G
Aatrex
Aatrex 4L
Aatrex 80W
Aatrex nine-O
Aktikon
Aktikon PK
Aktinit A
Aktinit PK
Aneldazin
Argezin
Atrataf
Atrazin
Atrazine
Atrazine (ACGIH)
Azoprim
Ceasin 50
Cekuzina-T
Chromozin
Cyazin
G 30027
Geigy 30,027
Gesaprim
Herbatoxol
Hungazin
Hungazin PK
Oleogesaprim
Primatol A
Radazin
Technical atrazine
Technical grade atrazine
Triazine A 1294
Vectal
Vectal SC
Weedex A
Wonuk
Zeapos
Zeazin
Zeazine
Zeopos

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /mammal (species unspecified)	100 mg	severe	VRDEA5 (5),133,1977
eye /rabbit	6320 µg	severe	CIGET* -,-,1977
skin /mammal (species unspecified)	500 mg	mild	VRDEA5 (5),133,1977
skin /rabbit	38 mg open irritation test	mild	CIGET* -,-,1977

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lymphocyte/human	1 mg/L	MUREAV 281,295,1992
Cytogenetic Analysis	oral/mouse	72 mg/kg/30D-continuous	EMMUEG 19,77,1992
Cytogenetic Analysis	oral/hamster	5.0 µmol/L	MUREAV 608,28,2006
DNA Damage	intraperitoneal/mouse	500 mg/kg	MUREAV 493,1,2001
DNA Damage	oral/rat	2100 mg/kg/7D	MUREAV 654,145,2008
DNA Damage	multiple/other fish	6.25 µg/L/72H-continuous	PCBPBS 90,42,2008
DNA Damage	multiple/other fish	5 µg/L/2D- intermittent	FCTOD7 49,1431,2011
DNA Damage	oral/rat	875 mg/kg	MUREAV 209,145,1988
DNA Damage	lymphocyte/human	100 mg/L	MUREAV 344,41,1995
Dominant Lethal Test	parenteral/Drosophila melanogaster	556 µmol/L	JTEHD6 3,691,1977
Dominant Lethal Test	oral/Drosophila melanogaster	100 ppm	JTEHD6 3,691,1977
Dominant Lethal Test	oral/mouse	1500 mg/kg	MUREAV 74,77,1980
gene conversion and mitotic recombination	/Aspergillus nidulans	6 mmol/L	MUREAV 74,77,1980
host-mediated assay	Escherichia coli/mouse	100 mg/kg	MUREAV 74,77,1980
host-mediated assay	Escherichia coli/rat	100 mg/kg	CECED9 6388,328,1980
micronucleus test	multiple/other fish	5 µg/L/2D- intermittent	FCTOD7 49,1431,2011
micronucleus test	oral/rat	2100 mg/kg/7D	MUREAV 654,145,2008
micronucleus test	oral/rat	2100 mg/kg	MUREAV 654,145,2008
micronucleus test	multiple/other fish	6.25 µg/L/72H-continuous	PCBPBS 90,42,2008
mutation in microorganisms	/Aspergillus nidulans	6 mmol/L (+enzymatic activation step)	MUREAV 74,77,1980
mutation in microorganisms	lung/hamster	3 mmol/L (+enzymatic activation step)	MUREAV 74,77,1980
mutation in microorganisms	/Schizosaccharomyces pombe	6 mmol/L (+enzymatic activation step)	MUREAV 74,77,1980
other mutation test systems	oral/mouse	216 mg/kg/90D-continuous	EMMUEG 19,77,1992
sex chromosome loss and nondisjunction	/Neurospora crassa	10 mg/L	MUREAV 167,35,1986
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	100 ppm	JTEHD6 3,691,1977
specific locus test	oral/Drosophila melanogaster	5 mmol/L	MUREAV 280,291,1992
sperm morphology	sperm/human	100 µmol/L/1H	REPTED 22,508,2006
Unscheduled DNA Synthesis	fibroblast/human	3 mmol/L	MUREAV 74,77,1980

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	1028 mg/kg (60D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	JJATDK 20,61,2000
oral/rat	1000 mg/kg (6-10D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	REPTED 15,61,2000
oral/rat	1000 mg/kg (11-15D pregnant)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	REPTED 15,61,2000
oral/rat	500 mg/kg (6-10D pregnant)	Reproductive: Maternal effects: Parturition Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death	REPTED 15,61,2000
oral/rat	600 mg/kg (8-10D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	REPTED 15,61,2000
oral/rat	1000 mg/kg (6-10D pregnant)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	REPTED 15,61,2000
oral/rat	35 mg/kg (10D preg-23D after birth)	Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system	TOXID9 72,120,2003
oral/rat	200 mg/kg (6-10D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	TOXID9 72,77,2003
oral/rat	1260 mg/kg (10-22D preg/23D after birth)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic	TOSCF2 76,366,2003
oral/rat	500 mg/kg (15-19D pregnant)	Reproductive: Specific developmental abnormalities: Skin and skin appendages Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Delayed effects	TXAPA9 195,23,2004
oral/rat	300 mg/kg (17-19D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TOXID9 44,230,2005
oral/rat	700 mg/kg (13-19D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TOXID9 44,230,2005
oral/rat	7 gm/kg (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	JTEHD6 24,307,1988
oral/rat	700 mg/kg (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Musculoskeletal system	JTEHD6 24,307,1988
oral/rat	720 mg/kg (10D prior to copulation)	Reproductive: Other effects on female Reproductive: Effects on newborn: Behavioral	APHHDU 83,79,1995
oral/rat	300 mg/kg (15-17D pregnant)	Reproductive: Specific developmental abnormalities: Skin and skin appendages	TOXID9 78,218,2004
oral/rat	300 mg/kg (17-19D pregnant)	Reproductive: Specific developmental abnormalities: Skin and skin appendages Reproductive: Effects on newborn: Delayed effects	TOXID9 78,218,2004
oral/rat	700 mg/kg (13-19D pregnant)	Reproductive: Specific developmental abnormalities: Skin and skin appendages Reproductive: Effects on newborn: Delayed effects	TOXID9 78,218,2004
oral/rat	500 mg/kg (15-19D pregnant)	Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TOXID9 66,371,2002
oral/rat	500 mg/kg (15-19D pregnant)	Reproductive: Specific developmental abnormalities: Urogenital system	TOXID9 66,373,2002
oral/rat	500 mg/kg (15-19D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Physical	TXAPA9 218,238,2007
oral/rat	500 mg/kg (15-19D pregnant)	Reproductive: Effects on newborn: Delayed effects	TXAPA9 218,238,2007
oral/mouse	2900 µg/kg (14-21D preg/21D after birth)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Other developmental abnormalities	TXCYAC 279,19,2011
oral/mouse	29 µg/kg (14-21D preg/21D after birth)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Other developmental abnormalities	TXCYAC 279,19,2011
oral/mouse	123 µg/kg (multigeneration)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Biochemical and metabolic	TXCYAC 308,74,2013
oral/mouse	123 µg/kg (multigeneration)	Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)	TXCYAC 308,74,2013
oral/mouse	620 µg/kg (1-20D pregnant)	Reproductive: Effects on newborn: Other neonatal measures or effects Reproductive: Effects on newborn: Biochemical and metabolic	TOXRE* 1,53,2014
oral/mouse	620 µg/kg (1-20D after birth)	Reproductive: Effects on newborn: Other neonatal measures or effects Reproductive: Effects on newborn: Biochemical and metabolic	TOXRE* 1,53,2014
oral/rabbit	975 mg/kg (7-19D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death	JTEHD6 24,307,1988
oral/rabbit	975 mg/kg (7-19D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	JTEHD6 24,307,1988
oral/rat	125 mg/kg (5D after birth)	Reproductive: Specific developmental abnormalities: Urogenital system	TOSCF2 52,68,1999
oral/mouse	29 mg/kg (14-21D preg/1-21D after birth)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Behavioral	REPTED 22,263,2006
subcutaneous/mouse	616000 µg/kg (10D preg-10D after birth)	Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects	TXAPA9 214,69,2006
subcutaneous/rat	2400 mg/kg (3-9D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	BECTA6 9,301,1973
subcutaneous/rat	6 gm/kg (3-9D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	BECTA6 9,301,1973
subcutaneous/mouse	418 mg/kg (6-14D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death	NTIS** PB223-160
subcutaneous/mouse	588 mg/kg (10-21D preg/9D after birth)	Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system Reproductive: Effects on newborn: Delayed effects	TOXID9 78,10,2004
unreported route/rat	125 mg/kg (5D after birth)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Biochemical and metabolic	TOXID9 78,116,2004
unreported route/rat	500 mg/kg (15-19D pregnant)	Reproductive: Effects on newborn: Other neonatal measures or effects	TOXID9 60,391,2001
unreported route/rat	875 mg/kg (14-20D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TOXID9 90,190,2006

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 9000 mg/kg/78W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	NTIS** PB223-159
oral/rat	lowest published toxic dose: 36.5 gm/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Reproductive: Other reproductive system tumors	HBPTO* 2,1514,2001
oral/rat	lowest published toxic dose: 33775 mg/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Blood: Leukemia Reproductive: Tumorigenic effects: Uterine tumors	NEOLA4 37,533,1990

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, embryonic cells	Inhibitor Concentration Low: 1 mmol/L/24H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 27,995,2013
In Vitro/Human, embryonic cells	Inhibitor Concentration Low: 10 pmol/L/24H	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,995,2013
In Vitro/Human, endocrine tumor	Inhibitor Concentration Low: 5 µmol/L/24H	In Vitro Toxicity Studies: Other assays	TIVIEQ 26,107,2012
In Vitro/Human, endocrine tumor	Inhibitor Concentration (50 percent kill): 3.3 µmol/L/24H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TXAPA9 268,309,2013
In Vitro/Human, liver tumor	Inhibitor Concentration Low: 50 µmol/L/48H	In Vitro Toxicity Studies: Other assays	TIVIEQ 28,156,2014
In Vitro/jvx	Inhibitor Concentration Low: 50 µmol/L/24H	In Vitro Toxicity Studies: Other assays	TIVIEQ 26,107,2012
In Vitro/Mouse, liver	Inhibitor Concentration Low: 10 µmol/L/48H	In Vitro Toxicity Studies: Other assays	TIVIEQ 26,718,2012
In Vitro/mpd	Inhibitor Concentration (50 percent kill): 672.8 µmol/L/4H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 76,61,2015
In Vitro/mpd	Inhibitor Concentration (50 percent kill): 457.1 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 76,61,2015
In Vitro/mpd	Inhibitor Concentration (50 percent kill): 1 µmol/L/24H	Immunological Including Allergic: Decrease in cellular immune response In Vitro Toxicity Studies: Apoptosis in vitro	FCTOD7 76,61,2015
In Vitro/nta	Inhibitor Concentration Low: 0.03 µg/L	In Vitro Toxicity Studies: Other assays	FCTOD7 98,25,2016
In Vitro/nta	Inhibitor Concentration Low: 3 µg/L/72H	In Vitro Toxicity Studies: Other assays Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	FCTOD7 109,727,2017
In Vitro/ntd	Inhibitor Concentration Low: 50 µg/L	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. Reproductive: Maternal effects: Oogenesis	TIVIEQ 32,63,2016
In Vitro/Rat, endocrine tumor	Inhibitor Concentration (50 percent kill): 5 µmol/L/6H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	TXAPA9 265,19,2012
In Vitro/Rat, endocrine tumor	Inhibitor Concentration Low: 10 µmol/L	Endocrine: Other changes	TXAPA9 265,19,2012
In Vitro/Rat, testis	Inhibitor Concentration Low: 10 µmol/L/2H	Endocrine: Androgenic Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	TXAPA9 265,19,2012
In Vitro/Rat, testis	Inhibitor Concentration Low: 10 µmol/L/24H	In Vitro Toxicity Studies: Other assays	TIVIEQ 26,107,2012
In Vitro/Rat, testis	Inhibitor Concentration Low: 232 µmol/L/6H	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,700,2013
In Vitro/Rat, testis	Inhibitor Concentration Low: 25 mg/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 25,1588,2011
In Vitro/Rat, testis	Inhibitor Concentration Low: 50 mg/L/72H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 25,1588,2011
inhalation/rat	lethal concentration (50 percent kill): 700 mg/kg		ENTOX* -,188,2005
inhalation/rat	lethal concentration (50 percent kill): 5200 mg/m³/4H		FMCHA2 -,C29,1991
intraperitoneal/mouse	lethal dose (50 percent kill): 626 mg/kg		PESTD5 17,351,1976
intraperitoneal/mouse	lowest published toxic dose: 100 mg/kg	Endocrine: Other changes Blood: Changes in spleen Immunological Including Allergic: Decrease in cellular immune response	TOXID9 72,172,2003
intraperitoneal/mouse	lowest published toxic dose: 100 mg/kg	Immunological Including Allergic: Decrease in humoral immune response	TOXID9 60,24,2001
intraperitoneal/rat	lowest published toxic dose: 100 mg/kg	Cardiac: Arrythmias (indlucing changes in conduction)	TOXID9 90,304,2006
intraperitoneal/rat	lowest published toxic dose: 300 mg/kg	Liver: Other changes	ETOPFR 12,1,2002
intraperitoneal/rat	lowest published toxic dose: 100 mg/kg	Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	TOXID9 44,400,2005
intraperitoneal/rat	lethal dose (50 percent kill): 235 mg/kg		PESTD5 17,351,1976
intraperitoneal/rat	lowest published toxic dose: 100 mg/kg/90M	Behavioral: Change in motor activity (specific assay)	NRTXDN 58,161,2017
oral/hamster	lethal dose (50 percent kill): 1 gm/kg		TXAPA9 48,A192,1979
oral/mouse	lethal dose (50 percent kill): 850 mg/kg		85GMAT -,36,1982
oral/mouse	lowest published toxic dose: 875 mg/kg	Endocrine: Changes in thymus weight Blood: Changes in spleen	TOXID9 72(Suppl 1),329,2003
oral/mouse	lowest published toxic dose: 8.75 mg/kg	Immunological Including Allergic: Decrease in cellular immune response	TOXID9 72(Suppl 1),329,2003
oral/rabbit	lethal dose (50 percent kill): 750 mg/kg		ENTOX* -,188,2005
oral/rat	lowest published toxic dose: 75 mg/kg	Endocrine: Adrenal cortex hyperplasia Endocrine: Other changes	TOXID9 -,18,2008
oral/rat	lowest published toxic dose: 75 mg/kg	Endocrine: Change in LH Endocrine: Other changes	TOXID9 -,30,2009
oral/rat	lethal dose (50 percent kill): 2 gm/kg	Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Body temperature decrease	ENTOX* -,188,2005
oral/rat	lowest published toxic dose: 300 mg/kg	Liver: Tumors Tumorigenic: Facilitates action of known carcinogens	TOSCF2 53,297,2000
oral/rat	lowest published toxic dose: 40 mg/kg	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOXID9 72,77,2003
oral/rat	lethal dose (50 percent kill): 672 mg/kg		FAATDF 7,299,1986
oral/rat	lowest published toxic dose: 200 mg/kg	Endocrine: Androgenic Endocrine: Estrogenic Biochemical: Metabolism (intermediary): Other	TOXID9 78,117,2004
oral/rat	lowest published toxic dose: 5 mg/kg	Endocrine: Other changes	NETEEC 34,295,2012
oral/rat	lowest published toxic dose: 200 mg/kg	Taste: Change in function	NETEEC 34,295,2012
oral/rat	lowest published toxic dose: 50 mg/kg	Behavioral: Food intake (animal)	NETEEC 34,295,2012
skin/rabbit	lethal dose (50 percent kill): 7500 mg/kg		28ZEAL 5,15,1976
skin/rat	lethal dose (50 percent kill): >12500 mg/kg		GISAAA 55(7),87,1990
skin/rat	lethal dose (50 percent kill): 3 gm/kg	Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Body temperature decrease	ENTOX* -,188,2005
Tank with water/Carp	lowest published toxic concentration: 4.28 µg/L/40 D	Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	FCTOD7 62,148,2013
Tank with water/Carp	lowest published toxic concentration: 42.8 µg/L/40 D	Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	FCTOD7 62,148,2013
Tank with water/other fish	lowest published toxic concentration: 0.17 mg/L/21D	Liver: Other changes	TIVIEQ 31,217,1995
Tank with water/Zebrafish	lowest published toxic concentration: 3 µg/L/28 D	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	FCTOD7 61,82,2013
Tank with water/Zebrafish	lowest published toxic concentration: 90 µg/L/28 D	Aquatic organism effects: Growth retardation Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	FCTOD7 61,82,2013
Tank with water/Zebrafish	lowest published toxic concentration: 1000 µg/L/14D	Behavioral: Change in psychophysiological tests Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NETEEC 44,62,2014
Tank with water/Zebrafish	lowest published toxic concentration: 3 µg/L/3D	Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Delayed effects	TXCYAC 333,156,2015
Tank with water/Zebrafish	toxic concentration: 0.3 mg/L/24H	Biochemical: Metabolism (intermediary): Lipids including transport	TOXIA6 4,240,2017
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 1400 mg/kg		GISAAA 44(6),81,1979

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 10 mg/m³/26W- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	KHZDAN 12,114,1969
intraperitoneal/rat	lowest published toxic dose: 360 mg/kg/23D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JAPTO* 20,61,2000
intraperitoneal/rat	lowest published toxic dose: 1020 mg/kg/60D- intermittent	Endocrine: Changes in pituitary weight Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Related to Chronic Data: Changes in prostate weight	JAPTO* 20,61,2000
intraperitoneal/rat	lowest published toxic dose: 2040 mg/kg/60D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct	JAPTO* 20,61,2000
intraperitoneal/rat	lowest published toxic dose: 30 mg/kg/3D- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	ETOPFR 12,1,2002
intraperitoneal/rat	lowest published toxic dose: 600 mg/kg/2W- intermittent	Behavioral: Change in motor activity (specific assay) Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	NRTXDN 34,82,2013
oral/Dog	lowest published toxic dose: 9100 mg/kg/52W- intermittent	Cardiac: Other changes	HBPTO* 2,1512,2001
oral/Dog	lowest published toxic dose: 9125 mg/kg/1Y- continuous	Cardiac: Changes in coronary arteries Cardiac: Pulse rate increased without fall in BP Cardiac: Other changes	NTIS** OTS0543210
oral/mouse	lowest published toxic dose: 2100 mg/kg/21D- intermittent	Liver: Changes in liver weight	AECTCV 24,449,1993
oral/mouse	lowest published toxic dose: 20.8 gm/kg/78W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HBPTO* 2,1514,2001
oral/mouse	lowest published toxic dose: 350 mg/kg/14D- intermittent	Endocrine: Changes in spleen weight	TXCYAC 209,15,2005
oral/mouse	lowest published toxic dose: 3500 mg/kg/14D- intermittent	Endocrine: Changes in spleen weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXCYAC 209,15,2005
oral/mouse	lowest published toxic dose: 7000 mg/kg/14D- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in spleen weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXCYAC 209,15,2005
oral/mouse	lowest published toxic dose: 1750 mg/kg/14D- intermittent	Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	TOXID9 44,400,2005
oral/mouse	lowest published toxic dose: 14000 µg/kg/20W- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport	TOLED5 225,392,2014
oral/mouse	lowest published toxic dose: 1125 mg/kg/9D- intermittent	Behavioral: Change in psychophysiological tests	NETEEC 39,26,2013
oral/mouse	lowest published toxic dose: 500 mg/kg/4D- intermittent	Behavioral: Change in motor activity (specific assay)	NETEEC 39,26,2013
oral/mouse	lowest published toxic dose: 1250 mg/kg/10D- intermittent	Behavioral: Change in psychophysiological tests Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	NETEEC 39,26,2013
oral/mouse	lowest published toxic dose: 50 mg/kg/10D- intermittent	Biochemical: Metabolism (intermediary): Other	TXCYAC 326,130,2014
oral/mouse	lowest published toxic dose: 620 µg/kg/20D- continuous	Cardiac: Changes in heart weight Liver: Other changes Liver: Changes in liver weight	TOXRE* 1,53,2014
oral/mouse	lowest published toxic dose: 620 µg/kg/20D- continuous	Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Reproductive: Maternal effects: Ovaries, fallopian tubes	TOXRE* 1,53,2014
oral/mouse	lowest published toxic dose: 620 µg/kg/20D- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Metabolism (intermediary): Lipids including transport	TOXRE* 1,53,2014
oral/mouse	lowest published toxic dose: 620 µg/kg/20D- continuous	Biochemical: Metabolism (intermediary): Other	TOXRE* 1,53,2014
oral/mouse	lowest published toxic dose: 109.2 mg/kg/26W- intermittent	Biochemical: Metabolism (intermediary): Other Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	TOXID9 90,304,2006
oral/mouse	lowest published toxic dose: 7000 mg/kg/14D- intermittent	Blood: Changes in erythrocyte (RBC) count Immunological Including Allergic: Increase in cellular immune response Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTPTR* IMM-94003
oral/mouse	lowest published toxic dose: 3500 mg/kg/14D- intermittent	Behavioral: Alteration of classical conditioning Endocrine: Changes in spleen weight Endocrine: Changes in thymus weight	NTPTR* IMM-94003
oral/mouse	lowest published toxic dose: 3500 mg/kg/14D- intermittent	Blood: Changes in spleen	NTPTR* IMM-94003
oral/mouse	lowest published toxic dose: 4000 mg/kg/8D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTPTR* IMM-94002
oral/mouse	lowest published toxic dose: 7500 mg/kg/15D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in thymus weight	NTPTR* IMM-94002
oral/mouse	lowest published toxic dose: 7500 mg/kg/15D- intermittent	Blood: Normocytic anemia Blood: Changes in erythrocyte (RBC) count Immunological Including Allergic: Decrease in cellular immune response	NTPTR* IMM-94002
oral/mouse	lowest published toxic dose: 7500 mg/kg/15D- intermittent	Immunological Including Allergic: Increase in humoral response	NTPTR* IMM-94002
oral/mouse	lowest published toxic dose: 375 mg/kg/15D- intermittent	Blood: Changes in other cell count (unspecified)	NTPTR* IMM-94002
oral/pig	lowest published toxic dose: 20 mg/kg/20D- continuous	Endocrine: Change in LH Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TXAPA9 197,351,2004
oral/pig	lowest published toxic dose: 38 mg/kg/19D- intermittent	Endocrine: Change in LH Endocrine: Effect on menstrual cycle	TOLED5 85,9,1996
oral/rat	lowest published toxic dose: 3825 mg/kg/21D- intermittent	Reproductive: Maternal effects: Menstrual cycle changes or disorders	REPTED 10,257,1996
oral/rat	lowest published toxic dose: 250 mg/kg/5D- intermittent	Endocrine: Other changes	TOSCF2 52,68,1999
oral/rat	lowest published toxic dose: 145600 mg/kg/104W- continuous	Endocrine: Tumors Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)	HBPTO* 1,738,2001
oral/rat	lowest published toxic dose: 98 mg/kg/4W- continuous	Endocrine: Effect on menstrual cycle	JTEHD6 43,169,1994
oral/rat	lowest published toxic dose: 7280 mg/kg/52W- continuous	Skin and Appendages: Other: Breast	JTEHD6 43,169,1994
oral/rat	lowest published toxic dose: 4200 mg/kg/14D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JTEHD6 43,155,1994
oral/rat	lowest published toxic dose: 1400 mg/kg/14D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in ovarian weight Related to Chronic Data: Changes in uterine weight	JTEHD6 43,155,1994
oral/rat	lowest published toxic dose: 1400 mg/kg/14D- intermittent	Endocrine: Estrogenic Endocrine: Effect on menstrual cycle Blood: Other changes	JTEHD6 43,155,1994
oral/rat	lowest published toxic dose: 4200 mg/kg/14D- intermittent	Endocrine: Other changes Blood: Other changes Reproductive: Maternal effects: Uterus, cervix, vagina	JTEHD6 43,155,1994
oral/rat	lowest published toxic dose: 600 mg/kg/2D- intermittent	Reproductive: Maternal effects: Uterus, cervix, vagina Tumorigenic: Cells (cultured) transformed	JTEHF8 43,183,1994
oral/rat	lowest published toxic dose: 2970 mg/kg/90D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HBPTO* 2,1512,2001
oral/rat	lowest published toxic dose: 6 gm/kg/30D- intermittent	Endocrine: Other changes Related to Chronic Data: Changes in prostate weight	TOXID9 54,366,2000
oral/rat	lowest published toxic dose: 33572 mg/kg/22W- intermittent	Liver: Other changes Blood: Pigmented or nucleated red blood cells Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	KHZDAN 12,114,1969
oral/rat	lowest published toxic dose: 2800 mg/kg/14D- intermittent	Kidney, Ureter, and Bladder: Proteinuria Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Other changes	BECTA6 36,325,1986
oral/rat	lowest published toxic dose: 4200 mg/kg/7D- intermittent	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	JJATDK 7,373,1987
oral/rat	lowest published toxic dose: 125 mg/kg/5D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	REPTED 15,61,2000
oral/rat	lowest published toxic dose: 600 mg/kg/3D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	REPTED 15,61,2000
oral/rat	lowest published toxic dose: 3150 mg/kg/21D- intermittent	Endocrine: Change in LH Endocrine: Other changes	TOSCF2 53,297,2000
oral/rat	lowest published toxic dose: 1575 mg/kg/21D- intermittent	Endocrine: Change in LH	TOSCF2 53,297,2000
oral/rat	lowest published toxic dose: 900 mg/kg/3D- intermittent	Reproductive: Maternal effects: Oogenesis	TOSCF2 53,297,2000
oral/rat	lowest published toxic dose: 400 mg/kg/8D- intermittent	Reproductive: Maternal effects: Ovaries, fallopian tubes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOSCF2 58,135,2000
oral/rat	lowest published toxic dose: 800 mg/kg/8D- intermittent	Endocrine: Change in LH Endocrine: Other changes Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	TOSCF2 58,135,2000
oral/rat	lowest published toxic dose: 800 mg/kg/8D- intermittent	Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOSCF2 58,135,2000
oral/rat	lowest published toxic dose: 1600 mg/kg/8D- intermittent	Endocrine: Estrogenic	TOSCF2 58,135,2000
oral/rat	lowest published toxic dose: 800 mg/kg/4D- intermittent	Endocrine: Estrogenic Endocrine: Differential effect of sex or castration on observed toxicity Biochemical: Metabolism (intermediary): Other	TOXID9 78,117,2004
oral/rat	lowest published toxic dose: 4200 mg/kg/21D- intermittent	Endocrine: Estrogenic Endocrine: Differential effect of sex or castration on observed toxicity Biochemical: Metabolism (intermediary): Other	TOXID9 78,117,2004
oral/rat	lowest published toxic dose: 18.75 mg/kg/3D- intermittent	Endocrine: Change in LH	TOXID9 44,353,2005
oral/rat	lowest published toxic dose: 225 mg/kg/3D- intermittent	Endocrine: Other changes	TOXID9 44,353,2005
oral/rat	lowest published toxic dose: 910 mg/kg/0.5Y- continuous	Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites	TOXID9 78,277,2004
oral/rat	lowest published toxic dose: 1820 mg/kg/0.5Y- continuous	Behavioral: Change in motor activity (specific assay) Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	TOXID9 78,277,2004
oral/rat	lowest published toxic dose: 300 mg/kg/3D- intermittent	Behavioral: Alteration of classical conditioning	TOXID9 44,230,2005
oral/rat	lowest published toxic dose: 900 mg/kg/9D- intermittent	Reproductive: Maternal effects: Uterus, cervix, vagina Related to Chronic Data: Changes in uterine weight	RTOPDW 35,468,2002
oral/rat	lowest published toxic dose: 750 mg/kg/25D- intermittent	Reproductive: Maternal effects: Uterus, cervix, vagina	RTOPDW 35,468,2002
oral/rat	lowest published toxic dose: 800 mg/kg/10D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXCYAC 195,177,2004
oral/rat	lowest published toxic dose: 14.6 gm/kg/2Y- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HBPTO* 2,1514,2001
oral/rat	lowest published toxic dose: 150 mg/kg/3D- intermittent	Endocrine: Androgenic	REPTED 16,275,2002
oral/rat	lowest published toxic dose: 1350 mg/kg/27D- intermittent	Endocrine: Androgenic	REPTED 16,275,2002
oral/rat	lowest published toxic dose: 420 mg/kg/7D- intermittent	Endocrine: Androgenic	JSTBBK 33,141,1989
oral/rat	lowest published toxic dose: 300 mg/kg/3D- intermittent	Blood: Changes in leukocyte (WBC) count	HBPTO* 1,777,2001
oral/rat	lowest published toxic dose: 1440 mg/kg/6D- intermittent	Endocrine: Evidence of thyroid hypofunction	BESCE5 9,60,1996
oral/rat	lowest published toxic dose: 318.5 mg/kg/13W- continuous	Endocrine: Estrogenic	JTEHD6 43,169,1994
oral/rat	lowest published toxic dose: 5460 mg/kg/39W- continuous	Endocrine: Other changes	JTEHD6 43,169,1994
oral/rat	lowest published toxic dose: 910 mg/kg/13W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTEHD6 43,169,1994
oral/rat	lowest published toxic dose: 14700 mg/kg/105W- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JTEHD6 43,169,1994
oral/rat	lowest published toxic dose: 105 mg/kg/30D- continuous	Endocrine: Effect on menstrual cycle	JTEHD6 43,169,1994
oral/rat	lowest published toxic dose: 315 mg/kg/90D- continuous	Endocrine: Estrogenic	JTEHD6 43,169,1994
oral/rat	lowest published toxic dose: 800 mg/kg/40W- continuous	Endocrine: Change in gonadotropins	JTEHD6 43,169,1994
oral/rat	lowest published toxic dose: 14700 mg/kg/105W- continuous	Endocrine: Tumors	JTEHD6 43,169,1994
oral/rat	lowest published toxic dose: 7280 mg/kg/52W- continuous	Endocrine: Tumors	JTEHD6 43,169,1994
oral/rat	lowest published toxic dose: 1500 mg/kg/5D- intermittent	Endocrine: Change in LH	TOXID9 72,133,2003
oral/rat	lowest published toxic dose: 1572.2 mg/kg/2W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 41,1811,2003
oral/rat	lowest published toxic dose: 18.87 gm/kg/24W- continuous	Behavioral: Food intake (animal) Brain and Coverings: Changes in brain weight Related to Chronic Data: Changes in testicular weight	FCTOD7 41,1811,2003
oral/rat	lowest published toxic dose: 50 mg/kg/4D- intermittent	Endocrine: Adrenal cortex hyperplasia	TOXID9 -,18,2008
oral/rat	lowest published toxic dose: 300 mg/kg/4D- intermittent	Endocrine: Adrenal cortex hyperplasia Endocrine: Other changes	TOXID9 -,18,2008
oral/rat	lowest published toxic dose: 400 mg/kg/4D- intermittent	Endocrine: Change in LH Endocrine: Change in gonadotropins Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOXID9 -,271,2008
oral/rat	lowest published toxic dose: 800 mg/kg/4D- intermittent	Endocrine: Other changes Biochemical: Metabolism (intermediary): Other proteins	TOXID9 12,471,2008
oral/rat	lowest published toxic dose: 150 mg/kg/3D- intermittent	Endocrine: Estrogenic Endocrine: Other changes	TOXID9 -,121,2009
oral/rat	lowest published toxic dose: 420 mg/kg/2W- intermittent	Eye: Lacrimation	JTSCDR 34,SP147,2009
oral/rat	lowest published toxic dose: 4200 mg/kg/2W- intermittent	Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Maternal effects: Menstrual cycle changes or disorders Related to Chronic Data: Changes in ovarian weight	JTSCDR 34,SP147,2009
oral/rat	lowest published toxic dose: 840 mg/kg/4W- intermittent	Eye: Lacrimation Gastrointestinal: Changes in structure or function of salivary glands Reproductive: Maternal effects: Menstrual cycle changes or disorders	JTSCDR 34,SP147,2009
oral/rat	lowest published toxic dose: 8400 mg/kg/4W- intermittent	Reproductive: Maternal effects: Menstrual cycle changes or disorders Related to Chronic Data: Changes in ovarian weight Related to Chronic Data: Changes in uterine weight	JTSCDR 34,SP147,2009
oral/rat	lowest published toxic dose: 2440 mg/kg/244D- continuous	Behavioral: Change in motor activity (specific assay)	NETEEC 33,263,2011
oral/rat	lowest published toxic dose: 3350 mg/kg/335D- continuous	Behavioral: Alteration of classical conditioning	NETEEC 33,263,2011
oral/rat	lowest published toxic dose: 3650 mg/kg/1Y- continuous	Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	NETEEC 33,263,2011
oral/rat	lowest published toxic dose: 3640 mg/kg/0.5Y- continuous	Endocrine: Change in LH	TOXID9 60,321,2001
oral/rat	lowest published toxic dose: 1800 mg/kg/180D- intermittent	Behavioral: Change in motor activity (specific assay)	TXAPA9 289,185,2015
oral/rat	lowest published toxic dose: 150 mg/kg/3D- intermittent	Endocrine: Other changes Reproductive: Maternal effects: Uterus, cervix, vagina Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	HBPTO* 1,738,2001
oral/rat	lowest published toxic dose: 3650 mg/kg/365D- continuous	Behavioral: Change in motor activity (specific assay) Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	NETEEC 40,59,2013
skin/rabbit	lowest published toxic dose: 25 gm/kg/25D- continuous	Blood: Other changes Skin: After systemic exposure: Dermatitis, other	NTIS** OTS0555001
subcutaneous/rat	lowest published toxic dose: 45 mg/kg/3W- intermittent	Gastrointestinal: Other changes Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Other	LIFSAK 69,901,2001
unreported route/rat	lowest published toxic dose: 840 mg/kg/7D- continuous	Endocrine: Effect on menstrual cycle	HBPTO* 1,738,2001
unreported route/rat	lowest published toxic dose: 1500 mg/kg/5D- intermittent	Endocrine: Change in LH Endocrine: Estrogenic	TOXID9 66,339,2002
unreported route/rat	lowest published toxic dose: 1575 mg/kg/21D- continuous	Endocrine: Estrogenic Endocrine: Other changes Reproductive: Maternal effects: Menstrual cycle changes or disorders	HBPTO* 1,738,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 53,441,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 73,59,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 53,441,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 73,59,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 73,59,1999
TOXICOLOGY REVIEW		CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		MUREAV 613,17,2006
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		ENTOX* -,188,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		BCLPT* 96,131,2005
TOXICOLOGY REVIEW		MUREAV 658,124,2008
TOXICOLOGY REVIEW		JTEHD6 7,1,2004
TOXICOLOGY REVIEW		REPTED 23,337,2007
TOXICOLOGY REVIEW		MUREAV 544,305,2003
TOXICOLOGY REVIEW		FEREAC 72,32570,2007
TOXICOLOGY REVIEW		FEREAC 72,53449,2007
TOXICOLOGY REVIEW		JTPAE7 17,69,2004
TOXICOLOGY REVIEW		REPTED 26,1,2008
TOXICOLOGY REVIEW		ITODC* -,355,2004
TOXICOLOGY REVIEW		HUTOX* -,551,1996
TOXICOLOGY REVIEW		MUREAV 672,10,2009
TOXICOLOGY REVIEW		MUREAV 672,17,2009
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		JTSCDR 34,SP1,2009
TOXICOLOGY REVIEW		FEREAC 73,37850,2008
TOXICOLOGY REVIEW		FESTAS 90,911,2008
TOXICOLOGY REVIEW		MUTAEX 26,19,2011
TOXICOLOGY REVIEW		MUTAEX 26,223,2011
TOXICOLOGY REVIEW		REPTED 31,337,2011
TOXICOLOGY REVIEW		REPTED 31,327,2011
TOXICOLOGY REVIEW		REPTED 38,1,2013
TOXICOLOGY REVIEW		MUTAEX 23,207,2008
TOXICOLOGY REVIEW		MUREAV 763,36,2014
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		TOLED5 201,152,2011
TOXICOLOGY REVIEW		TOLED5 202,36,2011
TOXICOLOGY REVIEW		MUTAEX 30,89,2014
TOXICOLOGY REVIEW		TXCYAC 307,42,2013
TOXICOLOGY REVIEW		TXCYAC 307,123,2013
TOXICOLOGY REVIEW		TXCYAC 307,136,2013
TOXICOLOGY REVIEW		TOLED5 230,146,2014
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		REPTED 54,148,2015
TOXICOLOGY REVIEW		TOLED5 265,106,2017

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,87,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 2 mg/m³, inhal, sen, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 5 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 2 mg/m³, carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 10 mg/m³, short term exposure limit 20 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 5 mg/m³, FEB2006
Occupational Exposure Limit-GERMANY	MAK 2 mg/m³, inhal, 2011
Occupational Exposure Limit-ICELAND	time-weighted average 2 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 5 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 2 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 2 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ATRAZINE-air	10H time-weighted average 5 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 18420; Number of Industries 1; Total Number of Facilities 44; Number of Occupations 9; Total Number of Employees Exposed 1001; Total Number of Female Employees Exposed 123
National Occupational Hazard Survey 1974	Hazard Code 18420; Number of Industries 1; Total Number of Facilities 165; Number of Occupations 2; Total Number of Employees Exposed 331

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB2004/100001)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-reversion; S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8894
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health