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s - Triazine, 2 - chloro - 4,6 - bis (isopropylamino) -

RTECS #: XY5300000

CAS #: 139-40-2


UPDATE: November 2006 MW: 229.75 MF: C9H16ClN5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,3,5 - Triazine - 2,4 - diamine, 6 - chloro - N,N' - bis (1 - methylethyl) -
  2. 2,4 - Bis (isopropylamino) - 6 - chloro - s - triazine
  3. 2,4 - Bis (propylamino) - 6 - chlor - 1,3,5 - triazin (German)
  4. 2 - Chloro - 4,6 - bis (isopropylamino) - s - triazine
  5. 6 - Chloro - N,N' - bis (1 - methylethyl) - 1,3,5 - triazine - 2,4 - diamine
  6. 6 - Chloro - N,N' - diisopropyl - 1,3,5 - triazine - 2,4 - diyldiamine
  7. G - 30028
  8. Geigy 30,028
  9. Gesamil
  1. Milo - pro
  2. Milogard
  3. Plantulin
  4. Primatol P
  5. Propasin
  6. Propazin
  7. Propazine
  8. Propazine (herbicide)
  9. Prozinex


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 6 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** OTS0535303
oral
rabbit
lowest published toxic dose: 2,600 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Abortion FEREAC 70,36164,2005


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 11 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159
oral
rat
lowest published toxic dose: 43,800 mg/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
NTIS** OTS0543186
oral
rat
lowest published toxic dose: 36.5 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors
HBPTO* 2,1514,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >1.22 gm/m3/4 hour N/R FEREAC 70,36159,2005
oral
guinea pig
lethal dose (50 percent kill): 1,200 mg/kg N/R 85GMAT -,35,1982
oral
mouse
lethal dose (50 percent kill): 3,180 mg/kg N/R 85GMAT -,35,1982
oral
rat
lethal dose (50 percent kill): 3,840 mg/kg N/R 85GMAT -,35,1982
subcutaneous
rat
lethal dose (50 percent kill): 395 mg/kg N/R FATOAO 42,163,1979
skin
rat
lethal dose (50 percent kill): >3,100 mg/kg N/R PEMNDP 9,721,1991
skin
rabbit
lethal dose (50 percent kill): >5,050 mg/kg N/R FEREAC 70,36159,2005
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 6 gm/kg N/R GISAAA 44(6),81,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 2,250 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1512,2001
oral
mouse
lowest published toxic dose: 246.37 gm/kg/78 week- continuous Cardiac: Cardiomyopathy including infarction HBPTO* 2,1514,2001
oral
rat
lowest published toxic dose: 4,500 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1512,2001
oral
rat
lowest published toxic dose: 36.5 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
rat
lowest published toxic dose: 1,493.8 mg/kg/14 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TOSCF2 76,190,2003
oral
rat
lowest published toxic dose: 2,134 mg/kg/20 day- intermittent Endocrine: Changes in pituitary weight

Reproductive: Maternal effects: Uterus, cervix, vagina
TOSCF2 76,190,2003
oral
rat
lowest published toxic dose: 2,140 mg/kg/20 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TOXID9 66,343,2002
oral
rabbit
lowest published toxic dose: 650 mg/kg/13 day- intermittent Behavioral: Food intake (animal)

Gastrointestinal: Decreased motility or constipation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 70,36159,2005
skin
rat
lowest published toxic dose: 21,000 mg/kg/21 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 70,36159,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,146,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a preemergence selective herbicide to control annual broadleaf weeds and grasses
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as a preemergence selective herbicide to control annual broadleaf weeds and grasses

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Reproductive Effector

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