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Registry of Toxic Effects of Chemical Substances (RTECS)

s-Triazine, 2-chloro-4,6-bis(isopropylamino)-

RTECS #

XY5300000

CAS #

139-40-2

Updated

November 2006

Molecular Weight

229.75

Molecular Formula

C9H16ClN5

Synonyms

1,3,5-Triazine-2,4-diamine, 6-chloro-N,N'-bis(1-methylethyl)-
2,4-Bis(isopropylamino)-6-chloro-s-triazine
2,4-Bis(propylamino)-6-chlor-1,3,5-triazin (German)
2-Chloro-4,6-bis(isopropylamino)-s-triazine
6-Chloro-N,N'-bis(1-methylethyl)-1,3,5-triazine-2,4-diamine
6-Chloro-N,N'-diisopropyl-1,3,5-triazine-2,4-diyldiamine
G-30028
Geigy 30,028
Gesamil
Milogard
Milo-pro
Plantulin
Primatol P
Propasin
Propazin
Propazine
Propazine (herbicide)
Prozinex

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 6 gm/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** OTS0535303
oral/rabbit 2600 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: AbortionFEREAC 70,36164,2005

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 11 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159
oral/rat lowest published toxic dose: 36.5 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors
HBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 43800 mg/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
NTIS** OTS0543186

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >1.22 gm/m3/4HFEREAC 70,36159,2005
oral/guinea pig lethal dose (50 percent kill): 1200 mg/kg85GMAT -,35,1982
oral/mouse lethal dose (50 percent kill): 3180 mg/kg85GMAT -,35,1982
oral/rat lethal dose (50 percent kill): 3840 mg/kg85GMAT -,35,1982
skin/rabbit lethal dose (50 percent kill): >5050 mg/kgFEREAC 70,36159,2005
skin/rat lethal dose (50 percent kill): >3100 mg/kgPEMNDP 9,721,1991
subcutaneous/rat lethal dose (50 percent kill): 395 mg/kgFATOAO 42,163,1979
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 6 gm/kgGISAAA 44(6),81,1979

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 2250 mg/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1512,2001
oral/mouse lowest published toxic dose: 246.37 gm/kg/78W- continuousCardiac: Cardiomyopathy including infarctionHBPTO* 2,1514,2001
oral/rabbit lowest published toxic dose: 650 mg/kg/13D- intermittentBehavioral: Food intake (animal)

Gastrointestinal: Decreased motility or constipation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 70,36159,2005
oral/rat lowest published toxic dose: 4500 mg/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1512,2001
oral/rat lowest published toxic dose: 36.5 gm/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 1493.8 mg/kg/14D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaTOSCF2 76,190,2003
oral/rat lowest published toxic dose: 2134 mg/kg/20D- intermittentEndocrine: Changes in pituitary weight

Reproductive: Maternal effects: Uterus, cervix, vagina
TOSCF2 76,190,2003
oral/rat lowest published toxic dose: 2140 mg/kg/20D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaTOXID9 66,343,2002
skin/rat lowest published toxic dose: 21000 mg/kg/21D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 70,36159,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,146,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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