Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

s-Triazine, 2-chloro-4,6-bis(ethylamino)-

RTECS #

XY5250000

CAS #

122-34-9; 11141-20-1; 12764-71-5; 39291-64-0; 119603-94-0

Updated

December 2013

Molecular Weight

201.69

Molecular Formula

C7H12ClN5

Synonyms

1,3,5-Triazine-2,4-diamine, 6-chloro-N,N'-diethyl- (9CI)
2,4-Bis(aethylamino)-6-chlor-1,3,5-triazin (German)
2,4-Bis(ethylamino)-6-chloro-s-triazine
2-Chloro-4,6-bis(ethylamino)-1,3,5-triazine
2-Chloro-4,6-bis(ethylamino)-s-triazine
6-Chloro-N,N'-diethyl-1,3,5-triazine-2,4-diamine
A 2079
Aktinit S
Aquazine
Azotop
Batazine FLO
Bitemol S 50
CAT (herbicide)
CDT
Cekusan
Cekusima
Cekuzina-S
CET
G 27692
Geigy 27,692
Gesatop
Gesatop 50
H 1803
Herbatoxol S
Herbazin
Herbazin 50
Herbex (pesticide)
Herboxy
Hungazin DT
Premazine
Primatol S
Princep
Printop
Radocon
Radokor
Simanex
Simatsin-neste
Simazin
Simazine
Simazine 80W
Symazine
Tafazine
Tafazine 50-W
Taphazine
Triazine A 384
W 6658
Yrodazin

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 80 mg moderateCIGET* -,-,1977
skin /rabbit 500 mg open irritation test mildCIGET* -,-,1977

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/human10 ppm/1Y- intermittentMUREAV 537,141,2003
Dominant Lethal Testparenteral/Drosophila melanogaster396 µmol/LJTEHD6 3,691,1977
Dominant Lethal Testoral/Drosophila melanogaster6000 ppmJTEHD6 3,691,1977
mutation in mammalian somatic cellslymphocyte/mouse400 mg/LNTIS** PB84-138973
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster396 µmol/LJTEHD6 3,691,1977
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster2000 ppmJPFCD2 15,867,1980
sister chromatid exchangelymphocyte/human1 mg/LBSIBAC 60,2149,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 17 mg/m3/2H (7-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB277-077
oral/rat 6 gm/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
NTIS** OTS0535324
oral/rabbit 975 mg/kg (7-19D pregnant)Reproductive: Other effects on femaleNNGADV 15,315,1990
oral/rat 3120 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
CHYCDW 15,83,1981
oral/rat 780 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemCHYCDW 15,83,1981
oral/rat 25 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)CHYCDW 15,83,1981
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleNNGADV 15,315,1990

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 4380 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
NTIS** OTS0543187
oral/rat lowest published toxic dose: 36.5 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors
HBPTO* 2,1514,2001
subcutaneous/mouse lowest published toxic dose: 35 gm/kg/87W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
VOONAW 16(1),82,1970
subcutaneous/rat lowest published toxic dose: 16 gm/kg/61W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Tumors at site of application
VOONAW 16(1),82,1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 9800 mg/m3/4HFMCHA2 -,C275,1991
intravenous/mouse lethal dose (50 percent kill): 100 mg/kgCSLNX* NX#04003
oral/chicken lethal dose (50 percent kill): >5 gm/kg85JFAN A369,1984
oral/mammal (species unspecified) lethal dose (50 percent kill): 2014 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Skin and Appendages: Other: Hair
NTIS** PB288-416
oral/mouse lowest published lethal dose: 5 gm/kgBehavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Urine volume increased
GISAAA 27(8),22,1962
oral/pigeon lethal dose (50 percent kill): >5 gm/kg85JFAN A369,1984
oral/rabbit lethal dose (50 percent kill): >5 gm/kg85JFAN A369,1984
oral/rat lethal dose (50 percent kill): 971 mg/kgFAATDF 7,299,1986
skin/rabbit lethal dose (50 percent kill): >10200 mg/kgYKYUA6 37,427,1986
skin/rat lethal dose (50 percent kill): >5 gm/kgNNGADV 15,315,1990
Tank with water/Zebrafish lowest published toxic concentration: 1 mg/L/2DReproductive: Specific developmental abnormalities: Endocrine systemTXAPA9 248,217,2010
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1400 mg/kgGISAAA 44(6),81,1979
unreported route/rat lethal dose (50 percent kill): 1390 mg/kgGTPZAB 7(5),54,1963

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 12.06 gm/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1512,2001
oral/Dog lowest published toxic dose: 4550 mg/kg/13W- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 15,315,1990
oral/Dog lowest published toxic dose: 910 mg/kg/52W- continuousBlood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 15,315,1990
oral/mouse lowest published toxic dose: 79800 mg/kg/95W- continuousBehavioral: Food intake (animal)

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 15,315,1990
oral/mouse lowest published toxic dose: 2100 mg/kg/1W- intermittentEndocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHF8 66,1159,2003
oral/mouse lowest published toxic dose: 72.27 gm/kg/78W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 3869 mg/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 3869 mg/kg/2Y- continuousBlood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 3403.4 mg/kg/0.5Y- continuousEndocrine: Change in LHTOXID9 60,321,2001
oral/rat lowest published toxic dose: 193.75 mg/kg/31D- intermittentEndocrine: AndrogenicTOXID9 90,237,2006
oral/rat lowest published toxic dose: 775 mg/kg/31D- intermittentEndocrine: Androgenic

Reproductive: Other effects on male
TOXID9 90,237,2006
oral/rat lowest published toxic dose: 4650 mg/kg/31D- intermittentEndocrine: Androgenic

Reproductive: Other effects on male

Related to Chronic Data: Changes in prostate weight
TOXID9 90,237,2006
oral/rat lowest published toxic dose: 43680 mg/kg/2Y- continuousBehavioral: Food intake (animal)

Blood: Changes in platelet count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 15,315,1990
oral/rat lowest published toxic dose: 10 gm/kg/7W- intermittentLiver: Other changes

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 7(5),54,1963
oral/rat lowest published toxic dose: 21840 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Other changesNTIS** OTS0555005
oral/rat lowest published toxic dose: 4200 mg/kg/14D- intermittentEndocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHD6 43,155,1994
oral/rat lowest published toxic dose: 1400 mg/kg/14D- intermittentEndocrine: Other changesJTEHD6 43,155,1994
oral/rat lowest published toxic dose: 600 mg/kg/2D- intermittentReproductive: Maternal effects: Uterus, cervix, vagina

Tumorigenic: Cells (cultured) transformed
JTEHF8 43,183,1994
oral/rat lowest published toxic dose: 11.34 gm/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1512,2001

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 73,625,1999
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 53,495,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 53,495,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 73,625,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 73,625,1999
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,258,2005
TOXICOLOGY REVIEWFEREAC 72,32570,2007
TOXICOLOGY REVIEWFEREAC 72,53449,2007
TOXICOLOGY REVIEWHUTOX* -,551,1996
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWFCTOD7 47,2906,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,148,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M4125; Number of Industries 1; Total Number of Facilities 13; Number of Occupations 6; Total Number of Employees Exposed 356
National Occupational Hazard Survey 1974Hazard Code M4125; Number of Industries 1; Total Number of Facilities 29; Number of Occupations 1; Total Number of Employees Exposed 173

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-partial sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000
On EPA IRIS database
TOP