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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Toluidine, N,N-dimethyl-

RTECS #

XU5803000

CAS #

99-97-8

Updated

October 2012

Molecular Weight

135.23

Molecular Formula

C9H13N

Synonyms

Benzenamine, N,N,4-trimethyl-
Dimethyl-p-toluidine
Dimetil-p-toluidina (Italian)
N,N,4-Trimethylaniline
N,N-Dimethyl-p-toluidine
p-(Dimethylamino)toluene
p,N,N-Trimethylaniline

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/rat1082 mg/kgEMMUEG 21,349,1993
DNA Damageintraperitoneal/rat541 mg/kgEMMUEG 21,349,1993
DNA Damageintraperitoneal/mouse135 mg/kgEMMUEG 21,349,1993
micronucleus testlung/hamster900 µmol/LEMMUEG 21,349,1993

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 800 mg/m3/2HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea
TOVEFN (2),44,2006
inhalation/mouse lowest published toxic concentration: 3192 mg/m3/2HEye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TOVEFN (4),30,2007
inhalation/rat lethal concentration (50 percent kill): 1400 mg/m3/4HOlfaction: Ulcerated nasal septum

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory stimulation
NTIS** OTS0573706
inhalation/rat lethal concentration (50 percent kill): 1400 mg/m3/4HHPV300 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 212 mg/kgTOXID9 72,146,2003
ocular/rabbit lowest published toxic dose: 100 mg/kgEye: Lacrimation

Eye: Conjunctiva irritation
TOVEFN (2),44,2006
oral/mouse lethal dose (50 percent kill): 139 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (4),30,2007
oral/mouse lowest published toxic dose: 250 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Kidney, Ureter, and Bladder: Urine volume decreased or anuria
TOXID9 72,146,2003
oral/mouse lethal dose (50 percent kill): 139 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
TOVEFN (2),44,2006
oral/rat lethal dose (50 percent kill): 980 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TOVEFN (2),44,2006
oral/rat lethal dose (50 percent kill): 1650 mg/kgHPV300 -,-,2001
oral/rat lethal dose (50 percent kill): 980 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (4),30,2007
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgHPV300 -,-,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 721,27,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M3033; Number of Industries 42; Total Number of Facilities 2570; Number of Occupations 43; Total Number of Employees Exposed 62720; Total Number of Female Employees Exposed 27118
National Occupational Hazard Survey 1974Hazard Code M3033; Number of Industries 29; Total Number of Facilities 2356; Number of Occupations 19; Total Number of Employees Exposed 31063

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aromatic, 2002
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