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Registry of Toxic Effects of Chemical Substances (RTECS)

o-Toluidine, 4-chloro-

RTECS #

XU5000000

CAS #

95-69-2

Updated

July 2013

Molecular Weight

141.61

Molecular Formula

C7H8ClN

Synonyms

2-Amino-5-chlorotoluene
2-Methyl-4-chloroaniline
3-Chloro-6-aminotoluene
4-Chloro-2-methylaniline
4-Chloro-2-methylbenzeneamine
4-Chloro-2-toluidine
4-Chloro-6-methylaniline
4-Chloro-ortho-toluidine
4-Chloro-o-toluidine
5-Chloro-2-aminotoluene
Benzenamine, 4-chloro-2-methyl- (9CI)
Brentamine Fast Red TR Base
Daito Red Base TR
Diazo Fast Red TRA
Fast Red 5CT Base
Fast Red Base TR
Fast Red TR
Fast Red TRO Base
Kako Red TR Base
Kambamine Red TR
Mitsui Red TR Base
p-Chloro-o-toluidine
Red Base NTR
Red TR Base
Sanyo Fast Red TR Base
Tulabase Fast Red TR

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/mouse600 mg/kgMUREAV 440,1,1999
DNA inhibitionoral/mouse200 mg/kgMUREAV 46,305,1977
DNA repair/Salmonella typhimurium250 mg/discJPFCD2 19,95,1984
DNA repair/Escherichia coli2 gm/discJPFCD2 19,95,1984
mutation in microorganisms/Salmonella typhimurium400 µg/plate (+enzymatic activation step)JPFCD2 19,95,1984
mutation in microorganisms/Salmonella typhimurium200 nmol/plate (-enzymatic activation step)JAFCAU 34,157,1986
other mutation test systemsHeLa cell/human1 mmol/LBECTA6 11,184,1974
Unscheduled DNA Synthesisliver/rat100 µmol/LMUREAV 221,263,1989

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 6720 mg/kg/80W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors
NTIS** OTS0543864

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): 1058 mg/kgNNGADV 1,301,1976
oral/wild bird lethal dose (50 percent kill): 75 mg/kgAECTCV 12,355,1983
subcutaneous/cat lowest published lethal dose: 310 mg/kgBehavioral: Ataxia

Gastrointestinal: Nausea or vomiting

Blood: Methemoglobinemia- Carboxhemoglobinemia
AHBAAM 110,12,1933

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 77,564,2000
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWBCLPT* 96,131,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2A carc, MAY2012
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (12 mg/m3), carc 1, skin, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code T0066; Number of Industries 1; Total Number of Facilities 16; Number of Occupations 1; Total Number of Employees Exposed 250; Total Number of Female Employees Exposed 250
National Occupational Hazard Survey 1974Hazard Code T0066; Number of Industries 2; Total Number of Facilities 77; Number of Occupations 3; Total Number of Employees Exposed 1397

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8896
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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