m-Toluidine

RTECS #

XU2800000

CAS #

108-44-1
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

107.17

Molecular Formula

C₇H₉N

Synonyms

3-Amino-1-methylbenzene
3-Aminophenylmethane
3-Aminotoluen (Czech)
3-Aminotoluene
3-Methylaniline
3-Methylbenzenamine
3-Toluidine
Aniline, 3-methyl-
Benzenamine, 3-methyl- (9CI)
m-Aminotoluene
m-Methylaniline
m-Methylbenzenamine
m-Toluidin (Czech)
m-Toluidine (ACGIH)
m-Toluidyna (Polish)
m-Tolylamine

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	20 mg/24H	moderate	85JCAE -,459,1986
skin /rabbit	500 mg/24H	mild	85JCAE -,459,1986

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	lethal dose (50 percent kill): 116 mg/kg		AISFAR 1,284,1951
intravenous/cat	lowest published toxic dose: 13.4 mg/kg	Blood: Methemoglobinemia- Carboxhemoglobinemia	HPV300 -,-,2001
oral/cat	lethal dose (50 percent kill): >50 mg/kg		NTIS** OTS0573041
oral/mouse	lethal dose (50 percent kill): 740 mg/kg		HPV300 -,-,2001
oral/rabbit	lethal dose (50 percent kill): 750 mg/kg		VINIT* #4035-77
oral/rat	lethal dose (50 percent kill): 450 mg/kg		HPV300 -,-,2001
oral/wild bird	lethal dose (50 percent kill): 242 mg/kg		AECTCV 12,355,1983
skin/rabbit	lethal dose (50 percent kill): 3250 mg/kg		NTIS** OTS0573041
unreported route/rabbit	lethal dose (50 percent kill): 750 mg/kg		HPV300 -,-,2001

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	lowest published toxic dose: 225 mg/kg/3D- continuous	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	HPV300 -,,2001
oral/mouse	lowest published toxic dose: 218400 mg/kg/13W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV300 -,,2001
oral/rat	lowest published toxic dose: 8400 mg/kg/30D- intermittent	Kidney, Ureter, and Bladder: Proteinuria Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VINIT* #4035-77
oral/rat	lowest published toxic dose: 1722 mg/kg/6W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	IJTOFN 24,365,2005
oral/rat	lowest published toxic dose: 1230 mg/kg/30D- continuous	Liver: Other changes Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	IJTOFN 24,365,2005
oral/rat	lowest published toxic dose: 8400 mg/kg/30D- continuous	Endocrine: Changes in spleen weight Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV300 -,,2001
oral/rat	lowest published toxic dose: 10920 mg/kg/90D- continuous	Endocrine: Changes in spleen weight Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV300 -,,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2 ppm (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		ENTOX* -,206,2005

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 2 ppm (8.8 mg/m³), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 2 ppm (9 mg/m³);KZW 4 ppm (18 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 2 ppm (8.9 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 2 ppm (9 mg/m³), skin, MAY2011
Occupational Exposure Limit-HUNGARY	time-weighted average 9 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 2 ppm (9 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 2 ppm (9 mg/m³), skin, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 2 ppm (8.8 mg/m³), skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 2 ppm (8,8 mg/m³), JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 2 ppm (9 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 9 mg/m³, Skin, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Hazard Survey 1974	Hazard Code 81889; Number of Industries 3; Total Number of Facilities 257; Number of Occupations 3; Total Number of Employees Exposed 2876

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID-73

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health