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Registry of Toxic Effects of Chemical Substances (RTECS)

Toluene, alpha,alpha,alpha-trichloro-

RTECS #

XT9275000

CAS #

98-07-7

Updated

September 201

Molecular Weight

195.47

Molecular Formula

C7H5Cl3

Synonyms

1-(Trichloromethyl)benzene
alpha,alpha,alpha-Trichlorotoluene
Benzene, (trichloromethyl)-
Benzenyl chloride
Benzenyl trichloride
Benzoic trichloride
Benzotrichloride
Benzyl trichloride
Benzylidyne chloride
Chlorure de benzenyle (French)
omega,omega,omega-Trichlorotoluene
Phenyl chloroform
Phenyltrichloromethane
RCRA waste number U023
Toluene trichloride
Trichloormethylbenzeen (Dutch)
Trichlormethylbenzol (German)
Trichloromethylbenzene
Trichlorophenylmethane
Triclorometilbenzene (Italian)
Triclorotoluene (Italian)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/rat1 ppm/6H/4W- intermittentMUREAV 164,272,1986
DNA Damageother cell types/human100 µg/LPAACA3 27,94,1986
DNA repair/Bacillus subtilis2600 nmol/discMUREAV 58,143,1978
mutation in microorganisms/Salmonella typhimurium10 µg/plate (+enzymatic activation step)EMMUEG 11(Suppl 12),1,1988
mutation in microorganisms/Salmonella typhimurium500 nmol/plate/20M (-enzymatic activation step)MUREAV 58,143,1978
mutation in microorganisms/Escherichia coli500 nmol/plate/20M (+enzymatic activation step)MUREAV 58,143,1978

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 1620 ppb/30M/22W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
SAIGBL 28,352,1986
intraperitoneal/mouse toxic dose: 288 mg/kg/8W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
PAACA3 27,94,1986
intraperitoneal/mouse toxic dose: 1440 mg/kg/8W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Blood: Lymphoma including Hodgkin's disease
CALEDQ 33,167,1986
intraperitoneal/mouse lowest published toxic dose: 287 mg/kg/8W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CALEDQ 33,167,1986
oral/mouse lowest published toxic dose: 1380 mg/kg/25W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
INHEAO 31,127,1993
skin/mouse toxic dose: 16320 mg/kg/31W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
GANNA2 72,655,1981
skin/mouse toxic dose: 17600 mg/kg/42W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
GANNA2 72,655,1981
skin/mouse toxic dose: 34000 mg/kg/31W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
GANNA2 72,655,1981
skin/mouse toxic dose: 35200 mg/kg/42W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors
GANNA2 72,655,1981
skin/mouse lowest published toxic dose: 9200 mg/kg/50W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
GANNA2 72,655,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 60 mg/m3GTPZAB 30(3),6,1986
inhalation/mouse lethal concentration (50 percent kill): 60 mg/m3/2HVCVGK* -,42,1984
inhalation/mouse lethal concentration (50 percent kill): 8 ppm/2HBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression
IMEMDT 29,73,1982
inhalation/mouse lethal concentration (50 percent kill): 0.06 gm/m3TPKVAL 9,27,1967
inhalation/rat lethal concentration (50 percent kill): 0.15 gm/m3TPKVAL 9,27,1967
inhalation/rat lethal concentration (50 percent kill): 19 ppm/2HBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
IMEMDT 29,73,1982
inhalation/rat lethal concentration (50 percent kill): 150 mg/m3/2HVCVGK* -,42,1984
oral/mammal (species unspecified) lethal dose (50 percent kill): 1300 mg/kgGISAAA 40(1),92,1975
oral/mouse lethal dose (50 percent kill): 702 mg/kgTSCAT* FYI-OTS-1180-0107
oral/rat lethal dose (50 percent kill): 1300 mg/kgVCVGK* -,42,1984
skin/rabbit lethal dose (50 percent kill): 4 gm/kgBehavioral: Excitement

Liver: Other changes

Skin: After systemic exposure: Dermatitis, other
TSCAT* FYI-OTS-1180-0107
subcutaneous/frog lowest published lethal dose: 2150 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Change in motor activity (specific assay)
AEPPAE 130,250,1928
unreported route/rat lethal dose (50 percent kill): 1300 mg/kgBehavioral: Somnolence (general depressed activity)

Vascular: Other changes

Lung, Thorax, or Respiration: Respiratory stimulation
TPKVAL 10,131,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 100 mg/m3/2H/9W- intermittentBrain and Coverings: Other degenerative changes

Vascular: BP lowering not characterized in autonomic section

Blood: Luekopenia
GISAAA 28(10),30,1963
inhalation/rat lowest published toxic concentration: 49 mg/m3/4W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** OTS0536269
inhalation/rat lowest published toxic concentration: 100 mg/m3/2H/7D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,43,1994
inhalation/rat lowest published toxic concentration: 30 mg/m3/2H/20D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionVCVGK* -,43,1994
oral/rat lowest published toxic dose: 0.84 mg/kg/28D- continuousLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
VCVGK* -,43,1994
skin/rabbit lowest published toxic dose: 1500 mg/kg/3D- intermittentBlood: Changes in leukocyte (WBC) count

Skin: After topical application: Corrosive

Skin and Appendages: Other: Hair
VCVGK* -,43,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.1 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 29,73,1982
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,453,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 71,453,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 29,73,1982
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 0.012 ppm (0.1 mg/m3);KZW 0.048 ppm (0.4 mg/m3), 2007
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.1 ppm (0.81 mg/m3), Skin, Carcinogen, MAR2002
Occupational Exposure Limit-JAPAN1 carc, MAY2012
Occupational Exposure Limit-NEW ZEALANDskin, JAN2002
Occupational Exposure Limit-RUSSIAtime-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.012 ppm (0.1 mg/m3), carc 2, skin, JAN2011
Occupational Exposure Limit-SWITZERLANDcarc 1, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7402; Number of Industries 1; Total Number of Facilities 43; Number of Occupations 1; Total Number of Employees Exposed 171

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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