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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Toluenesulfonic acid

RTECS #

XT6300000

CAS #

104-15-4; 402-47-1; 100901-72-2; 114213-96-6; 126033-27-0; 128739-80-0; 144647-92-7; 156627-46-2

Updated

April 2010

Molecular Weight

172.21

Molecular Formula

C7H8O3S

Synonyms

4-Methylbenzenesulfonic acid
4-Toluenesulfonic acid
Benzenesulfonic acid, 4-methyl- (9CI)
Cyzac 4040
K-Cure 1040
Kyselina p-toluensulfonova (Czech)
Manro PTSA 65 E
Manro PTSA 65 H
Manro PTSA 65 LS
p-Methylbenzenesulfonic acid
p-Methylphenylsulfonic acid
p-Toluenesulphonic acid
p-Tolylsulfonic acid
Toluenesulfonic acid
Tosic acid
TSA-HP
TSA-MH

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg severeHPV326 -,-,2007

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 15 mg/m3Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Other changes
TOVEFN (6),54,2003
inhalation/rat lowest published toxic concentration: 36 mg/m3Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Proteinuria
TOVEFN (6),54,2003
inhalation/rat lowest published toxic concentration: 36 mg/m3Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesTOVEFN (6),54,2003
oral/mouse lethal dose (50 percent kill): 735 mg/kgBehavioral: Somnolence (general depressed activity)TOVEFN (6),54,2003
oral/quail lethal dose (50 percent kill): >316 mg/kgEESADV 6,149,1982
oral/rat lethal dose (50 percent kill): 2480 mg/kg85JCAE -,1055,1986
oral/rat lethal dose (50 percent kill): 1410 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Ulceration or bleeding from stomach
HPV127 -,-,2003
oral/rat lethal dose (50 percent kill): 1410 mg/kgGastrointestinal: Ulceration or bleeding from stomach

Blood: Hemorrhage
HPV326 -,-,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,341,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81921; Number of Industries 59; Total Number of Facilities 2703; Number of Occupations 67; Total Number of Employees Exposed 87942; Total Number of Female Employees Exposed 19232
National Occupational Hazard Survey 1974Hazard Code 81921; Number of Industries 41; Total Number of Facilities 3642; Number of Occupations 44; Total Number of Employees Exposed 56637

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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