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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Toluenesulfonamide, N-chloro-, sodium salt

RTECS #

XT5616800

CAS #

127-65-1

Updated

October 2012

Molecular Weight

228.66

Molecular Formula

C7H8ClNO2S·Na

Synonyms

Acti-chlore
Aktivin
Anexol
Benzenesulfonamide, N-chloro-4-methyl-, sodium salt (9CI)
Berkendyl
Chloralone
Chloramine T
Chlorasan
Chloraseptine
Chlorazan
Chlorazene
Chlorazone
Chlorozone
Chlorseptol
Clorina
Clorosan
Desinfect
Euclorina
Gansil
Gyneclorina
Halamid
Heliogen
Kloramin
Kloramine-T
Multichlor
N-Chloro-4-methylbenzenesulfonamide sodium salt
Sodium chloramine T
Sodium p-toluenesulfonylchloramide
Sodium tosylchloramide
Tampules
Tochlorine
Tolamine
Tosylchloramide sodium

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human100 ppm/24HARMCAH 21,409,1970
phage inhibition capacity/Escherichia coli255 µg/wellMUREAV 260,349,1991

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intracerebral/rat lowest published toxic dose: 91.464 µg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase
NRTXDN 32,199,2011
intracerebral/rat lowest published toxic dose: 18.292 gm/kgBrain and Coverings: Recordings from specific areas of CNS

Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase
NRTXDN 32,199,2011
intravenous/rabbit lowest published lethal dose: 25 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis
JPETAB 14,259,1920
parenteral/frog lowest published lethal dose: 200 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 14,259,1920
parenteral/mouse lowest published lethal dose: 300 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 14,259,1920
subcutaneous/guinea pig lowest published lethal dose: 900 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle weakness
JPETAB 14,259,1920

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intravenous/Dog lowest published toxic dose: 186 mg/kg/16W- intermittentLung, Thorax, or Respiration: EmphysemaNTIS** LMF-102

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83916; Number of Industries 7; Total Number of Facilities 190; Number of Occupations 8; Total Number of Employees Exposed 1829; Total Number of Female Employees Exposed 1284
National Occupational Hazard Survey 1974Hazard Code 83916; Number of Industries 2; Total Number of Facilities 93; Number of Occupations 5; Total Number of Employees Exposed 378

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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