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p - Toluenesulfonamide, N - chloro - , sodium salt

RTECS #: XT5616800

CAS #: 127-65-1


UPDATE: September 1998 MW: 228.66 MF: C7H8ClNO2SNa


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Acti - chlore
  2. Aktivin
  3. Anexol
  4. Benzenesulfonamide, N - chloro - 4 - methyl - , sodium salt (9CI)
  5. Berkendyl
  6. Chloralone
  7. Chloramine T
  8. Chlorasan
  9. Chloraseptine
  10. Chlorazan
  11. Chlorazene
  12. Chlorazone
  13. Chlorozone
  14. Chlorseptol
  15. Clorina
  16. Clorosan
  17. Desinfect
  1. Euclorina
  2. Gansil
  3. Gyneclorina
  4. Halamid
  5. Heliogen
  6. Kloramin
  7. Kloramine - T
  8. Multichlor
  9. N - Chloro - 4 - methylbenzenesulfonamide sodium salt
  10. Sodium chloramine T
  11. Sodium p - toluenesulfonylchloramide
  12. Sodium tosylchloramide
  13. Tampules
  14. Tochlorine
  15. Tolamine
  16. Tosylchloramide sodium


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 100 ppm/24 hour ARMCAH 21,409,1970
phage inhibition capacity Escherichia coli 255 g/well MUREAV 260,349,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
rabbit
lowest published lethal dose: 25 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis
JPETAB 14,259,1920
parenteral
frog
lowest published lethal dose: 200 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 14,259,1920
parenteral
mouse
lowest published lethal dose: 300 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 14,259,1920
subcutaneous
guinea pig
lowest published lethal dose: 900 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle weakness
JPETAB 14,259,1920


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
dog
lowest published toxic dose: 186 mg/kg/16 week- intermittent Lung, Thorax, or Respiration: Emphysema NTIS** LMF-102


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83916;
Number of Industries 2;
Total Number of Facilities 93;
Number of Occupations 5;
Total Number of Employees Exposed 378
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83916;
Number of Industries 7;
Total Number of Facilities 190;
Number of Occupations 8;
Total Number of Employees Exposed 1,829;
Total Number of Female Employees Exposed 1,284


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ARMCAH Annual Review of Medicine. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1950-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Mutagen
   Human Data

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