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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Toluenesulfonamide

RTECS #

XT5075000

CAS #

70-55-3

Updated

November 2009

Molecular Weight

171.23

Molecular Formula

C7H9NO2S

Synonyms

4-Methylbenzenesulfonamide
4-Toluenesulfanamide
Benzenesulfonamide, 4-methyl- (9CI)
Plasticizer 15
p-Methylbenzenesulfonamide
p-Toluenesulfanamide
p-Toluenesulfonylamide
p-Tolylsulfonamide
p-Tosylamide
Toluene-4-sulfonamide
Toluene-p-sulphonamide
Tolylsulfonamide
Tosylamide
Uniplex 173

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium40 µmol/plate (-enzymatic activation step)45OHAA -,170,1980
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster2500 µmol/plate45OHAA -,170,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 29250 mg/kg (14D pre-3D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
HPV135 -,-,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 250 mg/kgNTIS** AD691-490
oral/wild bird lethal dose (50 percent kill): 75 mg/kgTXAPA9 21,315,1972
subcutaneous/guinea pig lowest published lethal dose: 2 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle weakness
JPETAB 14,259,1920

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 11700 mg/kg/39D- intermittentKidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Endocrine: Changes in thymus weight
HPV135 -,-,2008

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1329; Number of Industries 8; Total Number of Facilities 304; Number of Occupations 16; Total Number of Employees Exposed 9023; Total Number of Female Employees Exposed 1223
National Occupational Hazard Survey 1974Hazard Code A1329; Number of Industries 5; Total Number of Facilities 195; Number of Occupations 29; Total Number of Employees Exposed 4613

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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