Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

o-Toluenesulfonamide

RTECS #

XT4900000

CAS #

88-19-7

Updated

November 2009

Molecular Weight

171.23

Molecular Formula

C7H9NO2S

Synonyms

2-Methylbenzenesulfonamide
2-Tolylsulfonamide
Benzenesulfonamide, 2-methyl-
o-Methylbenzenesulfonamide
ortho-Toluol-sulfonamid (German)
Toluene-2-sulfonamide

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,1073,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium70 µmol/plate (-enzymatic activation step)45OHAA -,170,1980
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster5 mmol/LMUREAV 56,163,1977
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster2500 µmol/L45OHAA -,170,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 4300 mg/kg (1-22D preg/21D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TXAPA9 51,455,1979
oral/mouse 1 gm/kg (10D pregnant)Reproductive: Effects on fertility: Other measures of fertilityPCBRD2 109,339,1982
oral/rat 19500 mg/kg (14D pre-3D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)HPV135 -,-,2008

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 13 gm/kg/96W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Kidney, Ureter, and Bladder: Kidney tumors
ZKKOBW 91,19,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): 4870 mg/kg85JCAE -,1073,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 780 mg/kg/39D- intermittentLiver: Changes in liver weight

Endocrine: Changes in thymus weight
HPV135 -,-,2008
oral/rat lowest published toxic dose: 19500 mg/kg/39D- intermittentLiver: Changes in liver weight

Endocrine: Changes in thymus weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV135 -,-,2008

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 22,111,1980
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,334,1987
TOXICOLOGY REVIEWMUREAV 584,1,2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1103; Number of Industries 4; Total Number of Facilities 121; Number of Occupations 4; Total Number of Employees Exposed 975; Total Number of Female Employees Exposed 272

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP