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Registry of Toxic Effects of Chemical Substances (RTECS)

Toluene, 3,4-dinitro-

RTECS #

XT2100000

CAS #

610-39-9

Updated

April 2012

Molecular Weight

182.15

Molecular Formula

C7H6N2O4

Synonyms

3,4-Dinitrotoluene
3,4-DNT
4-Methyl-1,2-dinitrobenzene
Benzene, 4-methyl-1,2-dinitro- (9CI)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H mildNTIS** AD-B011-150

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageliver/rat300 µmol/LSinJF# 26OCT1982
mutation in microorganisms/Salmonella typhimurium1 mg/plate (+enzymatic activation step)NTIS** AD-A080-146
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)ENMUDM 4,163,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 747 mg/kgBehavioral: Somnolence (general depressed activity)NTIS** AD-A080-146
oral/rat lethal dose (50 percent kill): 807 mg/kgNTIS** AD-A080-146

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,60,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 1.5 mg/m3;KZW 6 mg/m3, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 0.15 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg/m3, skin, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.15 mg/m3, skin, sen, NOV2011
Occupational Exposure Limit-MEXICOtime-weighted average 1.5 mg/m3;short term exposure limit 5 mg/m3 (skin), 2004

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 3,4-DINITROTOLUENE-air10H Carcinogen time-weighted average 1.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #44
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