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Registry of Toxic Effects of Chemical Substances (RTECS)

Toluene, 2,6-dinitro-

RTECS #

XT1925000

CAS #

606-20-2

Updated

July 2013

Molecular Weight

182.15

Molecular Formula

C7H6N2O4

Synonyms

1-Methyl-2,6-dinitrobenzene
2,6-Dinitrotoluene
2,6-DNT
2-Methyl-1,3-dinitrobenzene
Benzene, 2-methyl-1,3-dinitro- (9CI)
RCRA waste number U106

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H mildNTIS** AD-B011-150

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/mouse75 mg/kgCALEDQ 52,13,1990
body fluid assaySalmonella typhimurium/rat75 mg/kgCALEDQ 52,13,1990
Cytogenetic Analysisoral/rat1260 mg/kg/6W-continuousNTIS** AD-A062-015
DNA adductskin/mouse192 µmol/kgCRNGDP 5,231,1984
DNA adductintraperitoneal/rat219 µg/kgMUREAV 301,79,1993
DNA adductoral/rat10 mg/kgJTEHD6 11,555,1983
DNA Damageliver/rat3 mmol/LSinJF# 26OCT1982
DNA Damageoral/rat300 mg/kg/3D- intermittentMUREAV 702,40,2010
DNA Damageoral/rat957 mg/kg/29D- intermittentMUREAV 702,40,2010
DNA Damagetestis/rat0.032 µmol/LEMMUEG 44,179,2004
DNA inhibitionintraperitoneal/rat20 mg/kg/8W- intermittentCBTOE2 7,111,1991
micronucleus testoral/rat125 mg/kgMUREAV 698,30,2010
micronucleus testoral/rat100 mg/kg/2D- intermittentMUREAV 698,24,2010
micronucleus testoral/rat300 mg/kg/3D- intermittentMUREAV 702,40,2010
morphological transformoral/rat58800 µg/kg/3W-continuousCRNGDP 7,1797,1986
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)DTESD7 2,249,1977
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)SAIGBL 29,34,1987
other mutation test systemsoral/rat10 mg/kgJTEHD6 11,555,1983
Unscheduled DNA Synthesisother cell types/rat10 µmol/LCBTOE2 7,111,1991
Unscheduled DNA Synthesisoral/rat5 mg/kgCRNGDP 3,241,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 2555 mg/kg/1Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JJIND8 79,1313,1987
oral/rat toxic dose: 5110 mg/kg/1Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
PAACA3 24,91,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 240 mg/m3/6HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Fibrosing alveolitis

Lung, Thorax, or Respiration: Changes in lung weight
NTIS** OTS0533663
oral/mouse lethal dose (50 percent kill): 621 mg/kgBehavioral: Somnolence (general depressed activity)NTIS** AD-A080-146
oral/mouse lethal dose (50 percent kill): 714 mg/kgENTOX* -,60,2005
oral/rat lethal dose (50 percent kill): 177 mg/kgNTIS** PB214-270

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 9 gm/kg/90D- continuousBlood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 37,116,1976
oral/mouse lowest published toxic dose: 27 gm/kg/90D- continuousBlood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 37,116,1976
oral/rat lowest published toxic dose: 13500 mg/kg/90D- intermittentBlood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 37,116,1976
oral/rat lowest published toxic dose: 300 mg/kg/3D- intermittentLiver: Other changesMUREAV 702,40,2010
oral/rat lowest published toxic dose: 957 mg/kg/29D- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
MUREAV 702,40,2010

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 65,309,1996
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 65,309,1996
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 65,309,1996
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 588,88,2005
TOXICOLOGY REVIEWENTOX* -,60,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWMUREAV 723,108,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 0.007 ppm (0.05 mg/m3);KZW 0.028 ppm (0.2 mg/m3), 2007
Occupational Exposure Limit-DENMARKtime-weighted average 0.15 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg/m3, skin, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.15 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 1.5 mg/m3;short term exposure limit 5 mg/m3 (skin), 2004
Occupational Exposure Limit-PERUtime-weighted average 0.15 mg/m3, JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 0.15 mg/m3;short term exposure limit 0.3 mg/m3, Carcinogen, Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.007 ppm (0.05 mg/m3), carc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,6-DINITROTOLUENE-air10H Carcinogen time-weighted average 1.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/122004)
EPA GENETOX PROGRAM 1988, Inconclusive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #44
On EPA IRIS database
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