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Toluene, 2,6 - dinitro -

RTECS #: XT1925000

CAS #: 606-20-2


UPDATE: May 2008 MW: 182.15 MF: C7H6N2O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Methyl - 2,6 - dinitrobenzene
  2. 2,6 - DNT
  3. 2,6 - Dinitrotoluene
  1. 2 - Methyl - 1,3 - dinitrobenzene
  2. Benzene, 2 - methyl - 1,3 - dinitro - (9CI)
  3. RCRA waste number U106


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg/24 hour mild NTIS** AD-B011-150


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay mouse
Salmonella typhimurium
75 mg/kg CALEDQ 52,13,1990
body fluid assay rat
Salmonella typhimurium
75 mg/kg CALEDQ 52,13,1990
cytogenetic analysis oral
rat
1,260 mg/kg/6 week- continuous NTIS** AD-A062-015
DNA adduct skin
mouse
192 µmol/kg CRNGDP 5,231,1984
DNA adduct intraperitoneal
rat
219 µg/kg MUREAV 301,79,1993
DNA adduct oral
rat
10 mg/kg JTEHD6 11,555,1983
DNA damage rat liver 3 mmol/L SinJF# 26OCT1982
DNA damage rat testis 0.32 µmol/L EMMUEG 44,179,2004
DNA inhibition intraperitoneal
rat
20 mg/kg/8 week- intermittent CBTOE2 7,111,1991
unscheduled DNA synthesis rat other cell types 10 µmol/L CBTOE2 7,111,1991
unscheduled DNA synthesis oral
rat
5 mg/kg CRNGDP 3,241,1982
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) DTESD7 2,249,1977
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) SAIGBL 29,34,1987
morphological transform oral
rat
58,800 µg/kg/3 week- continuous CRNGDP 7,1797,1986
other mutation test systems oral
rat
10 mg/kg JTEHD6 11,555,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 2,555 mg/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JJIND8 79,1313,1987
oral
rat
toxic dose : 5,110 mg/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
PAACA3 24,91,1983


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 240 mg/m3/6 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Fibrosing alveolitis

Lung, Thorax, or Respiration: Changes in lung weight
NTIS** OTS0533663
oral
mouse
lethal dose (50 percent kill): 621 mg/kg Behavioral: Somnolence (general depressed activity) NTIS** AD-A080-146
oral
mouse
lethal dose (50 percent kill): 714 mg/kg N/R ENTOX* -,60,2005
oral
rat
lethal dose (50 percent kill): 177 mg/kg N/R NTIS** PB214-270


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 9 gm/kg/90 day- continuous Blood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 37,116,1976
oral
mouse
lowest published toxic dose: 27 gm/kg/90 day- continuous Blood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 37,116,1976
oral
rat
lowest published toxic dose: 13,500 mg/kg/90 day- intermittent Blood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 37,116,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 65,309,1996
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,309,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 65,309,1996
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
MUREAV 588,88,2005
TOXICOLOGY REVIEW
ENTOX* -,60,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA TRK 0.05 mg/m3 (0.007 mL/m3), JAN 2006
Occupational Exposure Limit - DENMARK time-weighted average 0.15 mg/m3, OCT 2002
Occupational Exposure Limit - MEXICO time-weighted average 1.5 mg/m3;
short term exposure limit 5 mg/m3 (skin), 2004
Occupational Exposure Limit - SWEDEN time-weighted average 0.15 mg/m3;
short term exposure limit 0.3 mg/m3, Carcinogen, Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.007 ppm (0.05 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,6-DINITROTOLUENE-air Carcinogen;
10 hour time-weighted average 1.5 mg/m3 (Sk)
NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/122004)
EPA GENETOX PROGRAM 1988, Inconclusive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #44


REFERENCES:

CODEN
REFERENCE

CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier Science, New York, NY) V.1-15, 1977-87. Discontinued
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

NIOSH PROFILE (NITROTOLUENES), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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