Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Toluene, 2,3-dinitro-

RTECS #

XT1400000

CAS #

602-01-7

Updated

April 2012

Molecular Weight

182.15

Molecular Formula

C7H6N2O4

Synonyms

1-Methyl-2,3-dinitrobenzene
2,3-Dinitrotoluene
2,3-Dinitrotoluol
2,3-DNT
Benzene, 1-methyl-2,3-dinitro- (9CI)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H mildNTIS** AD-B011-150

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageliver/rat300 µmol/LSinJF# 26OCT1982
mutation in microorganisms/Salmonella typhimurium50 µg/plate (+enzymatic activation step)ENMUDM 4,163,1982
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)NTIS** AD-A080-146

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 1072 mg/kgNTIS** PB214-270
oral/rat lethal dose (50 percent kill): 911 mg/kgBehavioral: Somnolence (general depressed activity)NTIS** AD-A080-146

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,60,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg/m3, skin, NOV2011
Occupational Exposure Limit-MEXICOtime-weighted average 1.5 mg/m3;short term exposure limit 5 mg/m3 (skin), 2004

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,3-DINITROTOLUENE-air10H Carcinogen time-weighted average 1.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #44
TOP