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Toluene, 2,3 - dinitro -

RTECS #: XT1400000

CAS #: 602-01-7


UPDATE: November 2007 MW: 182.15 MF: C7H6N2O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Methyl - 2,3 - dinitrobenzene
  2. 2,3 - DNT
  3. 2,3 - Dinitrotoluene
  1. 2,3 - Dinitrotoluol
  2. Benzene, 1 - methyl - 2,3 - dinitro - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg/24 hour mild NTIS** AD-B011-150


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage rat liver 300 µmol/L SinJF# 26OCT1982
mutation in microorganisms Salmonella typhimurium 50 µg/plate (+enzymatic activation step) ENMUDM 4,163,1982
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) NTIS** AD-A080-146


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lethal dose (50 percent kill): 1,072 mg/kg N/R NTIS** PB214-270
oral
rat
lethal dose (50 percent kill): 911 mg/kg Behavioral: Somnolence (general depressed activity) NTIS** AD-A080-146


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ENTOX* -,60,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 0.15 mg/m3, OCT 2002
Occupational Exposure Limit - MEXICO time-weighted average 1.5 mg/m3;
short term exposure limit 5 mg/m3 (skin), 2004


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,3-DINITROTOLUENE-air Carcinogen;
10 hour time-weighted average 1.5 mg/m3 (Sk)
NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #44


REFERENCES:

CODEN
REFERENCE

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982

RTECS Compound Description:
   Mutagen
   Primary Irritant

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