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Registry of Toxic Effects of Chemical Substances (RTECS)

Toluene-2,6-diamine

RTECS #

XS9750000

CAS #

823-40-5

Updated

July 2012

Molecular Weight

122.19

Molecular Formula

C7H10N2

Synonyms

1,3-Benzenediamine, 2-methyl-
2,6-Diaminotoluene
2,6-Toluylenediamine
2,6-Tolylenediamine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster10 mmol/LMUREAV 265,45,1992
DNA Damageoral/rat1500 mg/kg/3D- intermittentMUREAV 702,40,2010
DNA Damageoral/rat1740 mg/kg/29D- intermittentMUREAV 702,40,2010
DNA inhibitionintraperitoneal/mouse30 mg/kgMUREAV 91,75,1981
micronucleus testovary/hamster100 mg/LEMMUEG 26,240,1995
micronucleus testoral/rat300 mg/kgCRNGDP 12,2233,1991
mutation in microorganisms/Salmonella typhimurium100 µg/plate (-enzymatic activation step)ESKGA2 31,113,1985
Unscheduled DNA Synthesisliver/human10 µmol/LCNREA8 49,1075,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1500 mg/kg/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldMUREAV 702,40,2010
oral/rat lowest published toxic dose: 1740 mg/kg/29D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldMUREAV 702,40,2010

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWEMMUEG 43,36,2004
TOXICOLOGY REVIEWMUREAV 588,88,2005
TOXICOLOGY REVIEWMUREAV 590,1,2005
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUREAV 721,27,2011

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 2,6-Toluenediamine, 5516
OSHA ANALYTICAL METHOD #ID-65
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