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Registry of Toxic Effects of Chemical Substances (RTECS)

Toluene, p-chloro-

RTECS #

XS9010000

CAS #

106-43-4

Updated

April 2012

Molecular Weight

126.59

Molecular Formula

C7H7Cl

Synonyms

4-Chloro-1-methylbenzene
4-Chlorotoluene
Benzene, 1-chloro-4-methyl- (9CI)
p-Tolyl chloride

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 34 gm/m3/2H85GMAT -,38,1982
oral/mouse lethal dose (50 percent kill): 1900 mg/kg85GMAT -,38,1982
oral/rat lethal dose (50 percent kill): 1900 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Gastritis
HPV080 -,-,2001
oral/rat lethal dose (50 percent kill): 2100 mg/kgBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
TSCAT* OTS0513162
unreported route/guinea pig lethal dose (50 percent kill): 3750 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 46(2),67,1981
unreported route/mouse lethal dose (50 percent kill): 4 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 46(2),67,1981
unreported route/rat lethal dose (50 percent kill): 4 gm/kgGISAAA 45(12),64,1980

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 182 mg/kg/26W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Liver function tests impaired
GISAAA 46(2),67,1981
oral/rat lowest published toxic dose: 25200 mg/kg/2W- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JACTDZ 9(5),487,1990
oral/rat lowest published toxic dose: 72 gm/kg/90D- intermittentLiver: Changes in liver weight

Endocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JACTDZ 9(5),487,1990
oral/rat lowest published toxic dose: 25200 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV080 -,-,2001

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (260 mg/m3), short term exposure limit 75 ppm (390 mg/m3), NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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