Toluene, p-tert-butyl-

RTECS #

XS8400000

CAS #

98-51-1
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

148.27

Molecular Formula

C₁₁H₁₆

Synonyms

1-Methyl-4-tert-butylbenzene
4-tert-Butyltoluene
Benzene, 1-methyl-4-(1,1-dimethylethyl)- (9CI)
p-Methyl-tert-butylbenzene
p-tert-Butyltoluene
p-tert-Butyltoluene (ACGIH:OSHA)
TBT

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	5 ppm/2H		AMIHBC 9,227,1954
eye /rabbit	100 mg		AMIHBC 9,227,1954
skin /rabbit	500 mg/24H	mild	AMIHBC 9,227,1954

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 10 ppm/3M	Gastrointestinal: Nausea or vomiting	AMIHBC 9,227,1954
inhalation/human	lowest published toxic concentration: 20 ppm/5M	Eye: Conjunctiva irritation Taste: Change in function Gastrointestinal: Nausea or vomiting	28ZRAQ -,156,1960
inhalation/mouse	lethal concentration (50 percent kill): 248 ppm/4H	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Excitement	AMIHBC 9,227,1954
inhalation/rat	lethal concentration (50 percent kill): 165 ppm/8H	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands	AMIHBC 9,227,1954
intraperitoneal/rat	lethal dose (50 percent kill): 275 mg/kg		VCVGH* -,184,1990
intraperitoneal/rat	lethal dose (16 percent kill): 188 mg/kg		VCVGH* -,184,1990
intraperitoneal/rat	lethal dose (84 percent kill): 545 mg/kg		VCVGH* -,184,1990
oral/mouse	lethal dose (50 percent kill): 778 mg/kg	Behavioral: Muscle weakness Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression	AMIHBC 9,227,1954
oral/rabbit	lethal dose (50 percent kill): 1728 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness	AMIHBC 9,227,1954
oral/rat	lethal dose (50 percent kill): 1555 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	AMIHBC 9,227,1954
oral/rat	lethal dose (50 percent kill): 1600 mg/kg		VCVGH* -,184,1990
skin/rabbit	lethal dose (50 percent kill): 16934 mg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Body temperature decrease	AMIHBC 9,227,1954

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 20 ppm/6H/14D- intermittent	Brain and Coverings: Recordings from specific areas of CNS	PHTOEH 76,36,1995
inhalation/rat	lowest published toxic concentration: 850 ppm/1H/5D- intermittent	Autonomic Nervous System: Other (direct) parasympathomimetic Lung, Thorax, or Respiration: Acute pulmonary edema Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHBC 9,227,1954
inhalation/rat	lowest published toxic concentration: 50 ppm/2H/26W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in leukocyte (WBC) count	AMIHBC 9,227,1954
inhalation/rat	lowest published toxic concentration: 25 ppm/2H/73D- intermittent	Liver: Changes in liver weight	AMIHBC 9,227,1954
inhalation/rat	lowest published toxic concentration: 50 ppm/7H/37D- intermittent	Liver: Changes in liver weight	AMIHBC 9,227,1954
inhalation/rat	lowest published toxic concentration: 20 ppm/4W- intermittent	Brain and Coverings: Recordings from specific areas of CNS Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Other proteins	PHTOEH 87,11,2000
inhalation/rat	lowest published toxic concentration: 40 ppm/4W- intermittent	Brain and Coverings: Recordings from specific areas of CNS Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS	PHTOEH 87,11,2000

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 ppm	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 10 ppm (60 mg/m³)	DTLVS* 3,34,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 ppm (61 mg/m³), short term exposure limit 20 ppm (121 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 10 ppm (60 mg/m³);KZW 10 ppm (60 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 ppm (6.2 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 ppm (6.1 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 1 ppm (6.1 mg/m³), ceiling concentration 5 ppm (31 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 10 ppm (60 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 1 ppm (6.1 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 10 ppm (60 mg/m³), short term exposure limit 20 ppm (120 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 ppm (60 mg/m³);short term exposure limit 20 ppm (120 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 ppm (61 mg/m³); short term exposure limit 20 ppm (121 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 10 ppm (60 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1 ppm (6.1 mg/m³), JUL2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 10 ppm (60 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 6.1 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 10 ppm (60 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 10 ppm (60 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 10 ppm (60 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 10 ppm (60 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 10 ppm (60 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-tert-BUTYLTOLUENE-air	10H time-weighted average 10 ppm;short term exposure limit 20 ppm	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code 14930; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 2; Total Number of Employees Exposed 187

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health