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Registry of Toxic Effects of Chemical Substances (RTECS)

Toluene, alpha-(2-(2-butoxyethoxy)ethoxy)-4,5-(methylenedioxy)-2-propyl-

RTECS #

XS8050000

CAS #

51-03-6

Updated

December 2013

Molecular Weight

338.49

Molecular Formula

C19H30O5

Synonyms

1,3-Benzodioxole, 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl-
3,4-Methylendioxy-6-propylbenzyl-n-butyl-diaethylenglykolaether (German)
3,4-Methylenedioxy-6-propylbenzyl n-butyl diethyleneglycol ether
5-((2-(2-Butoxyethoxy)ethoxy)methyl)-6-propyl-1,3-benzodioxole
5-Propyl-4-(2,5,8-trioxa-dodecyl)-1,3-benzodioxol (German)
6-(Propylpiperonyl)-butyl carbityl ether
6-Propylpiperonyl butyl diethylene glycol ether
alpha-(2-(2-Butoxyethoxy)ethoxy)-4,5-methylenedioxy-2-propyltoluene
alpha-(2-(2-n-Butoxyethoxy)-ethoxy)-4,5-methylenedioxy-2-propyltoluene
Butacide
Butocide
Butoxide
Butoxide (synergist)
Butyl carbitol 6-propylpiperonyl ether
Butyl-carbityl (6-propylpiperonyl) ether
ENT 14,250
FMC 5273
NCI-C02813
NIA 5273
Nusyn-noxfish
Piperonyl butoxide

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionoral/rat3850 mg/kg/7D-continuousHBPTO* 2,1473,2001
morphological transformoral/rat3600 mg/kg/7D- intermittentMUREAV 575,61,2005
morphological transformembryo/hamster500 µg/LCRNGDP 4,291,1983
mutation in mammalian somatic cellsembryo/human50 µg/LMUREAV 344,27,1995
mutation in mammalian somatic cellslymphocyte/mouse30 mg/LEMMUEG 12,85,1988
sister chromatid exchangeovary/hamster250 µmol/LMUREAV 368,249,1996
specific locus testliver/mouse148 µmol/LMUREAV 608,29,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 200 mg/kg (1D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TXAPA9 23,288,1972
oral/rat 3 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FCTXAV 15,337,1977
oral/rat 2130 mg/kg (11-12D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TIHEEC 11,175,1995
oral/rat 3600 mg/kg (11-12D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTSCDR 19,340,1994
oral/mouse 5 gm/kg (5D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TXAPA9 23,288,1972
oral/mouse 1385 mg/kg (9D pregnant)Reproductive: Effects on newborn: BehavioralTOLED5 71,123,1994
oral/mouse 89600 µg/kg (multigeneration)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
FCTOD7 30,1015,1992
oral/mouse 93.8 gm/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)HBPTO* 2,1465,2001
oral/rat 51.2 gm/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)HBPTO* 2,1466,2001
oral/mouse 1385 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)HBPTO* 2,1467,2001
oral/mouse 1065 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)HBPTO* 2,1467,2001
oral/mouse 3.9 gm/kg (33D male/33D pre-2W after birth)Reproductive: Effects on newborn: BehavioralTIHEEC 25,489,2009
oral/mouse 8 gm/kg (33D male/33D prior to copulation/1-14D pregnant)Reproductive: Effects on newborn: Other postnatal measures or effectsTIHEEC 25,489,2009
oral/mouse 29.3 gm/kg (33D male/33D pre-7D after birth)Reproductive: Effects on newborn: BehavioralTIHEEC 25,489,2009
subcutaneous/mouse 9 gm/kg (6-14D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)
NTIS** PB223-160
subcutaneous/mouse 9 gm/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Eye, ear
NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse toxic dose: 262 gm/kg/1Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
TXCYAC 124,95,1997
oral/mouse lowest published toxic dose: 350.4 gm/kg/1Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
HBPTO* 2,1469,2001
oral/mouse lowest published toxic dose: 263 gm/kg/1Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
ARTODN 68,467,1994
oral/rat lowest published toxic dose: 526 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
FAATDF 22,293,1994
oral/rat lowest published toxic dose: 706.94 gm/kg/96W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
HBPTO* 2,1469,2001
oral/rat lowest published toxic dose: 58.8 gm/kg/7W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens
JTSCDR 33,197,2008
oral/rat lowest published toxic dose: 50400 mg/kg/6W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens
TXAPA9 246,128,2010
subcutaneous/mouse lowest published toxic dose: 1000 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 15000 ppm/20MBlood: Changes in platelet count

Blood: Changes in other cell count (unspecified)
HBPTO* 2,1462,2001
intraperitoneal/mouse lowest published lethal dose: 1 gm/kgTXAPA9 23,288,1972
oral/Dog lethal dose (50 percent kill): 7500 µL/kgAJTMAQ 27,339,1947
oral/mouse lethal dose (50 percent kill): 2600 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Skin and Appendages: Other: Hair
SKEZAP 24,268,1983
oral/rabbit lethal dose (50 percent kill): 2650 mg/kgYKYUA6 32,605,1981
oral/rat lethal dose (50 percent kill): >6 gm/kgENTOX* -,442,2005
skin/rabbit lethal dose (50 percent kill): 200 mg/kgPCOC** -,907,1966
skin/rat lethal dose (50 percent kill): >7950 mg/kgTXAPA9 14,515,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 512 mg/m3/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
HBPTO* 2,1463,2001
oral/Dog lowest published toxic dose: 109 mL/kg/1Y- intermittentLiver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AJTHAB 1,862,1952
oral/Dog lowest published toxic dose: 525 mg/kg/1W- continuousBehavioral: Food intake (animal)HBPTO* 2,1462,2001
oral/Dog lowest published toxic dose: 1400 mg/kg/8W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1462,2001
oral/Dog lowest published toxic dose: 1400 mg/kg/8W- continuousLiver: Change in gall bladder structure or function

Liver: Other changes

Liver: Changes in liver weight
HBPTO* 2,1462,2001
oral/Dog lowest published toxic dose: 2800 mg/kg/8W- continuousLiver: Other changesHBPTO* 2,1462,2001
oral/Dog lowest published toxic dose: 2800 mg/kg/8W- continuousReproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
HBPTO* 2,1462,2001
oral/Dog lowest published toxic dose: 58.4 gm/kg/1Y- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1468,2001
oral/Dog lowest published toxic dose: 116.8 gm/kg/1Y- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHBPTO* 2,1468,2001
oral/Dog lowest published toxic dose: 18.25 gm/kg/1Y- continuousBehavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1468,2001
oral/Dog lowest published toxic dose: 9125 mg/kg/26W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
HBPTO* 2,1468,2001
oral/Dog lowest published toxic dose: 18.25 gm/kg/1Y- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)HBPTO* 2,1468,2001
oral/domestic animal lowest published toxic dose: 12.48 gm/kg/1Y- intermittentLiver: Other changesHBPTO* 2,1469,2001
oral/mouse lowest published toxic dose: 6577.2 mg/kg/3W- continuousBehavioral: Alteration of classical conditioningTIHEEC 25,489,2009
oral/mouse lowest published toxic dose: 9800 mg/kg/4W- continuousBehavioral: Change in psychophysiological testsHBPTO* 2,1465,2001
oral/mouse lowest published toxic dose: 2100 mg/kg/7D- intermittentLiver: Other changes

Liver: Changes in liver weight
FAATDF 38,64,1997
oral/mouse lowest published toxic dose: 4200 mg/kg/6W- intermittentLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FAATDF 38,64,1997
oral/mouse lowest published toxic dose: 116.032 gm/kg/112W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1469,2001
oral/mouse lowest published toxic dose: 116.032 gm/kg/112W- continuousLiver: Other changesHBPTO* 2,1469,2001
oral/mouse lowest published toxic dose: 350.4 gm/kg/1Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1469,2001
oral/mouse lowest published toxic dose: 700.8 gm/kg/1Y- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHBPTO* 2,1469,2001
oral/mouse lowest published toxic dose: 54.6 gm/kg/78W- continuousLiver: Other changes

Liver: Changes in liver weight
HBPTO* 2,1469,2001
oral/mouse lowest published toxic dose: 9000 mg/kg/20D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1463,2001
oral/mouse lowest published toxic dose: 27 gm/kg/20D- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1463,2001
oral/mouse lowest published toxic dose: 27 gm/kg/20D- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
HBPTO* 2,1463,2001
oral/mouse lowest published toxic dose: 27 gm/kg/20D- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
HBPTO* 2,1463,2001
oral/mouse lowest published toxic dose: 90 gm/kg/90D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1463,2001
oral/mouse lowest published toxic dose: 9000 mg/kg/90D- continuousLiver: Other changes

Liver: Changes in liver weight
HBPTO* 2,1463,2001
oral/mouse lowest published toxic dose: 11.56 gm/kg/7W- continuousBehavioral: Change in motor activity (specific assay)HBPTO* 2,1463,2001
oral/rabbit lowest published toxic dose: 1300 mg/kg/13D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1467,2001
oral/rat lowest published toxic dose: 39375 mg/kg/6W- continuousLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 236,61,2007
oral/rat lowest published toxic dose: 4200 mg/kg/42D- continuousLiver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other proteins
HBPTO* 2,1472,2001
oral/rat lowest published toxic dose: 700 mg/kg/7D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)HBPTO* 2,1472,2001
oral/rat lowest published toxic dose: 42 gm/kg/4W- continuousLiver: Other changesHBPTO* 2,1473,2001
oral/rat lowest published toxic dose: 77.7 gm/kg/42D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1473,2001
oral/rat lowest published toxic dose: 44.1 gm/kg/42D- continuousLiver: Other changesHBPTO* 2,1473,2001
oral/rat lowest published toxic dose: 5000 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1467,2001
oral/rat lowest published toxic dose: 3850 mg/kg/7D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FAATDF 38,64,1997
oral/rat lowest published toxic dose: 109 gm/kg/13W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
TXCYAC 72,291,1992
oral/rat lowest published toxic dose: 140 gm/kg/6W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JEPTDQ 4(1),87,1980
oral/rat lowest published toxic dose: 548 gm/kg/2Y- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AJTHAB 1,862,1952
oral/rat lowest published toxic dose: 50.5 mL/kg/31D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1463,2001
oral/rat lowest published toxic dose: 167.13 gm/kg/90D- intermittentLiver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1463,2001
oral/rat lowest published toxic dose: 7000 mg/kg/4W- continuousLiver: Other changes

Liver: Changes in liver weight
HBPTO* 2,1463,2001
oral/rat lowest published toxic dose: 56 gm/kg/4W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
HBPTO* 2,1463,2001
oral/rat lowest published toxic dose: 2.5 mL/kg/3D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHBPTO* 2,1463,2001
oral/rat lowest published toxic dose: 109.2 gm/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1463,2001
oral/rat lowest published toxic dose: 54.6 gm/kg/13W- continuousBlood: Normocytic anemiaHBPTO* 2,1463,2001
oral/rat lowest published toxic dose: 27.3 gm/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
HBPTO* 2,1463,2001
oral/rat lowest published toxic dose: 1500 mg/kg/3D- intermittentKidney, Ureter, and Bladder: IncontinenceHBPTO* 2,1463,2001
oral/rat lowest published toxic dose: 20 gm/kg/10D- intermittentBehavioral: Ataxia

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HBPTO* 2,1463,2001
oral/rat lowest published toxic dose: 595 gm/kg/68W- continuousLiver: Multiple effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1469,2001
oral/rat lowest published toxic dose: 36.5 gm/kg/2Y- continuousLiver: Other changesHBPTO* 2,1469,2001
oral/rat lowest published toxic dose: 182.5 gm/kg/2Y- continuousGastrointestinal: Ulceration or bleeding from large intestineHBPTO* 2,1469,2001
oral/rat lowest published toxic dose: 294.56 gm/kg/40W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHBPTO* 2,1469,2001
oral/rat lowest published toxic dose: 353.47 gm/kg/96W- continuousGastrointestinal: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1469,2001
oral/rat lowest published toxic dose: 353.47 gm/kg/96W- continuousBlood: ThrombocytopeniaHBPTO* 2,1469,2001
skin/rabbit lowest published toxic dose: 4500 mg/kg/3W- intermittentSkin: After topical application: Primary irritationHBPTO* 2,1463,2001

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 30,183,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 30,183,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWENVRAL 7,243,1974
TOXICOLOGY REVIEW85CVA2 5,250,1970
TOXICOLOGY REVIEWTOLED5 142,207,2003
TOXICOLOGY REVIEWBPCEM* 17,237,2003
TOXICOLOGY REVIEWENTOX* -,442,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 659,202,2008
TOXICOLOGY REVIEWMUREAV 674,36,2009
TOXICOLOGY REVIEWMUREAV 682,94,2009
TOXICOLOGY REVIEWFCTOD7 47,1406,2009
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80218; Number of Industries 43; Total Number of Facilities 5234; Number of Occupations 37; Total Number of Employees Exposed 89064; Total Number of Female Employees Exposed 20721
National Occupational Hazard Survey 1974Hazard Code 80218; Number of Industries 46; Total Number of Facilities 5179; Number of Occupations 34; Total Number of Employees Exposed 58709

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-120,1979
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