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Toluene, alpha - (2 - (2 - butoxyethoxy) ethoxy) - 4,5 - (methylenedioxy) - 2 - propyl -

RTECS #: XS8050000

CAS #: 51-03-6


UPDATE: February 2009 MW: 338.49 MF: C19H30O5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,3 - Benzodioxole, 5 - ( (2 - (2 - butoxyethoxy) ethoxy) methyl) - 6 - propyl -
  2. 3,4 - Methylendioxy - 6 - propylbenzyl - n - butyl - diaethylenglykolaether (German)
  3. 3,4 - Methylenedioxy - 6 - propylbenzyl n - butyl diethyleneglycol ether
  4. 5 - ( (2 - (2 - Butoxyethoxy) ethoxy) methyl) - 6 - propyl - 1,3 - benzodioxole
  5. 5 - Propyl - 4 - (2,5,8 - trioxa - dodecyl) - 1,3 - benzodioxol (German)
  6. 6 - (Propylpiperonyl) - butyl carbityl ether
  7. 6 - Propylpiperonyl butyl diethylene glycol ether
  8. Butacide
  9. Butocide
  10. Butoxide
  11. Butoxide (synergist)
  1. Butyl carbitol 6 - propylpiperonyl ether
  2. Butyl - carbityl (6 - propylpiperonyl) ether
  3. ENT 14,250
  4. FMC 5273
  5. NCI - C02813
  6. NIA 5273
  7. Nusyn - noxfish
  8. Piperonyl butoxide
  9. alpha - (2 - (2 - Butoxyethoxy) ethoxy) - 4,5 - methylenedioxy - 2 - propyltoluene
  10. alpha - (2 - (2 - n - Butoxyethoxy) - ethoxy) - 4,5 - methylenedioxy - 2 - propyltoluene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition oral
rat
3,850 mg/kg/7 day- continuous HBPTO* 2,1473,2001
mutation in mammalian somatic cells human embryo 50 g/L MUREAV 344,27,1995
mutation in mammalian somatic cells mouse lymphocyte 30 mg/L EMMUEG 12,85,1988
morphological transform hamster embryo 500 g/L CRNGDP 4,291,1983
morphological transform oral
rat
3,600 mg/kg/7 day- intermittent MUREAV 575,61,2005
sister chromatid exchange hamster ovary 250 mol/L MUREAV 368,249,1996
specific locus test mouse liver 148 mol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg (1 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 23,288,1972
oral
mouse
lowest published toxic dose: 5 gm/kg (5 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 23,288,1972
oral
mouse
lowest published toxic dose: 1,385 mg/kg (9 day pregnant) Reproductive: Effects on newborn: Behavioral TOLED5 71,123,1994
oral
mouse
lowest published toxic dose: 89,600 g/kg (multigeneration) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
FCTOD7 30,1015,1992
oral
mouse
lowest published toxic dose: 93.8 gm/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) HBPTO* 2,1465,2001
oral
mouse
lowest published toxic dose: 1,385 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) HBPTO* 2,1467,2001
oral
mouse
lowest published toxic dose: 1,065 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) HBPTO* 2,1467,2001
oral
rat
lowest published toxic dose: 3 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FCTXAV 15,337,1977
oral
rat
lowest published toxic dose: 2,130 mg/kg (11-12 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TIHEEC 11,175,1995
oral
rat
lowest published toxic dose: 3,600 mg/kg (11-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTSCDR 19,340,1994
oral
rat
lowest published toxic dose: 51.2 gm/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) HBPTO* 2,1466,2001
subcutaneous
mouse
lowest published toxic dose: 9 gm/kg (6-14 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)
NTIS** PB223-160
subcutaneous
mouse
lowest published toxic dose: 9 gm/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Eye, ear
NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 263 gm/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
ARTODN 68,467,1994
oral
mouse
toxic dose : 262 gm/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
TXCYAC 124,95,1997
oral
mouse
lowest published toxic dose: 350.4 gm/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
HBPTO* 2,1469,2001
oral
rat
lowest published toxic dose: 526 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
FAATDF 22,293,1994
oral
rat
lowest published toxic dose: 706.94 gm/kg/96 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
HBPTO* 2,1469,2001
subcutaneous
mouse
lowest published toxic dose: 1,000 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 15,000 ppm/20 minute Blood: Changes in platelet count

Blood: Changes in other cell count (unspecified)
HBPTO* 2,1462,2001
intraperitoneal
mouse
lowest published lethal dose: 1 gm/kg N/R TXAPA9 23,288,1972
oral
dog
lethal dose (50 percent kill): 7,500 L/kg N/R AJTMAQ 27,339,1947
oral
mouse
lethal dose (50 percent kill): 2,600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Skin and Appendages: Other: Hair
SKEZAP 24,268,1983
oral
rat
lethal dose (50 percent kill): >6 gm/kg N/R ENTOX* -,442,2005
oral
rabbit
lethal dose (50 percent kill): 2,650 mg/kg N/R YKYUA6 32,605,1981
skin
rat
lethal dose (50 percent kill): >7,950 mg/kg N/R TXAPA9 14,515,1969
skin
rabbit
lethal dose (50 percent kill): 200 mg/kg N/R PCOC** -,907,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 512 mg/m3/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
HBPTO* 2,1463,2001
oral
dog
lowest published toxic dose: 109 mL/kg/1 year- intermittent Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AJTHAB 1,862,1952
oral
dog
lowest published toxic dose: 525 mg/kg/1 week- continuous Behavioral: Food intake (animal) HBPTO* 2,1462,2001
oral
dog
lowest published toxic dose: 1,400 mg/kg/8 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1462,2001
oral
dog
lowest published toxic dose: 1,400 mg/kg/8 week- continuous Liver: Change in gall bladder structure or function

Liver: Other changes

Liver: Changes in liver weight
HBPTO* 2,1462,2001
oral
dog
lowest published toxic dose: 2,800 mg/kg/8 week- continuous Liver: Other changes HBPTO* 2,1462,2001
oral
dog
lowest published toxic dose: 2,800 mg/kg/8 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
HBPTO* 2,1462,2001
oral
dog
lowest published toxic dose: 58.4 gm/kg/1 year- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1468,2001
oral
dog
lowest published toxic dose: 116.8 gm/kg/1 year- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBPTO* 2,1468,2001
oral
dog
lowest published toxic dose: 18.25 gm/kg/1 year- continuous Behavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1468,2001
oral
dog
lowest published toxic dose: 9,125 mg/kg/26 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
HBPTO* 2,1468,2001
oral
dog
lowest published toxic dose: 18.25 gm/kg/1 year- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) HBPTO* 2,1468,2001
oral
domestic animal
lowest published toxic dose: 12.48 gm/kg/1 year- intermittent Liver: Other changes HBPTO* 2,1469,2001
oral
mouse
lowest published toxic dose: 2,100 mg/kg/7 day- intermittent Liver: Other changes

Liver: Changes in liver weight
FAATDF 38,64,1997
oral
mouse
lowest published toxic dose: 4,200 mg/kg/6 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FAATDF 38,64,1997
oral
mouse
lowest published toxic dose: 9,000 mg/kg/20 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1463,2001
oral
mouse
lowest published toxic dose: 27 gm/kg/20 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1463,2001
oral
mouse
lowest published toxic dose: 27 gm/kg/20 day- continuous Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
HBPTO* 2,1463,2001
oral
mouse
lowest published toxic dose: 27 gm/kg/20 day- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
HBPTO* 2,1463,2001
oral
mouse
lowest published toxic dose: 90 gm/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1463,2001
oral
mouse
lowest published toxic dose: 9,000 mg/kg/90 day- continuous Liver: Other changes

Liver: Changes in liver weight
HBPTO* 2,1463,2001
oral
mouse
lowest published toxic dose: 11.56 gm/kg/7 week- continuous Behavioral: Change in motor activity (specific assay) HBPTO* 2,1463,2001
oral
mouse
lowest published toxic dose: 9,800 mg/kg/4 week- continuous Behavioral: Change in psychophysiological tests HBPTO* 2,1465,2001
oral
mouse
lowest published toxic dose: 116.032 gm/kg/112 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1469,2001
oral
mouse
lowest published toxic dose: 116.032 gm/kg/112 week- continuous Liver: Other changes HBPTO* 2,1469,2001
oral
mouse
lowest published toxic dose: 350.4 gm/kg/1 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1469,2001
oral
mouse
lowest published toxic dose: 700.8 gm/kg/1 year- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBPTO* 2,1469,2001
oral
mouse
lowest published toxic dose: 54.6 gm/kg/78 week- continuous Liver: Other changes

Liver: Changes in liver weight
HBPTO* 2,1469,2001
oral
rat
lowest published toxic dose: 3,850 mg/kg/7 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FAATDF 38,64,1997
oral
rat
lowest published toxic dose: 109 gm/kg/13 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
TXCYAC 72,291,1992
oral
rat
lowest published toxic dose: 140 gm/kg/6 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JEPTDQ 4(1),87,1980
oral
rat
lowest published toxic dose: 548 gm/kg/2 year- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AJTHAB 1,862,1952
oral
rat
lowest published toxic dose: 50.5 mL/kg/31 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1463,2001
oral
rat
lowest published toxic dose: 167.13 gm/kg/90 day- intermittent Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1463,2001
oral
rat
lowest published toxic dose: 7,000 mg/kg/4 week- continuous Liver: Other changes

Liver: Changes in liver weight
HBPTO* 2,1463,2001
oral
rat
lowest published toxic dose: 56 gm/kg/4 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
HBPTO* 2,1463,2001
oral
rat
lowest published toxic dose: 2.5 mL/kg/3 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBPTO* 2,1463,2001
oral
rat
lowest published toxic dose: 109.2 gm/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1463,2001
oral
rat
lowest published toxic dose: 54.6 gm/kg/13 week- continuous Blood: Normocytic anemia HBPTO* 2,1463,2001
oral
rat
lowest published toxic dose: 27.3 gm/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
HBPTO* 2,1463,2001
oral
rat
lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Incontinence HBPTO* 2,1463,2001
oral
rat
lowest published toxic dose: 20 gm/kg/10 day- intermittent Behavioral: Ataxia

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HBPTO* 2,1463,2001
oral
rat
lowest published toxic dose: 5,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1467,2001
oral
rat
lowest published toxic dose: 595 gm/kg/68 week- continuous Liver: Multiple effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1469,2001
oral
rat
lowest published toxic dose: 36.5 gm/kg/2 year- continuous Liver: Other changes HBPTO* 2,1469,2001
oral
rat
lowest published toxic dose: 182.5 gm/kg/2 year- continuous Gastrointestinal: Ulceration or bleeding from large intestine HBPTO* 2,1469,2001
oral
rat
lowest published toxic dose: 294.56 gm/kg/40 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBPTO* 2,1469,2001
oral
rat
lowest published toxic dose: 353.47 gm/kg/96 week- continuous Gastrointestinal: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1469,2001
oral
rat
lowest published toxic dose: 353.47 gm/kg/96 week- continuous Blood: Thrombocytopenia HBPTO* 2,1469,2001
oral
rat
lowest published toxic dose: 4,200 mg/kg/42 day- continuous Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other proteins
HBPTO* 2,1472,2001
oral
rat
lowest published toxic dose: 700 mg/kg/7 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) HBPTO* 2,1472,2001
oral
rat
lowest published toxic dose: 42 gm/kg/4 week- continuous Liver: Other changes HBPTO* 2,1473,2001
oral
rat
lowest published toxic dose: 77.7 gm/kg/42 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1473,2001
oral
rat
lowest published toxic dose: 44.1 gm/kg/42 day- continuous Liver: Other changes HBPTO* 2,1473,2001
oral
rat
lowest published toxic dose: 39,375 mg/kg/6 week- continuous Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 236,61,2007
oral
rabbit
lowest published toxic dose: 1,300 mg/kg/13 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1467,2001
skin
rabbit
lowest published toxic dose: 4,500 mg/kg/3 week- intermittent Skin: After topical application: Primary irritation HBPTO* 2,1463,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,183,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,183,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
ENVRAL 7,243,1974
TOXICOLOGY REVIEW
85CVA2 5,250,1970
TOXICOLOGY REVIEW
TOLED5 142,207,2003
TOXICOLOGY REVIEW
BPCEM* 17,237,2003
TOXICOLOGY REVIEW
ENTOX* -,442,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
MUREAV 659,202,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80218;
Number of Industries 46;
Total Number of Facilities 5,179;
Number of Occupations 34;
Total Number of Employees Exposed 58,709
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80218;
Number of Industries 43;
Total Number of Facilities 5,234;
Number of Occupations 37;
Total Number of Employees Exposed 89,064;
Total Number of Female Employees Exposed 20,721


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a synergist for pyrethrins and related insecticides
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-120,1979


REFERENCES:

CODEN
REFERENCE

85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
AJTHAB American Journal of Tropical Medicine and Hygiene. (Allen Press, 1041 New Hampshire St., Lawrence, KS 66044) V.1- 1952-
AJTMAQ American Journal of Tropical Medicine. (Baltimore, MD) V.1-31, 1921-51. For publisher information, see AJTHAB.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as a synergist for pyrethrins and related insecticides

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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