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Tin fluoride

RTECS #: XQ3450000

CAS #: 7783-47-3


UPDATE: May 2009 MW: 156.69 MF: F2Sn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Fluoristan
  2. Stannous fluoride
  1. Tin bifluoride
  2. Tin difluoride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 6 µmol/plate (-enzymatic activation step) MUREAV 90,91,1981
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
15 pph/24 hour FLUOA4 6,113,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 16,150 µg/kg N/R DZZEA7 34,484,1979
oral
mouse
lethal dose (50 percent kill): 184 mg/kg N/R OYYAA2 2,411,1968
oral
rat
lethal dose (50 percent kill): 360 mg/kg Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555162


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 392 mg/kg/10 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOLED5 7,463,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2.5 mg(F)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg(Sn)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 27,237,1982
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 27,237,1982
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,208,1987
TOXICOLOGY REVIEW
HBTME* ,839,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 mg(Sn)/m3 DTLVS* 3,257,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(F)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 2.5 mg(F)/m3, FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 2.5 mg(F)/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 1 mg(F)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 2 mg(Sn)/m3, short term exposure limit 8 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit - HUNGARY time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 2 mg(Sn)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 mg(Sn)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.6 mg(F)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit - POLAND time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.2 mg/m3, short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 2 mg(F)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg(F)/m3,KZG- week 4 mg(F)/m3, Skin, DEC2006
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg(Sn)/m3,KZG- week 4 mg(Sn)/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - THAILAND time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUORIDES, INORGANIC-air 10 hour time-weighted average 2.5 mg(F)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 69735;
Number of Industries 2;
Total Number of Facilities 40;
Number of Occupations 3;
Total Number of Employees Exposed 79
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 69735;
Number of Industries 1;
Total Number of Facilities 146;
Number of Occupations 2;
Total Number of Employees Exposed 340;
Total Number of Female Employees Exposed 257


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in caries prophylactic
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag, Postfach 860420, D-8000 Munich 86, Fed. Rep. Ger.) V.1- 1946-
FLUOA4 Fluoride. (International Soc. for Fluoride Research, Inc., POB 692, Warren, MI 48090) V.3- 1970-
HBTME*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used in caries prophylactic

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen

Click Here for Additional Information about RTECS

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