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Tin (II) chloride, dihydrate (1:2:2)

RTECS #: XP8850000

CAS #: 10025-69-1


UPDATE: May 2009 MW: 225.63 MF: Cl2Sn•2H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. REFERENCES:

SYNONYMS:

  1. Stannochlor
  2. Stannous dichloride dihydrate
  1. Stannous chloride dihydrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage hamster ovary 50 µmol/L MUREAV 119,195,1983
DNA damage human leukocyte 10 µmol/L CBINA8 46,189,1983
DNA damage human Ascites tumor 55.4 µmol/L/24 hour FCTOD7 40,1493,2002
other mutation test systems Escherichia coli 2 mmol/L MUREAV 189,263,1987
phage inhibition capacity Escherichia coli 10 mg/L FCTOD7 32,477,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 3 gm/kg (7-12 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
CHYCDW 24,19,1990
oral
rat
lowest published toxic dose: 3 gm/kg (7-12 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) CHYCDW 24,19,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lethal dose (50 percent kill): 258.4 mg/kg N/R VCVN1* -,407,1988
intraperitoneal
rat
lowest published toxic dose: 44.4 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) VCVN1* -,407,1988
intravenous
dog
lowest published lethal dose: 20 mg/kg N/R HBTXAC 1,282,1955
intravenous
rat
lethal dose (50 percent kill): 7,830 µg/kg N/R APYPAY 32,193,1981
oral
human
lowest published toxic dose: 161 mg(St)/kg Brain and Coverings: Other degenerative changes

Gastrointestinal: Other changes
FCTOD7 41,1663,2003
oral
rat
lethal dose (50 percent kill): 2,274.6 mg/kg N/R VCVN1* -,407,1988
subcutaneous
rat
lowest published toxic dose: 5.6 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Kidney, Ureter, and Bladder: Other changes
VCVN1* -,408,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 113 mg/kg/3 day- intermittent Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in humoral immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 21,279,1984
intraperitoneal
mouse
lowest published toxic dose: 11,281 µg/kg/5 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
INHEAO 27,131,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg(Sn)/m3 DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 mg(Sn)/m3 DTLVS* 3,257,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit - FINLAND time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 2 mg(Sn)/m3, short term exposure limit 8 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 2 mg(Sn)/m3, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 mg(Sn)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg(Sn)/m3,KZG- week 4 mg(Sn)/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 mg(Sn)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 mg(Sn)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9955;
Number of Industries 3;
Total Number of Facilities 260;
Number of Occupations 7;
Total Number of Employees Exposed 1,664;
Total Number of Female Employees Exposed 680


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

N/R


REFERENCES:

CODEN
REFERENCE

APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90.
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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