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Registry of Toxic Effects of Chemical Substances (RTECS)

Tin(II) chloride, dihydrate (1:2:2)

RTECS #

XP8850000

CAS #

10025-69-1

Updated

September 201

Molecular Weight

225.63

Molecular Formula

Cl2Sn·2H2O

Synonyms

Stannochlor
Stannous chloride dihydrate
Stannous dichloride dihydrate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageleukocyte/human10 µmol/LCBINA8 46,189,1983
DNA Damageovary/hamster50 µmol/LMUREAV 119,195,1983
DNA DamageAscites tumor/human55.4 µmol/L/24HFCTOD7 40,1493,2002
other mutation test systems/Escherichia coli2 mmol/LMUREAV 189,263,1987
phage inhibition capacity/Escherichia coli10 mg/LFCTOD7 32,477,1994

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 3 gm/kg (7-12D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
CHYCDW 24,19,1990
oral/rat 3 gm/kg (7-12D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)CHYCDW 24,19,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 258.4 mg/kgVCVN1* -,407,1988
intraperitoneal/rat lowest published toxic dose: 44.4 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)VCVN1* -,407,1988
intravenous/Dog lowest published lethal dose: 20 mg/kgHBTXAC 1,282,1955
intravenous/rat lethal dose (50 percent kill): 7830 µg/kgAPYPAY 32,193,1981
oral/human lowest published toxic dose: 161 mg(St)/kgBrain and Coverings: Other degenerative changes

Gastrointestinal: Other changes
FCTOD7 41,1663,2003
oral/rat lethal dose (50 percent kill): 2274.6 mg/kgVCVN1* -,407,1988
subcutaneous/rat lowest published toxic dose: 5.6 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Kidney, Ureter, and Bladder: Other changes
VCVN1* -,408,1988
Tank with water/Limanda lethal concentration (50 percent kill): >0.035 mg/L/24HAQUTO* 7,135,1985
Tank with water/Limanda lethal concentration (50 percent kill): >0.035 mg/L/48HAQUTO* 7,135,1985
Tank with water/Limanda lethal concentration (50 percent kill): >0.035 mg/L/72HAQUTO* 7,135,1985
Tank with water/Limanda lethal concentration (50 percent kill): >0.035 mg/L/96HAQUTO* 7,135,1985

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 113 mg/kg/3D- intermittentEndocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in humoral immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 21,279,1984
intraperitoneal/mouse lowest published toxic dose: 11281 µg/kg/5D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
INHEAO 27,131,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 mg(Sn)/m3DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 2 mg(Sn)/m3DTLVS* 3,257,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit-HUNGARYtime-weighted average 2 mg(Sn)/m3, short term exposure limit 8 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit-KOREAtime-weighted average 2 mg(Sn)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 mg(Sn)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg(Sn)/m3, KZG-week 4 mg(Sn)/m3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2 mg(Sn)/m3;short term exposure limit 4 mg(Sn)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 2 mg(Sn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 2 mg(Sn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 2 mg(Sn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 2 mg(Sn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X9955; Number of Industries 3; Total Number of Facilities 260; Number of Occupations 7; Total Number of Employees Exposed 1664; Total Number of Female Employees Exposed 680
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