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Registry of Toxic Effects of Chemical Substances (RTECS)

Tin(IV) chloride (1:4)

RTECS #

XP8750000

CAS #

7646-78-8

Updated

September 201

Molecular Weight

260.49

Molecular Formula

Cl4Sn

Synonyms

Etain (tetrachlorure d') (French)
Libavius fuming spirit
Stagno (tetracloruro di) (Italian)
Stannane, tetrachloro-
Stannic chloride
Tin chloride
Tin perchloride
Tin tetrachloride
Tintetrachloride (Dutch)
Zinntetrachlorid (German)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 5%/48HCODEDG 29,110,1993

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human4 mg/LCYTBAI 56,23,1988

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 365 gm/kg/1Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,839,2007

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Non-mammalian species, liver tumor Inhibitor Concentration (50 percent kill): >10 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.AQUTO* 32,143,1995
In Vitro/Non-mammalian species, liver tumor Inhibitor Concentration (50 percent kill): >10 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.AQUTO* 32,143,1995
inhalation/rat lethal concentration (50 percent kill): 2300 mg/m3/10MTOXID9 1,77,1981
intraperitoneal/mouse lethal dose (50 percent kill): 99 mg/kgTXAPA9 63,461,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 166 mg/kg/4W- intermittentAutonomic Nervous System: SympathomimeticPJPPAA 41,7,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 mg(Sn)/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWHBTME* ,839,2007
TOXICOLOGY REVIEWHUTOX* -,515,1996

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 2 mg(Sn)/m3DTLVS* 3,257,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit-HUNGARYtime-weighted average 2 mg(Sn)/m3, short term exposure limit 8 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit-KOREAtime-weighted average 2 mg(Sn)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 mg(Sn)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit-POLANDtime-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg(Sn)/m3, KZG-week 4 mg(Sn)/m3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2 mg(Sn)/m3;short term exposure limit 4 mg(Sn)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 2 mg(Sn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 2 mg(Sn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 2 mg(Sn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 2 mg(Sn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80077; Number of Industries 5; Total Number of Facilities 201; Number of Occupations 16; Total Number of Employees Exposed 7310; Total Number of Female Employees Exposed 4836
National Occupational Hazard Survey 1974Hazard Code 80077; Number of Industries 11; Total Number of Facilities 408; Number of Occupations 18; Total Number of Employees Exposed 2399

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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