Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Tin(II) chloride (1:2)

RTECS #

XP8700000

CAS #

7772-99-8

Updated

September 201

Molecular Weight

189.59

Molecular Formula

Cl2Sn

Synonyms

C.I. 77864
Dichlorotin
NCI-C02722
Stannous chloride
Stannous dichloride
Tin dichloride
Uniston CR-HT 200

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/mouse150 mg/kgEMMUEG 25,302,1995
Cytogenetic Analysisovary/hamster25 mg/LSCIEAS 236,933,1987
Cytogenetic Analysisovary/hamster132 µmol/LMUREAV 608,28,2006
Cytogenetic Analysis/hamster132 µmol/LMUREAV 608,28,2006
mutation in microorganisms/Salmonella typhimurium5000 µmol/L/20MMUREAV 583,146,2005
mutation in microorganisms/Escherichia coli1250 µmol/L/20MMUREAV 583,146,2005
mutation in microorganisms/Saccharomyes cerevisiae25 mmol/L/40MMUREAV 583,146,2005
other mutation test systems/Escherichia coli150 nmol/tubeLAMEDS 6,252,1986
phage inhibition capacity/Escherichia coli50 µg/wellMUREAV 260,349,1991
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae6 mmol/LMUTAEX 1,21,1986
sister chromatid exchangeovary/hamster25 mg/LSCIEAS 236,933,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 15167 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964
oral/rat 300 mg/kg (7-15D pregnant)Reproductive: Other effects to embryo or fetusNEZAAQ 48,247,1993

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 176.4 gm/kg/105W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,839,2007
oral/rat lowest published toxic dose: 44100 mg/kg/105W- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors
NTIS** PB82-242553
oral/rat lowest published toxic dose: 73500 mg/kg/105W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease
NTIS** PB82-242553

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 65598 µg/kgCOREAF 256,1043,1963
intraperitoneal/rat lethal dose (50 percent kill): 316 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous/Dog lowest published lethal dose: 20 mg/kgHBAMAK 4,1420,1935
intravenous/mouse lethal dose (50 percent kill): 17800 µg/kgCSLNX* NX#02202
intravenous/rat lethal dose (50 percent kill): 17 mg/kgUSXXAM #5015462
oral/cat lowest published toxic dose: 45 mg/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
HBTME* -,839,2007
oral/Dog lowest published lethal dose: 500 mg/kgHBAMAK 4,1420,1935
oral/guinea pig lowest published lethal dose: 60 mg/kgFAONAU 50A,101,1972
oral/mouse lethal dose (50 percent kill): 250 mg/kgFAONAU 50A,101,1972
oral/rabbit lethal dose (50 percent kill): 10 gm/kgFAONAU 48A,75,1970
oral/rat lethal dose (50 percent kill): 700 mg/kgFOREAE 7,313,1942
subcutaneous/Dog lowest published lethal dose: 159 mg/kgEQSSDX 1,1,1975
subcutaneous/guinea pig lowest published lethal dose: 400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Nutritional and Gross Metabolic: Body temperature increase
BMJOAE 2,217,1913
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 215 mg/kgGISAAA 55(12),17,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 3 mg/m3/24H/5W- continuousBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
GISAAA 55(12),17,1990
intramuscular/guinea pig lowest published toxic dose: 240 mg/kg/6D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldCOREAF 243,2178,1956
intramuscular/mouse lowest published toxic dose: 360 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldCOREAF 243,2178,1956
intramuscular/rabbit lowest published toxic dose: 240 mg/kg/6D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldCOREAF 243,2178,1956
oral/mouse lowest published toxic dose: 328 gm/kg/13W- continuousGastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-231,1982
oral/rabbit lowest published toxic dose: 840 mg/kg/12W- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Impotence

Reproductive: Other effects on male
TXCYAC 207,81,2005
oral/rabbit lowest published toxic dose: 840 mg/kg/12W- intermittentEndocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 235,194,2007
oral/rat lowest published toxic dose: 882 mg/kg/1260D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHBTME* -,839,2007
oral/rat lowest published toxic dose: 6300 mg/kg/4W- continuousBehavioral: Food intake (animal)

Gastrointestinal: Changes in structure or function of exocrine pancreas

Blood: Changes in cell count (unspecified)
VCVN1* -,408,1988
oral/rat lowest published toxic dose: 16800 mg/kg/4W- continuousBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVN1* -,410,1988
oral/rat lowest published toxic dose: 14000 mg/kg/4W- continuousBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes
VCVN1* -,410,1988
oral/rat lowest published toxic dose: 8051 mg/kg/4W- continuousBlood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Fe
38MKAJ 2A,1946,1981
oral/rat lowest published toxic dose: 190 mg/kg/90D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Changes in: Ca
TOLED5 9,207,1981
oral/rat lowest published toxic dose: 540 mg/kg/90D- intermittentLiver: Other changes

Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TXCYAC 16,267,1980
oral/rat lowest published toxic dose: 95841 µg/kg/3D- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Musculoskeletal: Other changes
TOLED5 5,275,1980
unreported route/rat lowest published toxic dose: 800 mg/kg/4W- intermittentCardiac: Cardiomyopathy including infarction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides
HBTME* -,839,2007

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 mg(Sn)/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 544,179,2003
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHBTME* ,839,2007
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 2 mg(Sn)/m3DTLVS* 3,257,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit-HUNGARYtime-weighted average 2 mg(Sn)/m3, short term exposure limit 8 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit-KOREAtime-weighted average 2 mg(Sn)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 mg(Sn)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit-POLANDtime-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg(Sn)/m3, KZG-week 4 mg(Sn)/m3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2 mg(Sn)/m3;short term exposure limit 4 mg(Sn)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 2 mg(Sn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 2 mg(Sn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 2 mg(Sn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 2 mg(Sn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X8590; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 645; Total Number of Female Employees Exposed 645
National Occupational Exposure Survey 1983Hazard Code 69730; Number of Industries 49; Total Number of Facilities 2435; Number of Occupations 40; Total Number of Employees Exposed 43253; Total Number of Female Employees Exposed 15296
National Occupational Hazard Survey 1974Hazard Code 69730; Number of Industries 69; Total Number of Facilities 4037; Number of Occupations 43; Total Number of Employees Exposed 50592

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
NCI Carcinogenesis Studies (feed);no evidence:mouse
TOP