CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Thiosulfuric acid, disodium salt

RTECS #: XN6476000

CAS #: 7772-98-7

UPDATE: February 2006 MW: 158.10 MF: O3S2•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Chlorine Control
  2. Chlorine Cure
  3. Declor - It
  4. Disodium thiosulfate
  5. S - Hydril
  6. Sodium hyposulfite
  1. Sodium oxide sulfide (Na2S2O3)
  2. Sodium thiosulfate
  3. Sodium thiosulfate anhydrous
  4. Sodium thiosulphate (Na2S2O3)
  5. Sodothiol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intravenous
rat 		1,500 mg/kg VOONC* -,1132,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 5,200 mg/kg N/R NYKZAU 53,404,1957
intravenous
dog 		lethal dose (50 percent kill): 3 gm/kg Nutritional and Gross Metabolic: Changes in: Na FEREAC 68,66416,2003
intravenous
mouse 		lethal dose (50 percent kill): 1.19 gm/kg Nutritional and Gross Metabolic: Changes in: Na FEREAC 68,66416,2003
intravenous
rat 		lethal dose : >2,500 mg/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 25,297,1925
intravenous
rat 		lethal dose (50 percent kill): >2,500 mg/kg Nutritional and Gross Metabolic: Changes in: Na FEREAC 68,66416,2003
oral
rat 		lethal dose (50 percent kill): >5,000 mg/kg N/R FEREAC 68,66416,2003
subcutaneous
frog 		lowest published lethal dose: 6 gm/kg N/R AIPTAK 5,161,1899
subcutaneous
rabbit 		lowest published lethal dose: 4 gm/kg N/R AIPTAK 5,161,1899
unreported route
mouse 		lowest published toxic dose: 800 mg/kg Immunological Including Allergic: Decreased immune response EKFAE9 61,56,1998
unreported route
rat 		lowest published toxic dose: 800 mg/kg Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		EKFAE9 61,56,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80153;
Number of Industries 107;
Total Number of Facilities 11,199;
Number of Occupations 62;
Total Number of Employees Exposed 61,158
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80153;
Number of Industries 118;
Total Number of Facilities 13,359;
Number of Occupations 89;
Total Number of Employees Exposed 143,967;
Total Number of Female Employees Exposed 55,082


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as complexing agent for SILVER in photographic fixing bath, solar heat storage material
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
VOONC* Voprosi oncologii (Questions of oncology. Journal of Petrov's Institute of Oncology, B. Zelenina str, 43a, Spb 197110, Russia) V.1- 1955-

Used as complexing agent for SILVER in photographic fixing bath, solar heat storage material

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us