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Registry of Toxic Effects of Chemical Substances (RTECS)

Thiophene

RTECS #

XM7350000

CAS #

110-02-1

Updated

February 2006

Molecular Weight

84.14

Molecular Formula

C4H4S

Synonyms

CP 34
Divinylene sulfide
Huile H50
Huile HSO
Thiacyclopentadiene
Thiaphene
Thiofen (Czech)
Thiofuram
Thiofuran
Thiofurfuran
Thiole
Thiophen
Thiotetrole
USAF EK-1860

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 9500 mg/m3/2HGTPZAB 10(2),57,1966
inhalation/rat Lowest published lethal concentration: 2000 ppm/6HTOXID9 8,141,1988
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgNTIS** AD277-689
oral/mouse lethal dose (50 percent kill): 420 mg/kgGTPZAB 10(2),57,1966
oral/rat lethal dose (50 percent kill): 1400 mg/kgGTPZAB 10(2),57,1966
skin/guinea pig lethal dose (50 percent kill): >20 mL/kgNTIS** OTS0555960
subcutaneous/rabbit lethal dose (50 percent kill): 830 mg/kg85JCAE -,1089,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 1010 mg/m3/6H/21W- intermittentLiver: Liver function tests impaired

Endocrine: Evidence of thyroid hyperfunction
GTPZAB 10(2),57,1966
inhalation/rabbit lowest published toxic concentration: 1010 mg/m3/6H/21W- intermittentLiver: Liver function tests impaired

Endocrine: Evidence of thyroid hyperfunction
GTPZAB 10(2),57,1966
inhalation/rat lowest published toxic concentration: 3 mg/m3/24H/80D- continuousBehavioral: Muscle contraction or spasticity

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Endocrine: Other changes
GISAAA 32(6),3,1967
inhalation/rat lowest published toxic concentration: 1010 mg/m3/6H/21W- intermittentLiver: Liver function tests impaired

Endocrine: Evidence of thyroid hyperfunction
GTPZAB 10(2),57,1966
inhalation/rat lowest published toxic concentration: 1600 ppm/6H/15D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555960
oral/rat lowest published toxic dose: 9500 mg/kg/19D- intermittentBehavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555960

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWATORAI -,-,1948

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 20 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8861
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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