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Registry of Toxic Effects of Chemical Substances (RTECS)

Thiocyanic acid, sodium salt

RTECS #

XL2275000

CAS #

540-72-7

Updated

July 2013

Molecular Weight

81.07

Molecular Formula

CNS·Na

Synonyms

Haimased
Natriumrhodanid (German)
Scyan
Sodium isothiocyanate
Sodium rhodanate
Sodium rhodanide
Sodium sulfocyanate
Sodium sulfocyanide
Sodium thiocyanate
Sodium thiocyanide
Thiocyanate sodium
Thiocyanic acid, sodium salt, ground
USAF EK-T-434

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/guinea pig lowest published lethal dose: 500 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
AEPPAE 169,429,1933
intraperitoneal/mouse lethal dose (50 percent kill): 500 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
JJPAAZ 3,99,1954
intraperitoneal/rat lethal dose (50 percent kill): 540 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
JPETAB 96,416,1949
intratracheal/rat lethal dose (50 percent kill): 232 mg/kg85GMAT -,106,1982
intravenous/Dog lowest published lethal dose: 100 mg/kgGastrointestinal: Nausea or vomitingAEPPAE 169,429,1933
intravenous/mouse lethal dose (50 percent kill): 484 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
intravenous/rabbit lowest published lethal dose: 100 mg/kgAEPPAE 169,429,1933
oral/domestic animal lethal dose (50 percent kill): 520 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral/guinea pig lowest published lethal dose: 600 mg/kgJAPMA8 29,152,1940
oral/mouse lethal dose (50 percent kill): 809 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral/mouse lethal dose (50 percent kill): 362 mg/kg85GMAT -,106,1982
oral/mouse lethal dose (50 percent kill): 360 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral/rabbit lowest published lethal dose: 750 mg/kgAEPPAE 169,429,1933
oral/rat lethal dose (50 percent kill): 764 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
oral/rat lethal dose (50 percent kill): 837 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral/rat lethal dose (50 percent kill): 1180 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral/rat lethal dose (50 percent kill): 232 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
subcutaneous/guinea pig lowest published lethal dose: 500 mg/kgJAPMA8 29,152,1940
subcutaneous/mouse lowest published lethal dose: 400 mg/kgJAPMA8 29,152,1940
subcutaneous/rabbit lowest published lethal dose: 200 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Food intake (animal)
AEPPAE 152,250,1930

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 612 mg/kg/23D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPMA8 29,152,1940
oral/mouse lowest published toxic dose: 490 mg/kg/7W- continuousEndocrine: Changes in thyroid weightECJPAE 32,635,1985

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 2 mg(CN)/m3, inhal, skin, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84443; Number of Industries 26; Total Number of Facilities 1116; Number of Occupations 25; Total Number of Employees Exposed 28328; Total Number of Female Employees Exposed 6415
National Occupational Hazard Survey 1974Hazard Code 84443; Number of Industries 28; Total Number of Facilities 5091; Number of Occupations 31; Total Number of Employees Exposed 28357

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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