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Thiocyanic acid, sodium salt

RTECS #: XL2275000

CAS #: 540-72-7


UPDATE: February 2006 MW: 81.07 MF: CNS•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Haimased
  2. Natriumrhodanid (German)
  3. Scyan
  4. Sodium thiocyanate
  5. Sodium thiocyanide
  6. Sodium isothiocyanate
  7. Sodium rhodanate
  1. Sodium rhodanide
  2. Sodium sulfocyanate
  3. Sodium sulfocyanide
  4. Thiocyanate sodium
  5. Thiocyanic acid, sodium salt, ground
  6. USAF EK - T - 434


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
guinea pig
lowest published lethal dose: 500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
AEPPAE 169,429,1933
intraperitoneal
mouse
lethal dose (50 percent kill): 500 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
JJPAAZ 3,99,1954
intraperitoneal
rat
lethal dose (50 percent kill): 540 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
JPETAB 96,416,1949
intratracheal
rat
lethal dose (50 percent kill): 232 mg/kg N/R 85GMAT -,106,1982
intravenous
dog
lowest published lethal dose: 100 mg/kg Gastrointestinal: Nausea or vomiting AEPPAE 169,429,1933
intravenous
mouse
lethal dose (50 percent kill): 484 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
intravenous
rabbit
lowest published lethal dose: 100 mg/kg N/R AEPPAE 169,429,1933
oral
domestic animal
lethal dose (50 percent kill): 520 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral
guinea pig
lowest published lethal dose: 600 mg/kg N/R JAPMA8 29,152,1940
oral
mouse
lethal dose (50 percent kill): 362 mg/kg N/R 85GMAT -,106,1982
oral
mouse
lethal dose (50 percent kill): 360 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral
mouse
lethal dose (50 percent kill): 809 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral
rat
lethal dose (50 percent kill): 764 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
oral
rat
lethal dose (50 percent kill): 1,180 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral
rat
lethal dose (50 percent kill): 232 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral
rat
lethal dose (50 percent kill): 837 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral
rabbit
lowest published lethal dose: 750 mg/kg N/R AEPPAE 169,429,1933
subcutaneous
guinea pig
lowest published lethal dose: 500 mg/kg N/R JAPMA8 29,152,1940
subcutaneous
mouse
lowest published lethal dose: 400 mg/kg N/R JAPMA8 29,152,1940
subcutaneous
rabbit
lowest published lethal dose: 200 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Food intake (animal)
AEPPAE 152,250,1930


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 612 mg/kg/23 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPMA8 29,152,1940
oral
mouse
lowest published toxic dose: 490 mg/kg/7 week- continuous Endocrine: Changes in thyroid weight ECJPAE 32,635,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84443;
Number of Industries 28;
Total Number of Facilities 5,091;
Number of Occupations 31;
Total Number of Employees Exposed 28,357
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84443;
Number of Industries 26;
Total Number of Facilities 1,116;
Number of Occupations 25;
Total Number of Employees Exposed 28,328;
Total Number of Female Employees Exposed 6,415


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical, pharmaceutical and veterinary drug
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as an industrial chemical, pharmaceutical and veterinary drug

RTECS Compound Description:
   Agricultural Chemical
   Drug

Click Here for Additional Information about RTECS

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