CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Thiocyanic acid, potassium salt

RTECS #: XL1925000

CAS #: 333-20-0


UPDATE: August 2007 MW: 97.18 MF: CNSK


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Arterocyn
  2. Aterocyn
  3. Kyonate
  4. Potassium isothiocyanate
  5. Potassium rhodanate
  6. Potassium sulfocyanate
  1. Potassium thiocyanate
  2. Potassium thiocyanide
  3. Rhocya
  4. Rodanca
  5. Thio - cara


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
domestic animal
lowest published toxic dose: 1,779 mg/kg (1-20 week pregnant) Reproductive: Specific developmental abnormalities: Endocrine system RJARAV 14,67,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
frog
lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1391,1935
intramuscular
pigeon
lowest published lethal dose: 750 mg/kg N/R HBAMAK 4,1391,1935
intraperitoneal
mouse
lethal dose (50 percent kill): 600 mg/kg N/R BJPCAL 4,1,1949
intravenous
dog
lowest published lethal dose: 100 mg/kg N/R JAPMA8 29,152,1940
intravenous
mouse
lethal dose (50 percent kill): 88,200 g/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
intravenous
rabbit
lowest published lethal dose: 150 mg/kg N/R HBAMAK 4,1391,1935
oral
frog
lowest published lethal dose: 300 mg/kg N/R HBAMAK 4,1391,1935
oral
guinea pig
lowest published lethal dose: 600 mg/kg N/R JAPMA8 29,152,1940
oral
human
lowest published lethal dose: 80 mg/kg Behavioral: Hallucinations, distorted perceptions

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
JAMAAP 119,1177,1942
oral
human
lowest published toxic dose: 428.6 mg/kg Behavioral: Toxic psychosis

Behavioral: Hallucinations, distorted perceptions

Gastrointestinal: Gastritis
VCVN1* -,354,1988
oral
man
lowest published toxic dose: 428 mg/kg Behavioral: Hallucinations, distorted perceptions

Behavioral: Toxic psychosis

Gastrointestinal: Ulceration or bleeding from stomach
ATXKA8 23,66,1967
oral
mouse
lethal dose (50 percent kill): 594 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
oral
mouse
lethal dose (50 percent kill): 590 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral
rat
lethal dose (50 percent kill): 854 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
oral
rabbit
lowest published lethal dose: 500 mg/kg N/R HBAMAK 4,1391,1935
subcutaneous
guinea pig
lowest published lethal dose: 150 mg/kg N/R HBAMAK 4,1391,1935
subcutaneous
pigeon
lowest published lethal dose: 500 mg/kg N/R HBAMAK 4,1391,1935
subcutaneous
rat
lowest published lethal dose: 1 gm/kg N/R JAPMA8 29,152,1940
subcutaneous
rabbit
lowest published lethal dose: 550 mg/kg N/R HBAMAK 4,1391,1935
unreported route
frog
lowest published lethal dose: 250 mg/kg N/R JAPMA8 29,152,1940


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 600 mg/kg/22 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPMA8 29,152,1940
oral
rat
lowest published toxic dose: 47,040 mg/kg/50 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Endocrine: Changes in thyroid weight

Blood: Other changes
JTEHD6 5,579,1979


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
EJIME* 17,529,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 60570;
Number of Industries 18;
Total Number of Facilities 466;
Number of Occupations 15;
Total Number of Employees Exposed 3,959
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 60570;
Number of Industries 18;
Total Number of Facilities 758;
Number of Occupations 16;
Total Number of Employees Exposed 17,270;
Total Number of Female Employees Exposed 3,224


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
EJIME* European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
RJARAV Rhodesian Journal of Agricultural Research. (Salisbury, Rhodesia) V.1-17, 1963-79.
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as a hypotensive agent

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us