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Registry of Toxic Effects of Chemical Substances (RTECS)

Thiocyanic acid, potassium salt

RTECS #

XL1925000

CAS #

333-20-0

Updated

July 2013

Molecular Weight

97.18

Molecular Formula

CNS·K

Synonyms

Arterocyn
Aterocyn
Kyonate
Potassium isothiocyanate
Potassium rhodanate
Potassium sulfocyanate
Potassium thiocyanate
Potassium thiocyanide
Rhocya
Rodanca
Thio-cara

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/domestic animal 1779 mg/kg (1-20W pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemRJARAV 14,67,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intramuscular/frog lowest published lethal dose: 100 mg/kgHBAMAK 4,1391,1935
intramuscular/pigeon lowest published lethal dose: 750 mg/kgHBAMAK 4,1391,1935
intraperitoneal/mouse lethal dose (50 percent kill): 600 mg/kgBJPCAL 4,1,1949
intravenous/Dog lowest published lethal dose: 100 mg/kgJAPMA8 29,152,1940
intravenous/mouse lethal dose (50 percent kill): 88200 µg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
intravenous/rabbit lowest published lethal dose: 150 mg/kgHBAMAK 4,1391,1935
oral/frog lowest published lethal dose: 300 mg/kgHBAMAK 4,1391,1935
oral/guinea pig lowest published lethal dose: 600 mg/kgJAPMA8 29,152,1940
oral/human lowest published lethal dose: 80 mg/kgBehavioral: Hallucinations, distorted perceptions

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
JAMAAP 119,1177,1942
oral/human lowest published toxic dose: 428.6 mg/kgBehavioral: Toxic psychosis

Behavioral: Hallucinations, distorted perceptions

Gastrointestinal: Gastritis
VCVN1* -,354,1988
oral/man lowest published toxic dose: 428 mg/kgBehavioral: Hallucinations, distorted perceptions

Behavioral: Toxic psychosis

Gastrointestinal: Ulceration or bleeding from stomach
ATXKA8 23,66,1967
oral/mouse lethal dose (50 percent kill): 594 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
oral/mouse lethal dose (50 percent kill): 590 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Behavioral: Tetany
VCVN1* -,353,1988
oral/rabbit lowest published lethal dose: 500 mg/kgHBAMAK 4,1391,1935
oral/rat lethal dose (50 percent kill): 854 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
subcutaneous/guinea pig lowest published lethal dose: 150 mg/kgHBAMAK 4,1391,1935
subcutaneous/pigeon lowest published lethal dose: 500 mg/kgHBAMAK 4,1391,1935
subcutaneous/rabbit lowest published lethal dose: 550 mg/kgHBAMAK 4,1391,1935
subcutaneous/rat lowest published lethal dose: 1 gm/kgJAPMA8 29,152,1940
Tank with water/Trout lowest published toxic concentration: 720 µmol/L/16WLiver: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TIVIEQ 36,177,1996
unreported route/frog lowest published lethal dose: 250 mg/kgJAPMA8 29,152,1940

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 600 mg/kg/22D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPMA8 29,152,1940
oral/domestic animal lowest published toxic dose: 135 mg/kg/30D- continuousEndocrine: Other changes

Nutritional and Gross Metabolic: Changes in: Cl
JAPTO* 28,356,2008
oral/rat lowest published toxic dose: 47040 mg/kg/50W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Endocrine: Changes in thyroid weight

Blood: Other changes
JTEHD6 5,579,1979

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWEJIME* 17,529,2006

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-SWITZERLANDceiling concentration 2 mg(CN)/m3, inhal, skin, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 60570; Number of Industries 18; Total Number of Facilities 758; Number of Occupations 16; Total Number of Employees Exposed 17270; Total Number of Female Employees Exposed 3224
National Occupational Hazard Survey 1974Hazard Code 60570; Number of Industries 18; Total Number of Facilities 466; Number of Occupations 15; Total Number of Employees Exposed 3959

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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