Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Thiocyanic acid, methylene ester

RTECS #

XL1560000

CAS #

6317-18-6

Updated

August 2006

Molecular Weight

130.19

Molecular Formula

C3H2N2S2

Synonyms

CP 17879
Methylendirhodanid (Czech)
Methylendithiokyanat (Czech)
Methylene dithiocyanate
Methylenebis(thiocyanate)
Methylenedirhodanid (German)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /guinea pig 5 ppmTXCYAC 211,165,2005

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 260 mg/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTPTR* NIH-94-3381

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/mouse lethal dose (50 percent kill): 3600 µg/kgCSLNX* NX#03787
oral/rat lethal dose (50 percent kill): 55 mg/kgDIMCAL 12,404,1971
skin/rabbit lowest published lethal dose: 398 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
NTIS** OTS0545751
subcutaneous/rabbit lowest published lethal dose: 20 mg/kgBehavioral: Convulsions or effect on seizure threshold

Vascular: BP lowering not characterized in autonomic section
AEPPAE 150,257,1930

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 120 mg/kg/2W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-94-3381
oral/mouse lowest published toxic dose: 520 mg/kg/13W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Gastrointestinal: Other changes

Liver: Other changes
NTPTR* NIH-94-3381
oral/rat lowest published toxic dose: 240 mg/kg/2W- intermittentGastrointestinal: Necrotic changes

Endocrine: Changes in thymus weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-94-3381
oral/rat lowest published toxic dose: 520 mg/kg/13W- intermittentOlfaction: Other olfaction effects

Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Other proteins
NTPTR* NIH-94-3381

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,192,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81675; Number of Industries 26; Total Number of Facilities 1056; Number of Occupations 24; Total Number of Employees Exposed 24231; Total Number of Female Employees Exposed 995
National Occupational Hazard Survey 1974Hazard Code 81675; Number of Industries 8; Total Number of Facilities 159; Number of Occupations 3; Total Number of Employees Exposed 1670

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9235
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-32, October 2000
TOP