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Registry of Toxic Effects of Chemical Substances (RTECS)

2H-1,3,5-Thiadiazine-2-thione, tetrahydro-3,5-dimethyl-

RTECS #

XI2800000

CAS #

533-74-4

Updated

May 2007

Molecular Weight

162.29

Molecular Formula

C5H10N2S2

Synonyms

2-Thio-3,5-dimethyltetrahydro-1,3,5-thiadiazine
3,5-Dimethyl-1,2,3,5-tetrahydro-1,3,5-thiadiazinethione-2
3,5-Dimethyl-1,3,5-2H-tetrahydrothiadiazine-2-thione
3,5-Dimethyl-2-thionotetrahydro-1,3,5-thiadiazine
3,5-Dimethylperhydro-1,3,5-thiadiazin-2-thion (Czech, German)
3,5-Dimethyltetrahydro-1,3,5-2H-thiadiazine-2-thione
3,5-Dimethyltetrahydro-1,3,5-thiadiazine-2-thione
3,5-Dimethyltetrahydro-2H-1,3,5-thiadiazine-2-thione
3,5-Dimetil-peridro-1,3,5-tiadiazin-2-tione (Italian)
Basamid
Basamid - Purder
Basamid G
Basamid P
Crag 85W
Crag 974
Crag fungicide 974
D 35
Dazomet
Dimethylformocarbothialdine
DMTT
Fennosan B 100
Mylon (Czech)
Mylone
Mylone 85
N 521
Nalcon 243
Nefusan
Prezervit
Salvo (Czech)
Stauffer N 521
Tetrahydro-3,5-dimethyl-2H-1,3,5-thiadiazine-2-thione
Thiazon
Thiazone
Troysan 142
UCC 974

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,1103,1986
skin /human 0.1%/48HCODEDG 17,212,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 8400 mg/m3/4HPEMNDP 9,225,1991
intramuscular/Dog lowest published lethal dose: 250 mg/kgEye: Mydriasis (pupilliary dilation)

Vascular: BP elevation not characterized in autonomic section

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 9,521,1966
intraperitoneal/Dog lethal dose (50 percent kill): 47 mg/kgBehavioral: Convulsions or effect on seizure thresholdTXAPA9 9,521,1966
intraperitoneal/mouse lethal dose (50 percent kill): 98 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
NNGADV 17,S327,1992
intraperitoneal/rabbit lethal dose (50 percent kill): 127 mg/kgBehavioral: Convulsions or effect on seizure thresholdTXAPA9 9,521,1966
intraperitoneal/rat lethal dose (50 percent kill): 87 mg/kgBehavioral: Convulsions or effect on seizure thresholdTXAPA9 9,521,1966
oral/guinea pig lethal dose (50 percent kill): 160 mg/kgBehavioral: Convulsions or effect on seizure thresholdTXAPA9 9,521,1966
oral/mouse lethal dose (50 percent kill): 180 mg/kgBehavioral: Convulsions or effect on seizure thresholdTXAPA9 9,521,1966
oral/rabbit lethal dose (50 percent kill): 120 mg/kgBehavioral: Convulsions or effect on seizure thresholdTXAPA9 9,521,1966
oral/rat lethal dose (50 percent kill): 320 mg/kgBehavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature decrease
TXAPA9 9,521,1966
skin/mouse lethal dose (50 percent kill): 2400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
NNGADV 17,S327,1992
skin/rabbit lethal dose (50 percent kill): 7 gm/kgTXAPA9 9,521,1966
skin/rat lethal dose (50 percent kill): 2260 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
NNGADV 17,S327,1992
subcutaneous/mouse lethal dose (50 percent kill): 248 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
NNGADV 17,S327,1992
subcutaneous/rat lethal dose (50 percent kill): 470 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
NNGADV 17,S327,1992
unreported route/mouse lethal dose (50 percent kill): 650 mg/kg30ZDA9 -,430,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 3120 mg/kg/30D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 9,521,1966
oral/rat lowest published toxic dose: 22119 mg/kg/2Y- continuousBehavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 9,521,1966

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,171,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 26940; Number of Industries 9; Total Number of Facilities 1320; Number of Occupations 11; Total Number of Employees Exposed 25682; Total Number of Female Employees Exposed 528
National Occupational Hazard Survey 1974Hazard Code 26940; Number of Industries 5; Total Number of Facilities 203; Number of Occupations 10; Total Number of Employees Exposed 1206

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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