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2H - 1,3,5 - Thiadiazine - 2 - thione, tetrahydro - 3,5 - dimethyl -

RTECS #: XI2800000

CAS #: 533-74-4


UPDATE: May 2007 MW: 162.29 MF: C5H10N2S2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Thio - 3,5 - dimethyltetrahydro - 1,3,5 - thiadiazine
  2. 3,5 - Dimethylperhydro - 1,3,5 - thiadiazin - 2 - thion (Czech, German)
  3. 3,5 - Dimethyl - 1,2,3,5 - tetrahydro - 1,3,5 - thiadiazinethione - 2
  4. 3,5 - Dimethyltetrahydro - 1,3,5 - thiadiazine - 2 - thione
  5. 3,5 - Dimethyl - 1,3,5 - 2H - tetrahydrothiadiazine - 2 - thione
  6. 3,5 - Dimethyltetrahydro - 1,3,5 - 2H - thiadiazine - 2 - thione
  7. 3,5 - Dimethyltetrahydro - 2H - 1,3,5 - thiadiazine - 2 - thione
  8. 3,5 - Dimethyl - 2 - thionotetrahydro - 1,3,5 - thiadiazine
  9. 3,5 - Dimetil - peridro - 1,3,5 - tiadiazin - 2 - tione (Italian)
  10. Basamid
  11. Basamid G
  12. Basamid P
  13. Basamid - Purder
  14. Crag 85W
  15. Crag 974
  16. Crag fungicide 974
  17. D 35
  18. DMTT
  1. Dazomet
  2. Dimethylformocarbothialdine
  3. Fennosan B 100
  4. Mylon (Czech)
  5. Mylone
  6. Mylone 85
  7. N 521
  8. Nalcon 243
  9. Nefusan
  10. Prezervit
  11. Salvo (Czech)
  12. Stauffer N 521
  13. Tetrahydro - 3,5 - dimethyl - 2H - 1,3,5 - thiadiazine - 2 - thione
  14. Thiazon
  15. Thiazone
  16. Troysan 142
  17. UCC 974


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,1103,1986
skin
human
0.1%/48 hour CODEDG 17,212,1987


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 8,400 mg/m3/4 hour N/R PEMNDP 9,225,1991
intramuscular
dog
lowest published lethal dose: 250 mg/kg Eye: Mydriasis (pupilliary dilation)

Vascular: BP elevation not characterized in autonomic section

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 9,521,1966
intraperitoneal
dog
lethal dose (50 percent kill): 47 mg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 9,521,1966
intraperitoneal
mouse
lethal dose (50 percent kill): 98 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
NNGADV 17,S327,1992
intraperitoneal
rat
lethal dose (50 percent kill): 87 mg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 9,521,1966
intraperitoneal
rabbit
lethal dose (50 percent kill): 127 mg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 9,521,1966
oral
guinea pig
lethal dose (50 percent kill): 160 mg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 9,521,1966
oral
mouse
lethal dose (50 percent kill): 180 mg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 9,521,1966
oral
rat
lethal dose (50 percent kill): 320 mg/kg Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature decrease
TXAPA9 9,521,1966
oral
rabbit
lethal dose (50 percent kill): 120 mg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 9,521,1966
subcutaneous
mouse
lethal dose (50 percent kill): 248 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
NNGADV 17,S327,1992
subcutaneous
rat
lethal dose (50 percent kill): 470 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
NNGADV 17,S327,1992
skin
mouse
lethal dose (50 percent kill): 2,400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
NNGADV 17,S327,1992
skin
rat
lethal dose (50 percent kill): 2,260 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
NNGADV 17,S327,1992
skin
rabbit
lethal dose (50 percent kill): 7 gm/kg N/R TXAPA9 9,521,1966
unreported route
mouse
lethal dose (50 percent kill): 650 mg/kg N/R 30ZDA9 -,430,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 3,120 mg/kg/30 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 9,521,1966
oral
rat
lowest published toxic dose: 22,119 mg/kg/2 year- continuous Behavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 9,521,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,171,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 26940;
Number of Industries 5;
Total Number of Facilities 203;
Number of Occupations 10;
Total Number of Employees Exposed 1,206
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 26940;
Number of Industries 9;
Total Number of Facilities 1,320;
Number of Occupations 11;
Total Number of Employees Exposed 25,682;
Total Number of Female Employees Exposed 528


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as soil fumigant
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as soil fumigant

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Human Data
   Hormone
   Primary Irritant

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