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Registry of Toxic Effects of Chemical Substances (RTECS)

Thallium(I) sulfate (2:1)

RTECS #

XG6800000

CAS #

7446-18-6

Updated

September 201

Molecular Weight

504.80

Molecular Formula

O4S·2Tl

Synonyms

C.F.S.
CSF-giftweizen
Dithallium sulfate
Dithallium(1+) sulfate
Eccothal
M7-Giftkoerner
Rattengiftkonserve
RCRA waste number P115
Sulfuric acid, dithallium(1+) salt (8CI,9CI)
Sulfuric acid, thallium(1+) salt (1:2)
Thallium sulfate
Thallium(1) sulfate
Thallous sulfate
Tharattin
Zelio

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 57 mg/kg (60D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)ENVRAL 40,531,1986
oral/human 15 mg/kg (210D pregnant)Reproductive: Effects on newborn: Other neonatal measures or effectsHBPTO* 2,1381,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 236 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 18 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 60 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 14 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 0.034 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 0.12 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 0.25 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
intravenous/rabbit lowest published lethal dose: 25 mg/kgXATBAD 238,1,1931
oral/cat lowest published lethal dose: 40 mg/kgYKYUA6 28,329,1977
oral/Dog lowest published lethal dose: 16 mg/kgYKYUA6 28,329,1977
oral/duck lowest published lethal dose: 74 mg/kgJPETAB 48,478,1933
oral/human lowest published lethal dose: 2166 µg/kgYKYUA6 28,329,1977
oral/man lowest published lethal dose: 3 mg/kgEye: Other eye effects

Behavioral: Ataxia

Behavioral: Irritability
85ECAN 2,101,1978
oral/man lowest published toxic dose: 7 µg/kgBehavioral: Convulsions or effect on seizure threshold

Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair
CTOXAO 17,133,1980
oral/man lowest published lethal dose: 14 mg/kgPeripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Somnolence (general depressed activity)

Cardiac: Change in rate
JTSCDR 3,325,1978
oral/mouse lethal dose (50 percent kill): 23500 µg/kgGISAAA 29(2),23,1964
oral/mouse lethal dose (50 percent kill): 23.5 mg/kgBrain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
VCVN1* -,240,1988
oral/pig lowest published lethal dose: 2 mg/kgYKYUA6 28,329,1977
oral/quail lowest published lethal dose: 29640 µg/kgJPETAB 48,478,1933
oral/rat lethal dose (50 percent kill): 16 mg/kgYAKUD5 22,291,1980
oral/rat lowest published lethal dose: 24.7 mg/kgGastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VHTODE 42,325,2000
oral/wild bird lowest published lethal dose: 37 mg/kgJPETAB 48,478,1933
oral/woman lowest published toxic dose: 175 mg/kgPeripheral Nerve and Sensation: Paresthesia

Kidney, Ureter, and Bladder: Other changes in urine composition

Skin and Appendages: Other: Hair
JTCTDW 35,97,1997
skin/rat lethal dose (50 percent kill): 550 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
NNGADV 18,S209,1993
subcutaneous/mouse lethal dose (50 percent kill): 26600 µg/kgMEPAAX 30,257,1979
subcutaneous/mouse lethal dose (50 percent kill): 57.7 mg/kgBrain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
VCVN1* -,240,1988
subcutaneous/rat lowest published lethal dose: 13 mg/kgAPTOA6 12,260,1956
unreported route/rabbit lethal dose (50 percent kill): 25 mg/kg85JFAN A390,1983
unreported route/rat lethal dose (50 percent kill): 15 mg/kgYKYUA6 30,397,1979

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 58823 µg/kg/10D- intermittentGastrointestinal: Other changes

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JFALAX 5,15,1969
oral/rabbit lowest published toxic dose: 52.5 mg/kg/150D- intermittentGastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes primarily in glomeruli
VCVN1* -,242,1988
oral/rat lowest published toxic dose: 336 mg/kg/240D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHBPTO* 2,1381,2001
oral/rat lowest published toxic dose: 18.75 mg/kg/15D- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN1* -,242,1988
oral/rat lowest published toxic dose: 9 mg/kg/15D- intermittentBehavioral: Somnolence (general depressed activity)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 29(2),23,1964
subcutaneous/rabbit lowest published toxic dose: 52.5 mg/kg/150D- intermittentGastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes primarily in glomeruli
VCVN1* -,242,1988

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg(Tl)/m3 (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,165,2005
TOXICOLOGY REVIEWHBTME* ,827,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Tl)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(Tl)/m3, Skin, MAR2002
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Tl)/m3, short term exposure limit 0.4 mg(Tl)/m3, Skin, SEP2000
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Tl)/m3, skin, JAN2002
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.1 mg(Tl)/m3, MAC(short term exposure limit) 0.3 mg(Tl)/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Tl)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg(Tl)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Tl)/m3, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg(Tl)/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 mg(Tl)/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg(Tl)/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg(Tl)/m3 (skin)CFRGBR 29,1915.1000,1993

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
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