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Registry of Toxic Effects of Chemical Substances (RTECS)

Thallium(I) carbonate (2:1)

RTECS #

XG4000000

CAS #

6533-73-9

Updated

September 201

Molecular Weight

468.75

Molecular Formula

CO3·2Tl

Synonyms

Carbonic acid, dithallium(1+) salt
Dithallium carbonate
RCRA waste number U215
Thallous carbonate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat100 ng/kgGTPZAB 24(4),54,1980
DNA Damageembryo/rat1 µmol/LMUREAV 124,163,1983
DNA Damageembryo/mouse10 µmol/LMUREAV 124,163,1983
Dominant Lethal Testoral/rat5 ng/kgMUREAV 124,163,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 366 µg/kg (26W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)CHYCDW 21,141,1987
oral/mouse 36740 µg/kg (1-22D pregnant)Reproductive: Effects on newborn: Other postnatal measures or effectsWDZAEK 3,179,1989

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 20.4 mg/m3/86HBehavioral: Euphoria

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea
GISAAA -,8,1993
oral/mouse lethal dose (50 percent kill): 21 mg/kgBrain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
VCVN1* -,240,1988
oral/mouse lethal dose (50 percent kill): 21 mg/kgHYSAAV 29(2),26,1964
oral/rat lethal dose (50 percent kill): 15 mg/kgBrain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
VCVN1* -,240,1988
oral/rat lethal dose (50 percent kill): 21800 µg/kgWDZAEK 4,21,1990
skin/rat lethal dose (50 percent kill): 117 mg/kgOlfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
GTPZAB 24(4),54,1980
subcutaneous/mouse lethal dose (50 percent kill): 27 mg/kgBrain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
VCVN1* -,240,1988
subcutaneous/mouse lethal dose (50 percent kill): 27 mg/kgGastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TPKVAL 2,94,1961
subcutaneous/rat lethal dose (50 percent kill): 18 mg/kgGastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TPKVAL 2,94,1961
subcutaneous/rat lethal dose (50 percent kill): 18 mg/kgBrain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
VCVN1* -,240,1988
subcutaneous/rat lowest published lethal dose: 18 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 2,94,1961
unreported route/mouse lethal dose (50 percent kill): 20 pphVCVN1* -,244,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 100 µg/m3/24H/38D- continuousBlood: Other changesGISAAA 58(5),8,1993
inhalation/rat lowest published toxic concentration: 0.103 mg/m3/38D- continuousBehavioral: Change in psychophysiological tests

Blood: Normocytic anemia

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
GISAAA -,8,1993
oral/mouse lowest published toxic dose: 2400 µg/kg/5D- intermittentBlood: Changes in spleenWDZAEK 4,78,1990
oral/rat lowest published toxic dose: 269 µg/kg/35W- intermittentBehavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
GISAAA 45(9),11,1980
oral/rat lowest published toxic dose: 196 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
WDZAEK 4,21,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg(Tl)/m3 (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWHBTME* ,827,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Tl)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(Tl)/m3, Skin, MAR2002
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Tl)/m3, short term exposure limit 0.4 mg(Tl)/m3, Skin, SEP2000
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Tl)/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg(Tl)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.1 mg(Tl)/m3, MAC(short term exposure limit) 0.3 mg(Tl)/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Tl)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg(Tl)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Tl)/m3, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg(Tl)/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 mg(Tl)/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg(Tl)/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg(Tl)/m3 (skin)CFRGBR 29,1915.1000,1993

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
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