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Thallium (I) carbonate (2:1)

RTECS #: XG4000000

CAS #: 6533-73-9


UPDATE: May 2009 MW: 468.75 MF: CO32Tl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Carbonic acid, dithallium (1+) salt
  2. Dithallium carbonate
  1. RCRA waste number U215
  2. Thallous carbonate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
rat
100 ng/kg GTPZAB 24(4),54,1980
dominant lethal test oral
rat
5 ng/kg MUREAV 124,163,1983
DNA damage mouse embryo 10 mol/L MUREAV 124,163,1983
DNA damage rat embryo 1 mol/L MUREAV 124,163,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 366 g/kg (26 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) CHYCDW 21,141,1987
oral
mouse
lowest published toxic dose: 36,740 g/kg (1-22 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects WDZAEK 3,179,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 20.4 mg/m3/86 hour Behavioral: Euphoria

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea
GISAAA -,8,1993
oral
mouse
lethal dose (50 percent kill): 21 mg/kg N/R HYSAAV 29(2),26,1964
oral
mouse
lethal dose (50 percent kill): 21 mg/kg Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
VCVN1* -,240,1988
oral
rat
lethal dose (50 percent kill): 21,800 g/kg N/R WDZAEK 4,21,1990
oral
rat
lethal dose (50 percent kill): 15 mg/kg Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
VCVN1* -,240,1988
subcutaneous
mouse
lethal dose (50 percent kill): 27 mg/kg Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
VCVN1* -,240,1988
subcutaneous
mouse
lethal dose (50 percent kill): 27 mg/kg Gastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TPKVAL 2,94,1961
subcutaneous
rat
lethal dose (50 percent kill): 18 mg/kg Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
VCVN1* -,240,1988
subcutaneous
rat
lowest published lethal dose: 18 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 2,94,1961
subcutaneous
rat
lethal dose (50 percent kill): 18 mg/kg Gastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TPKVAL 2,94,1961
skin
mouse
lethal dose (50 percent kill): 2 pph/1 hour N/R TPKVAL 2,94,1961
skin
rat
lethal dose (50 percent kill): 117 mg/kg Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
GTPZAB 24(4),54,1980
unreported route
mouse
lethal dose (50 percent kill): 20 pph N/R VCVN1* -,244,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 100 g/m3/24 hour/38 day- continuous Blood: Other changes GISAAA 58(5),8,1993
inhalation
rat
lowest published toxic concentration: 0.103 mg/m3/38 day- continuous Behavioral: Change in psychophysiological tests

Blood: Normocytic anemia

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
GISAAA -,8,1993
oral
mouse
lowest published toxic dose: 2,400 g/kg/5 day- intermittent Blood: Changes in spleen WDZAEK 4,78,1990
oral
rat
lowest published toxic dose: 269 g/kg/35 week- intermittent Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
GISAAA 45(9),11,1980
oral
rat
lowest published toxic dose: 196 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
WDZAEK 4,21,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Tl)/m3 (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
HBTME* ,827,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Tl)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Tl)/m3, Skin, MAR2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Tl)/m3, short term exposure limit 0.4 mg(Tl)/m3, Skin, SEP2000
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Tl)/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Tl)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg(Tl)/m3, MAC(short term exposure limit) 0.3 mg(Tl)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Tl)/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Tl)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 mg(Tl)/m3 (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 mg(Tl)/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBTME*
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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