Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Thallium

RTECS #

XG3425000

CAS #

7440-28-0

Updated

September 201

Molecular Weight

204.37

Molecular Formula

Tl

Synonyms

Ramor
Thallium (ACGIH:OSHA)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisunreported route/rat0.12 mg/kg/240D- intermittentVCVN1* -,242,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/human lowest published toxic dose: 48 mg/kgBehavioral: Hallucinations, distorted perceptions

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Body temperature decrease
NRTXDN 27,291,2006
oral/human lowest published toxic dose: 21 mg/kgPeripheral Nerve and Sensation: Paresthesia

Behavioral: Change in psychophysiological tests

Nutritional and Gross Metabolic: Body temperature decrease
NRTXDN 27,291,2006
oral/man lowest published toxic dose: 5714 µg/kgPeripheral Nerve and Sensation: Structural change in nerve or sheath

Eye: Change in extra- ocular muscles

Skin and Appendages: Other: Hair
ATXKA8 19,65,1961
oral/rat lowest published lethal dose: 30 mg/kgTOXID9 72,22,2003
unreported route/human lethal dose (50 percent kill): 7 mg/kgBrain and Coverings: Increased intracranial pressure

Cardiac: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
VCVN1* -,242,1988
unreported route/man lowest published lethal dose: 4412 µg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 0.12 mg/kg/240D- intermittentBehavioral: Alteration of classical conditioning

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVN1* -,242,1988
unreported route/rat lowest published toxic dose: 0.012 mg/kg/240D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVN1* -,242,1988

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg/m3 (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAPHRER 38,1509,2004
TOXICOLOGY REVIEWENTOX* -,165,2005
TOXICOLOGY REVIEWHBTME* ,827,2007
TOXICOLOGY REVIEWHTOPA* 1,701,2002
TOXICOLOGY REVIEWDERCL* 25,215,2007
TOXICOLOGY REVIEWNEUCL* 23,377,2005
TOXICOLOGY REVIEWNTAPM* -,629,1995

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 mg/m3 (skin)DTLVS* 3,256,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 1 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(Tl)/m3, Skin, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, MAY2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg/m3, short term exposure limit 0.4 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.1 mg(Tl)/m3, MAC(short term exposure limit) 0.3 mg(Tl)/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Tl)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg(Tl)/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 mg(Tl)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg(Tl)/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg(Tl)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THALLIUM, soluble compounds-air10H time-weighted average 0.1 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X3172; Number of Industries 3; Total Number of Facilities 158; Number of Occupations 5; Total Number of Employees Exposed 1662; Total Number of Female Employees Exposed 1308

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110856/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
OSHA ANALYTICAL METHOD #ID121
TOP