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Registry of Toxic Effects of Chemical Substances (RTECS)

2,5,8,11-Tetraoxadodecane

RTECS #

XF0665000

CAS #

112-49-2

Updated

August 2008

Molecular Weight

178.26

Molecular Formula

C8H18O4

Synonyms

Ansul ether 161
Glyme 4
Triethylene glycol dimethyl ether
Triglyme

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
heritable translocation testskin/Drosophila melanogaster0.34 mmol/LTOXID9 78,265,2004

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 7500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
NTIS** PB86-103215
oral/mouse 5 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 31,53A,1985
oral/mouse 7500 mg/kg (6-15D pregnant)Reproductive: Maternal effects: Uterus, cervix, vaginaNTIS** PB86-103215
oral/mouse 28 gm/kg (6-13D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)TCMUD8 7,29,1987
oral/rabbit 3500 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** PB87-181657
oral/rabbit 3500 mg/kg (6-19D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB87-181657
oral/rabbit 3325 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
FAATDF 19,238,1992
oral/mouse 28000 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)EVHPAZ 57,141,1984
oral/mouse 6.1 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** #PB85150456/AS
oral/mouse 3 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB85150456/AS
oral/mouse 25872 mg/kg (21W prior to copulation)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Sex ratio

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB85150456/AS
oral/rabbit 3500 mg/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** #PB87-181657
oral/rabbit 2450 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** #PB87-181657
oral/rabbit 2450 mg/kg (6-19D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB87-181657
oral/rabbit 2450 mg/kg (6-19D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemNTIS** #PB87-181657
oral/mouse 5000 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** #PB86-103215
oral/mouse 2500 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** #PB86-103215

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 4456 mg/kg/10D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)NTIS** OTS0543414

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 28000 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984
oral/mouse lowest published toxic dose: 2450 mg/kg/14D- continuousBehavioral: Food intake (animal)

Behavioral: Fluid intake
NTIS** #PB85150456/AS
oral/mouse lowest published toxic dose: 25872 mg/kg/21W- continuousLiver: Changes in liver weightNTIS** #PB85150456/AS
oral/mouse lowest published toxic dose: 25872 mg/kg/21W- continuousEndocrine: Changes in pituitary weightNTIS** #PB85150456/AS
oral/mouse lowest published toxic dose: 5000 mg/kg/10D- intermittentLiver: Changes in liver weightNTIS** #PB86-103215
oral/mouse lowest published toxic dose: 2500 mg/kg/10D- intermittentSkin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB86-103215
oral/rabbit lowest published toxic dose: 3500 mg/kg/14D- intermittentLiver: Changes in liver weightNTIS** #PB87-181657
oral/rabbit lowest published toxic dose: 2450 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB87-181657

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWREPTED 25,192,2008

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code E0064; Number of Industries 1; Total Number of Facilities 27; Number of Occupations 1; Total Number of Employees Exposed 270

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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