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Registry of Toxic Effects of Chemical Substances (RTECS)

1,3,5,7-Tetrazocine, octahydro-1,3,5,7-tetranitro-

RTECS #

XF7450000

CAS #

2691-41-0

Updated

February 2008

Molecular Weight

296.20

Molecular Formula

C4H8N8O8

Synonyms

beta-Hmy
Cyclotetramethylenetetranitramine
HMX
HW 4
LX 14-0
Octogen
Oktogen
Tetramethylenetetranitramine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg mildNTIS** AD-A173-743

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/Dog lowest published lethal dose: 40 mg/kgCardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes
EATR** EB-TR-73040
intravenous/guinea pig lethal dose (50 percent kill): 28 mg/kgEATR** EB-TR-73040
intravenous/rabbit lethal dose (50 percent kill): 10 mg/kgNTIS** AD-A173-743
intravenous/rat lethal dose (50 percent kill): 25 mg/kgNTIS** AD-A171-598
ocular/rabbit lowest published toxic dose: 25 mg/kgEye: Conjunctiva irritationTPKVAL 13,138,1973
oral/guinea pig lethal dose (50 percent kill): 300 mg/kgGISAAA 40(11),17,1975
oral/mouse lethal dose (50 percent kill): 1500 mg/kgGISAAA 40(11),17,1975
oral/rabbit lethal dose (50 percent kill): 50 mg/kgBehavioral: Convulsions or effect on seizure thresholdNTIS** AD-A171-598
oral/rat lethal dose (50 percent kill): 6490 mg/kgNTIS** AD-A173-743
skin/rabbit lethal dose (50 percent kill): 630 mg/kgBehavioral: Convulsions or effect on seizure thresholdNTIS** AD-A171-598
skin/rat lethal dose (50 percent kill): >5 gm/kgNTIS** AD-A173743
unreported route/mouse lethal dose (50 percent kill): 2700 mg/kgNTIS** AD-A159-418
unreported route/rat lethal dose (50 percent kill): 7300 mg/kgNTIS** AD-A159-418

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 4200 mg/kg/14D- continuousSkin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD-A173743
oral/mouse lowest published toxic dose: 2700 mg/kg/13W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD-A173743
oral/mouse lowest published toxic dose: 50000 mg/kg/10D- intermittentBrain and Coverings: Changes in circulation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 13,138,1973
oral/rat lowest published toxic dose: 153 mg/kg/22W- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning
GISAAA 40(11),17,1975
oral/rat lowest published toxic dose: 14 gm/kg/14D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD-A173743
oral/rat lowest published toxic dose: 24300 mg/kg/13W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)NTIS** AD-A173743

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5883; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 6

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101058/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
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