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1,3,5,7 - Tetrazocine, octahydro - 1,3,5,7 - tetranitro -

RTECS #: XF7450000

CAS #: 2691-41-0


UPDATE: February 2008 MW: 296.20 MF: C4H8N8O8


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Cyclotetramethylenetetranitramine
  2. HMX
  3. HW 4
  4. LX 14 - 0
  1. Octogen
  2. Oktogen
  3. Tetramethylenetetranitramine
  4. beta - Hmy


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg mild NTIS** AD-A173-743


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
dog
lowest published lethal dose: 40 mg/kg Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes
EATR** EB-TR-73040
intravenous
guinea pig
lethal dose (50 percent kill): 28 mg/kg N/R EATR** EB-TR-73040
intravenous
rat
lethal dose (50 percent kill): 25 mg/kg N/R NTIS** AD-A171-598
intravenous
rabbit
lethal dose (50 percent kill): 10 mg/kg N/R NTIS** AD-A173-743
ocular
rabbit
lowest published toxic dose: 25 mg/kg Eye: Conjunctiva irritation TPKVAL 13,138,1973
oral
guinea pig
lethal dose (50 percent kill): 300 mg/kg N/R GISAAA 40(11),17,1975
oral
mouse
lethal dose (50 percent kill): 1,500 mg/kg N/R GISAAA 40(11),17,1975
oral
rat
lethal dose (50 percent kill): 6,490 mg/kg N/R NTIS** AD-A173-743
oral
rabbit
lethal dose (50 percent kill): 50 mg/kg Behavioral: Convulsions or effect on seizure threshold NTIS** AD-A171-598
skin
rat
lethal dose (50 percent kill): >5 gm/kg N/R NTIS** AD-A173743
skin
rabbit
lethal dose (50 percent kill): 630 mg/kg Behavioral: Convulsions or effect on seizure threshold NTIS** AD-A171-598
unreported route
mouse
lethal dose (50 percent kill): 2,700 mg/kg N/R NTIS** AD-A159-418
unreported route
rat
lethal dose (50 percent kill): 7,300 mg/kg N/R NTIS** AD-A159-418


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 4,200 mg/kg/14 day- continuous Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD-A173743
oral
mouse
lowest published toxic dose: 2,700 mg/kg/13 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD-A173743
oral
mouse
lowest published toxic dose: 50,000 mg/kg/10 day- intermittent Brain and Coverings: Changes in circulation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 13,138,1973
oral
rat
lowest published toxic dose: 153 mg/kg/22 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning
GISAAA 40(11),17,1975
oral
rat
lowest published toxic dose: 14 gm/kg/14 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD-A173743
oral
rat
lowest published toxic dose: 24,300 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) NTIS** AD-A173743


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5883;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 6


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101058/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

EATR** U.S. Army, Edgewood Arsenal Technical Report. (Aberdeen Proving Ground, MD 21010)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

RTECS Compound Description:
   Primary Irritant

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