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Registry of Toxic Effects of Chemical Substances (RTECS)

Terephthalic acid

RTECS #

WZ0875000

CAS #

100-21-0

Updated

September 201

Molecular Weight

166.14

Molecular Formula

C8H6O4

Synonyms

1,4-Benzenedicarboxylic acid
Acide terephtalique (French)
Kyselina tereftalova (Czech)
p-Benzenedicarboxylic acid
p-Carboxybenzoic acid
p-Dicarboxybenzoic acid
TA-33MP
Terephthalic acid (ACGIH)
WR 16262

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,317,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 147231 mg/kg (90D pre-21D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
HPV137 -,-,2003

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 92.4 gm/kg/4W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Facilitates action of known carcinogens
TXAPA9 210,24,2006

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 1430 mg/kgCPBTAL 16,1655,1968
intraperitoneal/mouse lowest published lethal dose: 800 mg/kgHPV137 -,-,2003
intravenous/Dog lowest published lethal dose: 767 mg/kgTXAPA9 18,469,1971
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationTPKVAL 7,91,1965
oral/mouse lethal dose (50 percent kill): 3200 mg/kgKODAK* 21MAY1971
oral/mouse lowest published toxic dose: 500 mg/kgBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes
TPKVAL 7,91,1965
oral/mouse lowest published toxic dose: 5000 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis
TPKVAL 7,91,1965
oral/mouse lowest published lethal dose: 10000 mg/kgBehavioral: Food intake (animal)

Behavioral: Alteration of classical conditioning

Vascular: Other changes
TPKVAL 7,91,1965
oral/rat lethal dose (50 percent kill): >6400 mg/kgKODAK* 21MAY1971
oral/rat lethal dose (50 percent kill): >5000 mg/kgGastrointestinal: Hypermotility, diarrheaHPV137 -,-,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 0.004 gm/m3/5D- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Respiratory stimulation

Skin: After systemic exposure: Dermatitis, other
TPKVAL 7,91,1965
inhalation/rat lowest published toxic concentration: 0.004 gm/m3/61D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Vascular: Other changes
TPKVAL 7,91,1965
inhalation/rat lowest published toxic concentration: 0.004 gm/m3/91D- intermittentBehavioral: General anestheticTPKVAL 7,91,1965
inhalation/rat lowest published toxic concentration: 0.004 gm/m3/0.5Y- intermittentBrain and Coverings: Other degenerative changes

Cardiac: Other changes

Vascular: Structural changes in vessels
TPKVAL 7,91,1965
inhalation/rat lowest published toxic concentration: 3.3 mg/m3/28D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchiHPV137 -,-,2003
oral/mouse lowest published toxic dose: 7200 mg/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV137 -,-,2003
oral/mouse lowest published toxic dose: 5964 mg/kg/7D- intermittentLiver: Liver function tests impairedCPBTAL 16,1655,1968
oral/rat lowest published toxic dose: 17028 mg/kg/90D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TXCYAC 201,59,2004
oral/rat lowest published toxic dose: 523665 mg/kg/90D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TXCYAC 201,59,2004
oral/rat lowest published toxic dose: 92400 mg/kg/22W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 210,24,2006
oral/rat lowest published toxic dose: 462000 mg/kg/22W- continuousKidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Changes in bladder weight
TXAPA9 210,24,2006
oral/rat lowest published toxic dose: 202.5 gm/kg/90D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
HPV137 -,-,2003
oral/rat lowest published toxic dose: 364 gm/kg/1Y- continuousEye: Other eye effects

Liver: Changes in liver weight
NTIS** OTS0570926
oral/rat lowest published toxic dose: 104 gm/kg/2Y- continuousBrain and Coverings: Changes in brain weight

Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTIS** OTS0543783
oral/rat lowest published toxic dose: 108 gm/kg/90D- intermittentKidney, Ureter, and Bladder: Other changesNTIS** OTS0546333
oral/rat lowest published toxic dose: 730000 mg/kg/2Y- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV137 -,-,2003
oral/rat lowest published toxic dose: 1825000 mg/kg/2Y- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV137 -,-,2003
oral/rat lowest published toxic dose: 393.75 gm/kg/15W- intermittentKidney, Ureter, and Bladder: Hematuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV137 -,-,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWBPCT** -,183,1974
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWFCTOD7 49,1877,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 mg/m3, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 10 mg/m3, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, KZG-week 0.2 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82013; Number of Industries 8; Total Number of Facilities 282; Number of Occupations 16; Total Number of Employees Exposed 6456; Total Number of Female Employees Exposed 2563
National Occupational Hazard Survey 1974Hazard Code 82013; Number of Industries 26; Total Number of Facilities 1682; Number of Occupations 42; Total Number of Employees Exposed 22732

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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