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Terephthalic acid

RTECS #: WZ0875000

CAS #: 100-21-0


UPDATE: February 2009 MW: 166.14 MF: C8H6O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,4 - Benzenedicarboxylic acid
  2. Acide terephtalique (French)
  3. Kyselina tereftalova (Czech)
  4. TA - 33MP
  5. Terephthalic acid (ACGIH)
  1. WR 16262
  2. p - Benzenedicarboxylic acid
  3. p - Carboxybenzoic acid
  4. p - Dicarboxybenzoic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,317,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 92.4 gm/kg/4 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Facilitates action of known carcinogens
TXAPA9 210,24,2006


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 1,430 mg/kg N/R CPBTAL 16,1655,1968
intravenous
dog
lowest published lethal dose: 767 mg/kg N/R TXAPA9 18,469,1971
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TPKVAL 7,91,1965
oral
mouse
lethal dose (50 percent kill): 3,200 mg/kg N/R KODAK* 21MAY1971
oral
mouse
lowest published toxic dose: 500 mg/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes
TPKVAL 7,91,1965
oral
mouse
lowest published toxic dose: 5,000 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis
TPKVAL 7,91,1965
oral
mouse
lethal dose : 10,000 mg/kg Behavioral: Food intake (animal)

Behavioral: Alteration of classical conditioning

Vascular: Other changes
TPKVAL 7,91,1965
oral
rat
lethal dose (50 percent kill): >6,400 mg/kg N/R KODAK* 21MAY1971
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 7,91,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/5 day- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Respiratory stimulation

Skin: After systemic exposure: Dermatitis, other
TPKVAL 7,91,1965
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/61 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Vascular: Other changes
TPKVAL 7,91,1965
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/91 day- intermittent Behavioral: General anesthetic TPKVAL 7,91,1965
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/0.5 year- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Vascular: Structural changes in vessels
TPKVAL 7,91,1965
oral
mouse
lowest published toxic dose: 5,964 mg/kg/7 day- intermittent Liver: Liver function tests impaired CPBTAL 16,1655,1968
oral
rat
lowest published toxic dose: 364 gm/kg/1 year- continuous Eye: Other eye effects

Liver: Changes in liver weight
NTIS** OTS0570926
oral
rat
lowest published toxic dose: 104 gm/kg/2 year- continuous Brain and Coverings: Changes in brain weight

Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTIS** OTS0543783
oral
rat
lowest published toxic dose: 108 gm/kg/90 day- intermittent Kidney, Ureter, and Bladder: Other changes NTIS** OTS0546333
oral
rat
lowest published toxic dose: 17,028 mg/kg/90 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXCYAC 201,59,2004
oral
rat
lowest published toxic dose: 523,665 mg/kg/90 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TXCYAC 201,59,2004
oral
rat
lowest published toxic dose: 92,400 mg/kg/22 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 210,24,2006
oral
rat
lowest published toxic dose: 462,000 mg/kg/22 week- continuous Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Changes in bladder weight
TXAPA9 210,24,2006
skin
mouse
lowest published toxic dose: 100 pph/2 day- intermittent Skin: After topical application: Primary irritation TPKVAL 7,91,1965
skin
mouse
lowest published toxic dose: 100 pph/10 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
TPKVAL 7,91,1965


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
BPCT** -,183,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 mg/m3, OCT 2002
Occupational Exposure Limit - GERMANY MAK 0.1 mg/m3 inhalable), 2005
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3,KZG- week 0.2 mg/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82013;
Number of Industries 26;
Total Number of Facilities 1,682;
Number of Occupations 42;
Total Number of Employees Exposed 22,732
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82013;
Number of Industries 8;
Total Number of Facilities 282;
Number of Occupations 16;
Total Number of Employees Exposed 6,456;
Total Number of Female Employees Exposed 2,563


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of POLYETHYLENE TEREPHTHALATE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BPCT** Progress Report from the Environmental Protection Agency to NIOSH on Benzenepolycarboxylates, 1974
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used in production of POLYETHYLENE TEREPHTHALATE

Top 50 chemical production: 5.64 billions lbs in 1992, 7.64 billions in 1991

NIOSH PROFILE (TEREPHTHALIC ACID), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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