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Terephthaloyl chloride

RTECS #: WZ1797000

CAS #: 100-20-9


UPDATE: February 2008 MW: 203.02 MF: C8H4Cl2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,4 - Benzenedicarbonyl chloride
  2. 1,4 - Benzenedicarbonyl dichloride
  3. Terephthalic acid chloride
  4. Terephthalic acid dichloride
  5. Terephthalic dichloride
  1. Terephthaloyl dichloride
  2. p - Phenylenedicarbonyl dichloride
  3. p - Phthaloyl chloride
  4. p - Phthaloyl dichloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 4,122 mg/kg (26 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) GISAAA 49(12),35,1984
oral
rat
lowest published toxic dose: 4,122 mg/kg (26 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders GISAAA 49(12),35,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 0.4 gm/m3/5 minute Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
TPKVAL 9,158,1967
inhalation
mouse
lethal concentration : 0.4 gm/m3/2 hour Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Cyanosis
TPKVAL 9,158,1967
inhalation
rat
lethal concentration (50 percent kill): 700 mg/m3/4 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory stimulation
NTIS** OTS0533726
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Lacrimation

Eye: Conjunctiva irritation

Eye: Other eye effects
TPKVAL 9,158,1967
oral
mouse
lethal dose (50 percent kill): 2,140 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
GISAAA 49(12),35,1984
oral
rat
lethal dose (50 percent kill): 2,500 mg/kg N/R 34ZIAG -,475,1969
oral
rabbit
lethal dose (50 percent kill): 950 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
GISAAA 49(12),35,1984
skin
rabbit
lethal dose : >200 mg/kg N/R NTIS** OTS0533726


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 0.4 gm/m3/45 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi TPKVAL 9,158,1967
inhalation
mouse
lowest published toxic concentration: 0.4 gm/m3/45 day- intermittent Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 9,158,1967
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/45 day- intermittent Eye: Conjunctiva irritation

Blood: Changes in other cell count (unspecified)
TPKVAL 9,158,1967
oral
rat
lowest published toxic dose: 4,168 mg/kg/26 week- intermittent Liver: Other changes GISAAA 49(12),40,1984
skin
guinea pig
lowest published toxic dose: 10,000 mg/kg/10 day- intermittent Skin: After topical application: Primary irritation TPKVAL 9,158,1967
skin
rabbit
lowest published toxic dose: 750 mg/kg/3 day- intermittent Skin: After topical application: Primary irritation TPKVAL 9,158,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4188;
Number of Industries 1;
Total Number of Facilities 27;
Number of Occupations 1;
Total Number of Employees Exposed 212


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as plastics and polymer intermediates, catalyst
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as plastics and polymer intermediates, catalyst

RTECS Compound Description:
   Reproductive Effector

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