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Registry of Toxic Effects of Chemical Substances (RTECS)

Terephthaloyl chloride

RTECS #

WZ1797000

CAS #

100-20-9

Updated

April 2012

Molecular Weight

203.02

Molecular Formula

C8H4Cl2O2

Synonyms

1,4-Benzenedicarbonyl chloride
1,4-Benzenedicarbonyl dichloride
p-Phenylenedicarbonyl dichloride
p-Phthaloyl chloride
p-Phthaloyl dichloride
Terephthalic acid chloride
Terephthalic acid dichloride
Terephthalic dichloride
Terephthaloyl dichloride

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 4122 mg/kg (26W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)GISAAA 49(12),35,1984
oral/rat 4122 mg/kg (26W prior to copulation)Reproductive: Maternal effects: Menstrual cycle changes or disordersGISAAA 49(12),35,1984

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 0.004 gm/m3/5MBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
TPKVAL 9,158,1967
inhalation/mouse Lowest published lethal concentration: 0.004 gm/m3/2HLung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Cyanosis
TPKVAL 9,158,1967
inhalation/rat lethal concentration (50 percent kill): 700 mg/m3/4HEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory stimulation
NTIS** OTS0533726
ocular/rabbit lowest published toxic dose: 100 pphEye: Lacrimation

Eye: Conjunctiva irritation

Eye: Other eye effects
TPKVAL 9,158,1967
oral/mouse lethal dose (50 percent kill): 2140 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
GISAAA 49(12),35,1984
oral/rabbit lethal dose (50 percent kill): 950 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
GISAAA 49(12),35,1984
oral/rat lethal dose (50 percent kill): 2500 mg/kg34ZIAG -,475,1969
skin/rabbit Lethal dose: >200 mg/kgNTIS** OTS0533726

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 0.0004 gm/m3/45D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchiTPKVAL 9,158,1967
inhalation/mouse lowest published toxic concentration: 0.0004 gm/m3/45D- intermittentBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 9,158,1967
inhalation/rat lowest published toxic concentration: 0.0004 gm/m3/45D- intermittentEye: Conjunctiva irritation

Blood: Changes in other cell count (unspecified)
TPKVAL 9,158,1967
oral/rat lowest published toxic dose: 4168 mg/kg/26W- intermittentLiver: Other changesGISAAA 49(12),40,1984
skin/guinea pig lowest published toxic dose: 10000 mg/kg/10D- intermittentSkin: After topical application: Primary irritationTPKVAL 9,158,1967
skin/rabbit lowest published toxic dose: 750 mg/kg/3D- intermittentSkin: After topical application: Primary irritationTPKVAL 9,158,1967

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4188; Number of Industries 1; Total Number of Facilities 27; Number of Occupations 1; Total Number of Employees Exposed 212

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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