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Terephthalic acid, dimethyl ester

RTECS #: WZ1225000

CAS #: 120-61-6


UPDATE: February 2008 MW: 194.20 MF: C10H10O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,4 - Benzenedicarboxylic acid, dimethyl ester (9CI)
  2. DMT
  3. Di - Me terephthalate
  4. Dimethyl 1,4 - benzenedicarboxylate
  5. Dimethylester kyseliny tereftalove (Czech)
  6. Dimethyl p - phthalate
  1. Dimethyl terephthalate
  2. Methyl 4 - carbomethoxybenzoate
  3. Methyl p - (methoxycarbonyl) benzoate
  4. NCI - C50055
  5. Terephthalic acid methyl ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,386,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1,250 mg/L/2 hour (+enzymatic activation step) EMMUEG 44,329,2004
micronucleus test intraperitoneal
mouse
200 Ámol/kg MUREAV 204,703,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/20 minute N/R TPKVAL 5,107,1963
intraperitoneal
rat
lethal dose (50 percent kill): 3,900 mg/kg Behavioral: Muscle weakness AIHAAP 34,455,1973
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation

Vascular: Regional or general arteriolar constriction

Vascular: Regional or general arteriolar or venous dilation
TPKVAL 5,107,1963
oral
mouse
lowest published toxic dose: 450 mg/kg Gastrointestinal: Necrotic changes TPKVAL 5,107,1963
oral
mouse
lowest published toxic dose: 10,000 mg/kg Cardiac: Other changes

Vascular: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 5,107,1963
oral
rat
lethal dose (50 percent kill): >3,200 mg/kg N/R 14CYAT 2,1906,1963
skin
guinea pig
lethal dose (50 percent kill): >5 gm/kg N/R 14CYAT 2,1906,1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1 mg/m3/2 hour/22 week- intermittent Olfaction: Other olfaction effects

Vascular: BP lowering not characterized in autonomic section

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 3.5 gm/m3/61 day- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Changes in erythrocyte (RBC) count
TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/12 day- intermittent Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/16 day- intermittent Olfaction: Other olfaction effects

Eye: Conjunctiva irritation
TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/61 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/153 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Emphysema
TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/76 day- intermittent Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/3 day- intermittent Behavioral: Somnolence (general depressed activity) TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/11 day- intermittent Behavioral: Excitement TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/45 day- intermittent Eye: Mydriasis (pupilliary dilation)

Vascular: Other changes
TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/153 day- intermittent Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/30 day- intermittent Vascular: BP lowering not characterized in autonomic section TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/91 day- intermittent Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
TPKVAL 5,107,1963
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/61 day- intermittent Blood: Changes in leukocyte (WBC) count TPKVAL 5,107,1963
oral
rat
lowest published toxic dose: 57,600 mg/kg/14 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 34,455,1973
skin
mouse
lowest published toxic dose: 100 pph/3 day- intermittent Skin: After topical application: Primary irritation TPKVAL 5,107,1963
skin
rabbit
lowest published toxic dose: 100 pph/10 day- intermittent Skin: After topical application: Primary irritation TPKVAL 5,107,1963


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
BPCT** -,183,1974
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83502;
Number of Industries 5;
Total Number of Facilities 58;
Number of Occupations 7;
Total Number of Employees Exposed 993
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83502;
Number of Industries 3;
Total Number of Facilities 104;
Number of Occupations 3;
Total Number of Employees Exposed 2,467;
Total Number of Female Employees Exposed 204


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of POLYETHYLENE TEREPHTHALATE
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouse NCITR* NCI-TR-121,1979
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-121,1979


REFERENCES:

CODEN
REFERENCE

14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BPCT** Progress Report from the Environmental Protection Agency to NIOSH on Benzenepolycarboxylates, 1974
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used in production of POLYETHYLENE TEREPHTHALATE

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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