Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Terephthalic acid, dimethyl ester

RTECS #

WZ1225000

CAS #

120-61-6

Updated

July 2012

Molecular Weight

194.20

Molecular Formula

C10H10O4

Synonyms

1,4-Benzenedicarboxylic acid, dimethyl ester (9CI)
Di-Me terephthalate
Dimethyl 1,4-benzenedicarboxylate
Dimethyl p-phthalate
Dimethyl terephthalate
Dimethylester kyseliny tereftalove (Czech)
DMT
Methyl 4-carbomethoxybenzoate
Methyl p-(methoxycarbonyl)benzoate
NCI-C50055
Terephthalic acid methyl ester

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,386,1986
eye /rabbit 500 mg mildHPV211 -,-,2006

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testintraperitoneal/mouse200 µmol/kgMUREAV 204,703,1988
mutation in microorganisms/Salmonella typhimurium1250 mg/L/2H (+enzymatic activation step)EMMUEG 44,329,2004

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 86250 mg/kg (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
HPV211 -,-,2006

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/20MTPKVAL 5,107,1963
inhalation/rat lethal concentration (50 percent kill): >6000 mg/m3/2HLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
HPV211 -,-,2006
intraperitoneal/rat lethal dose (50 percent kill): 3900 mg/kgBehavioral: Muscle weaknessAIHAAP 34,455,1973
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritation

Vascular: Regional or general arteriolar constriction

Vascular: Regional or general arteriolar or venous dilation
TPKVAL 5,107,1963
oral/mouse lowest published toxic dose: 450 mg/kgGastrointestinal: Necrotic changesTPKVAL 5,107,1963
oral/mouse lowest published toxic dose: 10000 mg/kgCardiac: Other changes

Vascular: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 5,107,1963
oral/rat lethal dose (50 percent kill): >3200 mg/kg14CYAT 2,1906,1963
skin/guinea pig lethal dose (50 percent kill): >5000 mg/kgHPV211 -,-,2006
skin/guinea pig lowest published toxic dose: 1 gm/kgSkin: After topical application: Primary irritationHPV211 -,-,2006

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1 mg/m3/2H/22W- intermittentOlfaction: Other olfaction effects

Vascular: BP lowering not characterized in autonomic section

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 3.5 gm/m3/61D- intermittentLung, Thorax, or Respiration: Other changes

Blood: Changes in erythrocyte (RBC) count
TPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.05 gm/m3/12D- intermittentBehavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.05 gm/m3/16D- intermittentOlfaction: Other olfaction effects

Eye: Conjunctiva irritation
TPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.05 gm/m3/61D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.05 gm/m3/153D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Emphysema
TPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.05 gm/m3/76D- intermittentBrain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/3D- intermittentBehavioral: Somnolence (general depressed activity)TPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/11D- intermittentBehavioral: ExcitementTPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/45D- intermittentEye: Mydriasis (pupilliary dilation)

Vascular: Other changes
TPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/153D- intermittentVascular: Structural changes in vessels

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/30D- intermittentVascular: BP lowering not characterized in autonomic sectionTPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/91D- intermittentBlood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
TPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/61D- intermittentBlood: Changes in leukocyte (WBC) countTPKVAL 5,107,1963
inhalation/rat lowest published toxic concentration: 1 mg/m3/20W- intermittentBehavioral: Somnolence (general depressed activity)

Vascular: BP lowering not characterized in autonomic section

Blood: Changes in erythrocyte (RBC) count
HPV211 -,-,2006
inhalation/rat lowest published toxic concentration: 40 mg/m3/20W- intermittentCardiac: Cardiomyopathy including infarction

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV211 -,-,2006
oral/rat lowest published toxic dose: 57600 mg/kg/14W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainAIHAAP 34,455,1973
oral/rat lowest published toxic dose: 15.75 gm/kg/14D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV137 -,-,2003
oral/rat lowest published toxic dose: 50000 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV211 -,-,2006
oral/rat lowest published toxic dose: 18480 mg/kg/14D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV211 -,-,2006
oral/rat lowest published toxic dose: 60 gm/kg/16D- intermittentKidney, Ureter, and Bladder: Hematuria

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder
HPV211 -,-,2006
oral/rat lowest published toxic dose: 120 gm/kg/16D- intermittentKidney, Ureter, and Bladder: Hematuria

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV211 -,-,2006
oral/rat lowest published toxic dose: 61056 mg/kg/96D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV211 -,-,2006
subcutaneous/rat lowest published toxic dose: 75 gm/kg/10W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV211 -,-,2006

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWBPCT** -,183,1974
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83502; Number of Industries 3; Total Number of Facilities 104; Number of Occupations 3; Total Number of Employees Exposed 2467; Total Number of Female Employees Exposed 204
National Occupational Hazard Survey 1974Hazard Code 83502; Number of Industries 5; Total Number of Facilities 58; Number of Occupations 7; Total Number of Employees Exposed 993

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouseNCITR* NCI-TR-121,1979
NCI Carcinogenesis Bioassay (feed);no evidence:ratNCITR* NCI-TR-121,1979
On EPA IRIS database
TOP