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Registry of Toxic Effects of Chemical Substances (RTECS)

Sulfur trioxide

RTECS #

WT4830000

CAS #

7446-11-9

Updated

November 2009

Molecular Weight

80.06

Molecular Formula

O3S

Synonyms

Sulfan
Sulfuric anhydride
Sulfuric oxide
Sulphur trioxide

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 30 mg/m3/6HLiver: Hepatitis (hepatocellular necrosis), diffuse

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Endocrine: Other changes
JPBAA7 68,197,1954
inhalation/human lowest published toxic concentration: 30 mg/m3Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes
JPBAA7 68,197,1954

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 54,41,1992
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 54,41,1992
TOXICOLOGY REVIEWAEHLAU 16,903,1968

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0745; Number of Industries 17; Total Number of Facilities 2524; Number of Occupations 27; Total Number of Employees Exposed 56102; Total Number of Female Employees Exposed 3077
National Occupational Hazard Survey 1974Hazard Code M0745; Number of Industries 20; Total Number of Facilities 1316; Number of Occupations 39; Total Number of Employees Exposed 51404

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/122038)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
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