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Sulfuric acid, monododecyl ester, sodium salt

RTECS #: WT1050000

CAS #: 151-21-3


UPDATE: May 2009 MW: 288.42 MF: C12H25O4S•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. AI3 - 00356
  2. Akyposal SDS
  3. Aquarex ME
  4. Aquarex methyl
  5. Avirol 101
  6. Avirol 118 conc
  7. Berol 452
  8. CP 75424
  9. Carsonol SLS
  10. Carsonol SLS Paste B
  11. Carsonol SLS Special
  12. Conco Sulfate WAG
  13. Conco Sulfate WAN
  14. Conco Sulfate WAS
  15. Conco sulfate WA
  16. Conco sulfate WA - 1200
  17. Conco sulfate WA - 1245
  18. Conco sulfate WN
  19. Cycloryl 21
  20. Cycloryl 31
  21. Cycloryl 580
  22. Cycloryl 585N
  23. Dehydag sulfate GL emulsion
  24. Dehydag sulphate GL emulsion
  25. Detergent 66
  26. Dodecyl alcohol, hydrogen sulfate, sodium salt
  27. Dodecyl sodium sulfate
  28. Dodecyl sulfate sodium
  29. Dodecyl sulfate, sodium salt
  30. Dreft
  31. Duponal
  32. Duponal WAQE
  33. Duponol
  34. Duponol C
  35. Duponol ME
  36. Duponol methyl
  37. Duponol QX
  38. Duponol WA
  39. Duponol WA Dry
  40. Duponol WAQ
  41. Duponol WAQA
  42. Duponol WAQE
  43. Duponol WAQM
  44. EMAL 10
  45. EMAL O
  46. Emersal 6400
  47. Empicol LPZ
  48. Empicol LS 30
  49. Empicol LX 28
  50. Emulsifier No. 104
  51. Finasol osr (sub 2)
  52. Gardinol
  53. Hexamol SLS
  54. Incronol SLS
  55. Irium
  56. Jordanol SL - 300
  57. Lanette wax - S
  58. Lauryl sodium sulfate
  59. Lauryl sulfate, sodium salt
  60. Laurylsiran sodny (Czech)
  61. Maprofix 563
  62. Maprofix LK
  63. Maprofix NEU
  64. Maprofix WAC
  65. Maprofix wac - LA
  66. Melanol CL
  67. Melanol CL 30
  68. Monododecyl sodium sulfate
  69. Monogen Y 100
  70. Montopol LA paste
  71. NCI - C50191
  72. Neutrazyme
  73. Nikkol SLS
  74. Odoripon AL 95
  75. Orvus WA paste
  76. P and G emulsifier 104
  77. Perlandrol L
  78. Product No. 75
  79. Product No. 161
  1. Quolac EX - UB
  2. Rewopol NLS 30
  3. Richonol A
  4. Richonol AF
  5. Richonol C
  6. SDS
  7. SLS
  8. Sinnopon LS 95
  9. Sinnopon LS 100
  10. Sintapon L
  11. Sipex OP
  12. Sipex SB
  13. Sipex SD
  14. Sipex SP
  15. Sipex UB
  16. Sipon LS
  17. Sipon LS 100
  18. Sipon LSB
  19. Sipon PD
  20. Sipon WD
  21. Sodium dodecyl sulfate
  22. Sodium n - dodecyl sulfate
  23. Sodium dodecyl sulphate
  24. Sodium lauryl sulfate
  25. Sodium lauryl sulphate
  26. Sodium monododecyl sulfate
  27. Sodium monolauryl sulfate
  28. Solsol needles
  29. Standapol 112 conc
  30. Standapol WA - AC
  31. Standapol WAQ
  32. Standapol WAQ Special
  33. Standapol WAS 100
  34. Steinapol NLS 90
  35. Stepanol ME
  36. Stepanol ME Dry
  37. Stepanol ME Dry AW
  38. Stepanol methyl
  39. Stepanol methyl dry AW
  40. Stepanol T 28
  41. Stepanol WA
  42. Stepanol WA - 100
  43. Stepanol WAC
  44. Stepanol WA paste
  45. Stepanol WAQ
  46. Sterling WA paste
  47. Sterling WAQ - CH
  48. Sterling waq - cosmetic
  49. Sulfetal L 95
  50. Sulfopon WA 1
  51. Sulfopon WA 2
  52. Sulfopon WA 3
  53. Sulfopon WA 1 special
  54. Sulfotex WA
  55. Sulfotex WALA
  56. Swascol 3L
  57. Swascol 4L
  58. Swascol 1P
  59. Syntapon
  60. Syntapon L
  61. Syntapon L pasta (Czech)
  62. TVM 474
  63. Tarapon K 12
  64. Texapon DL conc.
  65. Texapon K12
  66. Texapon K - 1296
  67. Texapon L 100
  68. Texapon V HC
  69. Texapon V HC powder
  70. Texapon ZHC
  71. Texapon Z high conc. needles
  72. Trepenol WA
  73. Ultra sulfate SL - 1
  74. WAQE
  75. Witcolate A
  76. Witcolate A powder
  77. Witcolate C
  78. n - Dodecyl sulfate sodium


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 28ZPAK -,305,1972
eye
rabbit
250 µg mild AROPAW 34,99,1945
eye
rabbit
2 mg mild DCTODJ 1,305,1978
eye
rabbit
10 mg moderate TXAPA9 55,501,1980
skin
dog
25 mg/24 hour mild JSCCA5 23,371,1972
skin
guinea pig
25 mg/24 hour mild JSCCA5 23,371,1972
skin
human
250 mg/24 hour mild TXAPA9 31,481,1975
skin
human
25 mg/24 hour mild JSCCA5 23,371,1972
skin
human
0.6%/24 hour mild JIDEAE 10,159,1995
skin
human
0.1%/24 hour moderate JIDEAE 76,341,1996
skin
human
0.5%/23 hour JIDEAE 76,450,1996
skin
human
0.5%/47 hour mild JIDEAE 39,240,1998
skin
human
10%/22 hour mild JIDEAE 11,474,1984
skin
human
2%/18 hour mild JIDEAE 92,693,1975
skin
human
3%/48 hour moderate JIDEAE 20,335,1989
skin
human
0.5%/24 hour JAADDB 30,944,1994
skin
human
0.1%/48 hour CODEDG 56,123,2007
skin
human
0.3%/3 week mild BJDEAZ 150,493,2004
skin
human
0.5%/4 day BJDEAZ 151,1039,2004
skin
mouse
25 mg/24 hour moderate JSCCA5 23,371,1972
skin
pig
25 mg/24 hour mild JSCCA5 23,371,1972
skin
rat
10%/1 hour TOXID9 66,161,2002
skin
rat
1%/4 hour TOXID9 66,162,2002
skin
rabbit
25 mg/24 hour moderate JSCCA5 23,371,1972
skin
rabbit
250 mg/24 hour moderate TXAPA9 31,481,1975
skin
rabbit
10 mg/24 hour moderate DCTODJ 1,305,1978
skin
rabbit
50 mg/24 hour mild TXAPA9 21,369,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage rat liver 243 µmol/L EMMUEG 24,181,1994
DNA inhibition guinea pig kidney 60 µmol/L FCTXAV 14,431,1976
DNA inhibition human lymphocyte 100 mg/L BECTA6 28,504,1982
DNA repair Escherichia coli 12,500 nL/well MUREAV 158,19,1985
mutation in microorganisms other microorganisms 200 mg/L (-enzymatic activation step) JDREAF 55,266,1976
mutation in microorganisms Saccharomyes cerevisiae 3,500 µmol/L (-enzymatic activation step) JOBAAY 115,461,1973
sex chromosome loss and nondisjunction Aspergillus nidulans 900 ppm MUREAV 142,179,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 480 mg/kg (6-13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TRENAF 27,113,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
mammal (species unspecified)
lowest published toxic dose: 3 pph Eye: Conjunctiva irritation TOXID9 44,409,2005
intraperitoneal
mouse
lethal dose (50 percent kill): 250 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Vascular: Regional or general arteriolar or venous dilation
JAPMA8 42,283,1953
intraperitoneal
rat
lethal dose (50 percent kill): 210 mg/kg N/R PSTGAW 3,1,1945
intravenous
mouse
lethal dose (50 percent kill): 118 mg/kg N/R JPMSAE 52,803,1963
intravenous
rat
lethal dose (50 percent kill): 118 mg/kg N/R JPMSAE 52,803,1963
oral
rat
lethal dose (50 percent kill): 1,288 mg/kg N/R FCTXAV 5,763,1967
skin
human
lowest published toxic dose: 0.14 mg/kg/24 hour Skin: After topical application: Primary irritation IJCMDW 22,73,2000
skin
human
lowest published toxic dose: 1 pph/24 hour Skin: After topical application: Primary irritation TOXID9 44,451,2005
skin
mouse
lowest published toxic dose: 200 mg/kg Skin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 182,126,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 75 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JJATDK 7,213,1987
oral
rat
lowest published toxic dose: 22,750 mg/kg/13 week- continuous Liver: Changes in liver weight FCTXAV 5,763,1967
skin
human
lowest published toxic dose: 0.45 mg/kg/3 week- intermittent Skin: After topical application: Primary irritation CODEDG 42,264,2000
skin
human
lowest published toxic dose: 0.1 pph/3 week- intermittent Skin: After topical application: Primary irritation TOXID9 44,451,2005
skin
mouse
lowest published toxic dose: 150 mg/kg/3 day- intermittent Immunological Including Allergic: Decrease in cellular immune response ETOPFR 17,95,2004
skin
mouse
lowest published toxic dose: 52.5 mg/kg/3 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Increase in humoral response
TXCYAC 206,285,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ARTODN 32,245,1974
TOXICOLOGY REVIEW
MUREAV 658,124,2008
TOXICOLOGY REVIEW
HUTOX* -,683,1996
TOXICOLOGY REVIEW
HUTOX* -,683,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,323,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81990;
Number of Industries 167;
Total Number of Facilities 32,028;
Number of Occupations 113;
Total Number of Employees Exposed 388,848
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81990;
Number of Industries 232;
Total Number of Facilities 46,312;
Number of Occupations 170;
Total Number of Employees Exposed 886,968;
Total Number of Female Employees Exposed 415,360


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an oil dispersant, and as a cosmetic and perfume ingredient
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8800
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTOX*
IJCMDW International Journal of Cosmetic Science. (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1979-
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PSTGAW Proceedings of the Scientific Section of the Toilet Goods Association. (Washington, DC) No.1-48, 1944-67. Discontinued.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as an oil dispersant, and as a cosmetic and perfume ingredient

FDA-over the counter drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

ALT CAS #: 51222-39-0
Click Here for Additional Information about RTECS

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