Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Sulfuric acid, monododecyl ester, sodium salt

RTECS #

WT1050000

CAS #

151-21-3; 51222-39-0

Updated

December 2013

Molecular Weight

288.42

Molecular Formula

C12H25O4S·Na

Synonyms

AI3-00356
Akyposal SDS
Aquarex ME
Aquarex methyl
Avirol 101
Avirol 118 conc
Berol 452
Carsonol SLS
Carsonol SLS Paste B
Carsonol SLS Special
Conco sulfate WA
Conco sulfate WA-1200
Conco sulfate WA-1245
Conco Sulfate WAG
Conco Sulfate WAN
Conco Sulfate WAS
Conco sulfate WN
CP 75424
Cycloryl 21
Cycloryl 31
Cycloryl 580
Cycloryl 585N
Dehydag sulfate GL emulsion
Dehydag sulphate GL emulsion
Detergent 66
Dodecyl alcohol, hydrogen sulfate, sodium salt
Dodecyl sodium sulfate
Dodecyl sulfate sodium
Dodecyl sulfate, sodium salt
Dreft
Duponal
Duponal WAQE
Duponol
Duponol C
Duponol ME
Duponol methyl
Duponol QX
Duponol WA
Duponol WA Dry
Duponol WAQ
Duponol WAQA
Duponol WAQE
Duponol WAQM
EMAL 10
EMAL O
Emersal 6400
Empicol LPZ
Empicol LS 30
Empicol LX 28
Emulsifier No. 104
Finasol osr(sub 2)
Gardinol
Hexamol SLS
Incronol SLS
Irium
Jordanol SL-300
Lanette wax-S
Lauryl sodium sulfate
Lauryl sulfate, sodium salt
Laurylsiran sodny (Czech)
Maprofix 563
Maprofix LK
Maprofix NEU
Maprofix WAC
Maprofix wac-LA
Melanol CL
Melanol CL 30
Monododecyl sodium sulfate
Monogen Y 100
Montopol LA paste
NCI-C50191
n-Dodecyl sulfate sodium
Neutrazyme
Nikkol SLS
Odoripon AL 95
Orvus WA paste
P and G emulsifier 104
Perlandrol L
Product No. 161
Product No. 75
Quolac EX-UB
Rewopol NLS 30
Richonol A
Richonol AF
Richonol C
SDS
Sinnopon LS 100
Sinnopon LS 95
Sintapon L
Sipex OP
Sipex SB
Sipex SD
Sipex SP
Sipex UB
Sipon LS
Sipon LS 100
Sipon LSB
Sipon PD
Sipon WD
SLS
Sodium dodecyl sulfate
Sodium dodecyl sulphate
Sodium lauryl sulfate
Sodium lauryl sulphate
Sodium monododecyl sulfate
Sodium monolauryl sulfate
Sodium n-dodecyl sulfate
Solsol needles
Standapol 112 conc
Standapol WA-AC
Standapol WAQ
Standapol WAQ Special
Standapol WAS 100
Steinapol NLS 90
Stepanol ME
Stepanol ME Dry
Stepanol ME Dry AW
Stepanol methyl
Stepanol methyl dry AW
Stepanol T 28
Stepanol WA
Stepanol WA paste
Stepanol WA-100
Stepanol WAC
Stepanol WAQ
Sterling WA paste
Sterling WAQ-CH
Sterling waq-cosmetic
Sulfetal L 95
Sulfopon WA 1
Sulfopon WA 1 special
Sulfopon WA 2
Sulfopon WA 3
Sulfotex WA
Sulfotex WALA
Swascol 1P
Swascol 3L
Swascol 4L
Syntapon
Syntapon L
Syntapon L pasta (Czech)
Tarapon K 12
Texapon DL conc.
Texapon K12
Texapon K-1296
Texapon L 100
Texapon V HC
Texapon V HC powder
Texapon Z high conc. needles
Texapon ZHC
Trepenol WA
TVM 474
Ultra sulfate SL-1
WAQE
Witcolate A
Witcolate A powder
Witcolate C

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate28ZPAK -,305,1972
eye /rabbit 250 µg mildAROPAW 34,99,1945
eye /rabbit 2 mgDCTODJ 1,305,1978
eye /rabbit 10 mg moderateTXAPA9 55,501,1980
skin /Dog 25 mg/24H mildJSCCA5 23,371,1972
skin /guinea pig 25 mg/24H mildJSCCA5 23,371,1972
skin /human 0.06%/24H mildJIDEAE 10,159,1995
skin /human 0.1%/24H moderateJIDEAE 76,341,1996
skin /human 0.5%/23HJIDEAE 76,450,1996
skin /human 0.5%/47H mildJIDEAE 39,240,1998
skin /human 10%/22H mildJIDEAE 11,474,1984
skin /human 2%/18H mildJIDEAE 92,693,1975
skin /human 3%/48H moderateJIDEAE 20,335,1989
skin /human 0.5%/24HJAADDB 30,944,1994
skin /human 0.1%/48HCODEDG 56,123,2007
skin /human 0.3%/3W mildBJDEAZ 150,493,2004
skin /human 0.5%/4DBJDEAZ 151,1039,2004
skin /human 0.1%/3W- intermittentTOXID9 44,451,2005
skin /human 2%/2H mildBCLPT* 103,461,2008
skin /human 0.25%CODEDG 61,209,2009
skin /human 250 mg/24H mildTXAPA9 31,481,1975
skin /human 25 mg/24H mildJSCCA5 23,371,1972
skin /mouse 25 mg/24H moderateJSCCA5 23,371,1972
skin /pig 25 mg/24H mildJSCCA5 23,371,1972
skin /rabbit 25 mg/24H moderateJSCCA5 23,371,1972
skin /rabbit 250 mg/24H moderateTXAPA9 31,481,1975
skin /rabbit 10 mg/24HDCTODJ 1,305,1978
skin /rabbit 50 mg/24H mildTXAPA9 21,369,1972
skin /rat 10%/1HTOXID9 66,161,2002
skin /rat 1%/4HTOXID9 66,162,2002

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageliver/rat243 µmol/LEMMUEG 24,181,1994
DNA inhibitionkidney/guinea pig60 µmol/LFCTXAV 14,431,1976
DNA inhibitionlymphocyte/human100 mg/LBECTA6 28,504,1982
DNA repair/Escherichia coli12500 nL/wellMUREAV 158,19,1985
mutation in microorganisms/Other microorganisms200 mg/L (-enzymatic activation step)JDREAF 55,266,1976
mutation in microorganisms/Saccharomyes cerevisiae3500 µmol/L (-enzymatic activation step)JOBAAY 115,461,1973
sex chromosome loss and nondisjunction/Aspergillus nidulans900 ppmMUREAV 142,179,1985

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
skin/mouse 480 mg/kg (6-13D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TRENAF 27,113,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
eye/mammal (species unspecified) lowest published toxic dose: 3 pphEye: Conjunctiva irritationTOXID9 44,409,2005
In Vitro/Hamster, lung fibroblast Inhibitor Concentration (50 percent kill): 61 mg/L/72HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 4,175,1990
In Vitro/Hamster, ovary Inhibitor Concentration Low: 0.02 mmol/L/30MIn Vitro Toxicity Studies: Cell countingTIVIEQ 2,65,1988
In Vitro/Human, endocrine tumor Inhibitor Concentration (99 percent kill): 6 mg/L/3DIn Vitro Toxicity Studies: Cell countingTIVIEQ 1,91,1987
In Vitro/Human, fibroblast Inhibitor Concentration (50 percent kill): 0.012 pph/48HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.
JOETD7 134,443,2011
In Vitro/Human, fibroblast Inhibitor Concentration Low: 0.009 pph/48HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.JOETD7 134,443,2011
In Vitro/Human, fibroblast Inhibitor Concentration Low: 0.010 pph/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.JOETD7 134,443,2011
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 0.018 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 40.79 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
In Vitro/Human, monocyte Inhibitor Concentration Low: >12.5 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TXAPA9 245,211,2010
In Vitro/Human, monocyte Inhibitor Concentration (50 percent kill): 18 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TXAPA9 245,211,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 1.8 µmol/L/4MIn Vitro Toxicity Studies: Membrane currentsTXAPA9 245,191,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration (50 percent kill): 11 µmol/L/15MIn Vitro Toxicity Studies: Other assaysTXAPA9 245,191,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration (20 percent kill): 85 µmol/L/30MIn Vitro Toxicity Studies: Other assaysTXAPA9 245,191,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration (50 percent kill): 200 µmol/L/60MBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 245,191,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration (50 percent kill): 240 µmol/L/30MIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TXAPA9 245,191,2010
In Vitro/Human, skin Inhibitor Concentration Low: 0.002 pph/48HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.JOETD7 134,443,2011
In Vitro/Human, skin Inhibitor Concentration Low: 0.001 pph/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.JOETD7 134,443,2011
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 0.006 pph/48HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.JOETD7 134,443,2011
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 0.007 pph/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.JOETD7 134,443,2011
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 69.6 mg/L/4HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,381,1993
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 63.5 mg/L/4HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,381,1993
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 34 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 17,717,2003
In Vitro/Mouse, macrophage Inhibitor Concentration (50 percent kill): 185 mg/L/17HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 1,77,1987
In Vitro/Rabbit, ocular Inhibitor Concentration (50 percent kill): 0.0045 gm/L/10MIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,329,1989
intraperitoneal/mouse lethal dose (50 percent kill): 250 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Vascular: Regional or general arteriolar or venous dilation
JAPMA8 42,283,1953
intraperitoneal/rat lethal dose (50 percent kill): 210 mg/kgPSTGAW 3,1,1945
intravenous/mouse lethal dose (50 percent kill): 118 mg/kgJPMSAE 52,803,1963
intravenous/rat lethal dose (50 percent kill): 118 mg/kgJPMSAE 52,803,1963
oral/rat lethal dose (50 percent kill): 1288 mg/kgFCTXAV 5,763,1967
skin/human lowest published toxic dose: 0.014 mg/kg/24HSkin: After topical application: Primary irritationIJCMDW 22,73,2000
skin/mouse lowest published toxic dose: 200 mg/kgSkin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 182,126,2002
Tank with water/Lugworm lethal concentration (50 percent kill): 15.2 mg/L/48HAQUTO* 10,235,1987

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 75 mg/kg/3D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)JJATDK 7,213,1987
oral/rat lowest published toxic dose: 22750 mg/kg/13W- continuousLiver: Changes in liver weightFCTXAV 5,763,1967
skin/human lowest published toxic dose: 0.45 mg/kg/3W- intermittentSkin: After topical application: Primary irritationCODEDG 42,264,2000
skin/mouse lowest published toxic dose: 150 mg/kg/3D- intermittentImmunological Including Allergic: Decrease in cellular immune responseETOPFR 17,95,2004
skin/mouse lowest published toxic dose: 52.5 mg/kg/3D- intermittentImmunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Increase in humoral response
TXCYAC 206,285,2005

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWARTODN 32,245,1974
TOXICOLOGY REVIEWMUREAV 658,124,2008
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWFEREAC 74,40503,2009
TOXICOLOGY REVIEWNTAPM* -,239,1995

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,323,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81990; Number of Industries 232; Total Number of Facilities 46312; Number of Occupations 170; Total Number of Employees Exposed 886968; Total Number of Female Employees Exposed 415360
National Occupational Hazard Survey 1974Hazard Code 81990; Number of Industries 167; Total Number of Facilities 32028; Number of Occupations 113; Total Number of Employees Exposed 388848

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8800
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP