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Sulfuric acid, diethyl ester

RTECS #: WS7875000

CAS #: 64-67-5


UPDATE: February 2009 MW: 154.20 MF: C4H10O4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Diaethylsulfat (German)
  2. Diethylester kyseliny sirove (Czech)
  3. Diethyl sulfate
  1. Diethyl sulphate
  2. Diethyl tetraoxosulfate
  3. Ethyl sulfate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg open irritation test mild UCDS** 12/30/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 1,297 Ámol/L MUTAEX 4,432,1989
cytogenetic analysis human lymphocyte 300 Ámol/L MUREAV 205,409,1988
cytogenetic analysis intraperitoneal
mouse
150 mg/kg MUREAV 75,63,1980
dominant lethal test intraperitoneal
mouse
100 mg/kg/10 week- intermittent GNKAA5 12(3),163,1976
dominant lethal test parenteral
mouse
150 mg/kg 28QFAD -,97,1973
dominant lethal test unreported route
mouse
150 mg/kg SOGEBZ 10,1004,1974
dominant lethal test parenteral
silkworm
100 Ámol/kg NISZAQ 46,205,1977
DNA adduct Escherichia coli 5 Ámol/L MUREAV 89,95,1981
DNA adduct mammal (species unspecified) lymphocyte 100 mmol/L BIJOAK 80,496,1961
DNA adduct mouse Ascites tumor 5 Ámol/L MUREAV 89,95,1981
DNA damage hamster ovary 2,500 Ámol/L MUREAV 92,361,1982
DNA damage human HeLa cell 20 mg BICHAW 14,1795,1975
DNA damage human mammary gland 21 mg/L/24 hour (-enzymatic activation step) MUREAV 588,47,2005
DNA damage intraperitoneal
mouse
250 mg/kg MUREAV 467,83,2000
DNA damage other microorganisms 9 gm/L CRNGDP 2,363,1981
DNA damage intraperitoneal
rat
39 mg/kg TCMUD8 7,175,1987
DNA damage Saccharomyes cerevisiae 590 mg/L/17 hour MUREAV 633,80,2007
DNA inhibition human HeLa cell 600 Ámol/L MUREAV 92,427,1982
DNA inhibition intraperitoneal
mouse
200 mg/kg MUREAV 46,305,1977
unscheduled DNA synthesis rat liver 100 Ámol/L ENMUDM 3,11,1981
host-mediated assay mouse
Salmonella typhimurium
2,500 Ámol/kg CBINA8 19,241,1977
mutation in microorganisms Aspergillus nidulans 50 mmol/L (-enzymatic activation step) RBGED3 9,393,1986
mutation in microorganisms Bacillus subtilis 5 mmol/L (-enzymatic activation step) EXPEAM 39,530,1983
mutation in microorganisms Escherichia coli 10 mmol/L (-enzymatic activation step) JOBAAY 79,464,1960
mutation in microorganisms Neurospora crassa 5,000 ppm/40 minute (-enzymatic activation step) GENTAE 63,281,1969
mutation in microorganisms other microorganisms 3,500 mg/L (-enzymatic activation step) PHABDI 18,165,1978
mutation in microorganisms Salmonella typhimurium 1 ÁL/plate (+enzymatic activation step) MUREAV 130,79,1984
mutation in microorganisms Salmonella typhimurium 5 mg/plate (-enzymatic activation step) MUREAV 57,141,1978
mutation in microorganisms Saccharomyes cerevisiae 5,000 ppm/15 minute (-enzymatic activation step) GENTAE 78,1101,1974
mutation in microorganisms Serratia marcescens 2 gm/L (-enzymatic activation step) ATXKA8 28,93,1971
mutation in microorganisms Schizosaccharomyces pombe 15,300 Ámol/L (-enzymatic activation step) CBINA8 14,195,1976
micronucleus test hamster lymphocyte 1 mmol/L MUREAV 205,409,1988
micronucleus test hamster lung 250 Ámol/L MUREAV 205,409,1988
micronucleus test hamster ovary 6 mmol/L/2 hour MUTAEX 18,405,2003
micronucleus test hamster fibroblast 6 mmol/L/2 hour MUTAEX 18,405,2003
micronucleus test hamster ovary 385 mg/L/24 hour MUREAV 633,80,2007
micronucleus test intraperitoneal
mouse
16 mg/kg/48 hour- intermittent MUREAV 389,3,1997
micronucleus test multiple
non-mammalian species
6 ppm/6 day- continuous MUREAV 164,245,1986
gene conversion and mitotic recombination Saccharomyes cerevisiae 20 mmol/L ZEVBA5 98,230,1966
mutation in mammalian somatic cells hamster ovary 1 mmol/L MUREAV 57,217,1978
mutation in mammalian somatic cells hamster lung 1 mg/L/1 hour CRNGDP 1,175,1980
other mutation test systems Escherichia coli 30 nmol/tube PNASA6 79,5971,1982
other mutation test systems Salmonella typhimurium 200 Ág/L MUREAV 192,239,1987
phage inhibition capacity Escherichia coli 65 mmol/L/20 minute PRLBA4 150,497,1959
sister chromatid exchange hamster lung 1 gm/L CNREA8 44,3270,1984
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
1,000 ppm/24 hour MUREAV 143,219,1985
sex chromosome loss and nondisjunction multiple
Drosophila melanogaster
5,000 ppm MUREAV 110,49,1983
sex chromosome loss and nondisjunction human lymphocyte 100 Ámol/L MUREAV 205,409,1988
specific locus test oral
Drosophila melanogaster
10 mmol/L MUREAV 182,243,1987
specific locus test oral
Drosophila melanogaster
10 mmol/L/3 hour MUREAV 545,59,2004
specific locus test intraperitoneal
mouse
100 mg/kg/10 week MUREAV 75,63,1980
specific locus test parenteral
silkworm
30 ng/kg KIKNAJ (25),42,1974
heritable translocation test multiple
Drosophila melanogaster
5,000 ppm/3.5 hour- continuous MUREAV 45,355,1977


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
rat
lowest published toxic dose: 340 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death IARCCD 4,45,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
rat
lowest published toxic dose: 85 mg/kg (15 day pregnant) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Brain and Coverings: Tumors
IARCCD 4,45,1973
oral
rat
lowest published toxic dose: 3,700 mg/kg/81 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
ZEKBAI 74,241,1970
subcutaneous
rat
lowest published toxic dose: 800 mg/kg/32 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
ZEKBAI 74,241,1970


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 250 ppm/4 hour N/R JIHTAB 31,343,1949
oral
mouse
lethal dose (50 percent kill): 647 mg/kg N/R NTIS** PB214-270
oral
rat
lethal dose (50 percent kill): 880 mg/kg N/R JIHTAB 31,60,1949
subcutaneous
rat
lethal dose (50 percent kill): 350 mg/kg N/R ZEKBAI 74,241,1970
skin
rabbit
lethal dose (50 percent kill): 600 ÁL/kg N/R UCDS** 12/30/1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 4,277,1974
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 54,213,1992
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1405,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMSUDL 7,198,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 54,213,1992
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,1405,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 71,1405,1999
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 613,17,2006
TOXICOLOGY REVIEW
MUTAEX 20,389,2005
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
MUTAEX 20,389,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA TRK 0.2 mg/m3 (0.03 mL/m3), JAN 2006
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY ceiling concentration 0.2 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 ppm (0.32 mg/m3), skin, JAN2002
Occupational Exposure Limit - SWEDEN Group B Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.03 ppm (0.2 mg/m3), Carcinogen, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.05 ppm (0.32 mg/m3) (skin), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84284;
Number of Industries 4;
Total Number of Facilities 116;
Number of Occupations 11;
Total Number of Employees Exposed 1,646
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84284;
Number of Industries 4;
Total Number of Facilities 86;
Number of Occupations 3;
Total Number of Employees Exposed 2,260;
Total Number of Female Employees Exposed 165


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Aspergillus-forward mutation; Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; N crassa-reversion
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion; S pombe-reversion
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Cytogenetics-male germ cell; Mouse specific locus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as an industrial chemical
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264) V.1- 1916-
GNKAA5 Genetika (Moscow). For English translation, see SOGEBZ. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1965-
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher information, see IAPUDO.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916-
KIKNAJ Kokuritsu Idengaku Kenkyusho Nenpo. Annual Report of the National Institute of Genetics. (Kokuritsu Idengaku Kenkyusho, 1111 Yata, Mishima, Shizuoka-ken 411, Japan) No. 1- 1949-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NISZAQ Nippon Sanshigaku Zasshi. Journal of Sericultural Science of Japan. (Nippon Sanshi Gakkai, 1-2 Owashi, Yatabe-machi, Tsukuba-gun, Ibaraki-ken, Japan) V.1- 1930-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PHABDI Proceedings of the Hungarian Annual Meeting for Biochemistry. (Magyar Kemikusok Egyesulete, Anker Koz 1, 1061 Budapest, Hungary) V.1- 1961-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
PRLBA4 Proceedings of the Royal Society of London, Series B: Biological Sciences. (Royal Soc., 6 Carlton House Terrace, London SW1Y 5AG, UK) V.76- 1905-
RBGED3 Revista Brasileira de Genetica. Brazilian Journal of Genetics. (Dr. F.A. Moura Duarte, Dep. de Genetica, Faculdade de Medicina de Ribeirao Preto, 14.100 Ribeirao Preto, Sao Paulo, Brazil) V.1- 1978-
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7.
ZEVBA5 Zeitschrift fuer Vererbungslehre. (Berlin, Fed. Rep. Ger.) V.89-98, 1958-66. For publisher information, see MGGEAE.

Used as an industrial chemical

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 98503-29-8
Click Here for Additional Information about RTECS

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