Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Succinic anhydride

RTECS #

WN0875000

CAS #

108-30-5

Updated

February 2008

Molecular Weight

100.08

Molecular Formula

C4H4O3

Synonyms

2,5-Diketotetrahydrofuran
2,5-Furandione, dihydro-
Bernsteinsaure-anhydrid (German)
Butanedioic anhydride
Dihydro-2,5-furandione
NCI-C55696
Rikacid SA
Succinic acid anhydride
Succinyl anhydride
Succinyl oxide
Tetrahydro-2,5-dioxofuran
Tetrahydro-2,5-furandione

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 750 µg severeAJOPAA 29,1363,1946

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformembryo/hamster100 µg/LIJCNAW 19,642,1977
morphological transformfibroblast/mouse1 mg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in microorganisms/Escherichia coli2 gm/L (-enzymatic activation step)MUREAV 130,97,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 79 mg/kg (8-10D pregnant)Reproductive: Other developmental abnormalitiesTCMUD8 2,61,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat lowest published toxic dose: 2600 mg/kg/65W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
BJCAAI 19,392,1965

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): 1510 mg/kgEPASR* 8EHQ-0282-0433

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 10500 mg/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-373,1990
oral/mouse lowest published toxic dose: 19500 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-373,1990
oral/rat lowest published toxic dose: 13 gm/kg/13W- intermittentLiver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-373,1990
oral/rat lowest published toxic dose: 2618 mg/kg/20D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-373,1990

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 15,265,1977
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 15,265,1977
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWMUREAV 584,1,2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4008; Number of Industries 7; Total Number of Facilities 263; Number of Occupations 5; Total Number of Employees Exposed 3059; Total Number of Female Employees Exposed 1207

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; L5178Y cells in vitro-TK test
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat
TOP