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Registry of Toxic Effects of Chemical Substances (RTECS)

Styrene, p-methyl-

RTECS #

WL5076000

CAS #

622-97-9

Updated

July 2013

Molecular Weight

118.19

Molecular Formula

C9H10

Synonyms

1-Ethenyl-4-methylbenzene
1-Methyl-4-vinylbenzene
1-p-Tolylethene
4-Methylstyrene
4-Vinyltoluene
Benzene, 1-ethenyl-4-methyl- (9CI)
p-Methylstyrene
p-Vinyltoluene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human330 µmol/LCRNGDP 2,237,1981
sister chromatid exchangelymphocyte/human330 µmol/LCRNGDP 2,237,1981

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 49000 mg/kg (multigeneration)Reproductive: Other effects on male

Reproductive: Other effects on female

Reproductive: Effects on newborn: Stillbirth
HPV129 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 3500 ppm/4HBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
HPV129 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 581 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
ATDAEI 1,76,1990
intraperitoneal/rat lethal dose (50 percent kill): 2324 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
ATDAEI 1,77,1990
intravenous/mouse lethal dose (50 percent kill): 280 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
ATDAEI 1,76,1990
intravenous/mouse lethal dose (50 percent kill): 308.7 mg/kgBehavioral: Somnolence (general depressed activity)HPV129 -,-,2001
intravenous/rat lowest published lethal dose: 562 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes
HPV129 -,-,2001
oral/Dog lethal dose (50 percent kill): >5 gm/kgHPV129 -,-,2001
oral/Dog lethal dose (50 percent kill): >5 gm/kgGastrointestinal: Nausea or vomiting

Gastrointestinal: Changes in structure or function of salivary glands

Behavioral: Tremor
ATDAEI 1,77,1990
oral/mouse lethal dose (50 percent kill): 1072 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
ATDAEI 1,76,1990
oral/mouse lethal dose (50 percent kill): 1072.2 mg/kgBehavioral: Ataxia

Gastrointestinal: Other changes
HPV129 -,-,2001
oral/mouse lethal dose (50 percent kill): 1150 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
HPV129 -,-,2001
oral/rat lethal dose (50 percent kill): 2255 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
ATDAEI 1,77,1990
oral/rat lethal dose (50 percent kill): 2523 mg/kgHPV325 -,-,2002
oral/rat lethal dose (50 percent kill): 2523 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Other changes
HPV129 -,-,2001
oral/rat lethal dose (50 percent kill): >4935 mg/kgBehavioral: Tremor

Liver: Other changes

Gastrointestinal: Other changes
HPV129 -,-,2001
skin/rabbit lethal dose (50 percent kill): >5 mL/kgSkin: After systemic exposure: Dermatitis, otherATDAEI 1,77,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1313 ppm/90D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV129 -,-,2001
oral/Dog lowest published toxic dose: 8400 mg/kg/28D- intermittentBehavioral: TremorHPV129 -,-,2001
oral/mouse lowest published toxic dose: 7000 mg/kg/28D- intermittentBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes
HPV129 -,-,2001
oral/rat lowest published toxic dose: 63000 mg/kg/90D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV129 -,-,2001
oral/rat lowest published toxic dose: 135000 mg/kg/90D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV129 -,-,2001
skin/rabbit lowest published toxic dose: 10.5 mL/kg/21D- intermittentSkin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV129 -,-,2001

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 60,373,1994
International Agency for Research on Cancer (IARC)Cancer Review:Animal LACK CARCINOGENICITYIMEMDT 60,373,1994
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 60,373,1994

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (246 mg/m3), short term exposure limit 100 ppm(490 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 25 ppm (120 mg/m3), MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 25 ppm (120 mg/m3), skin, NOV2011
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (240 mg/m3);short term exposure limit 100 ppm (485 mg/m3), 2004
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (240 mg/m3), KZG-week 100 ppm (480 mg/m3), JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2573; Number of Industries 7; Total Number of Facilities 460; Number of Occupations 10; Total Number of Employees Exposed 5274; Total Number of Female Employees Exposed 377

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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