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Styrene, p - methyl -

RTECS #: WL5076000

CAS #: 622-97-9


UPDATE: February 2009 MW: 118.19 MF: C9H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - Ethenyl - 4 - methylbenzene
  2. 1 - Methyl - 4 - vinylbenzene
  3. 1 - p - Tolylethene
  4. 4 - Methylstyrene
  1. 4 - Vinyltoluene
  2. Benzene, 1 - ethenyl - 4 - methyl - (9CI)
  3. p - Methylstyrene
  4. p - Vinyltoluene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 330 Ámol/L CRNGDP 2,237,1981
sister chromatid exchange human lymphocyte 330 Ámol/L CRNGDP 2,237,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 581 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
ATDAEI 1,76,1990
intraperitoneal
rat
lethal dose (50 percent kill): 2,324 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
ATDAEI 1,77,1990
intravenous
mouse
lethal dose (50 percent kill): 280 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
ATDAEI 1,76,1990
oral
dog
lethal dose (50 percent kill): >5 gm/kg Gastrointestinal: Nausea or vomiting

Gastrointestinal: Changes in structure or function of salivary glands

Behavioral: Tremor
ATDAEI 1,77,1990
oral
mouse
lethal dose (50 percent kill): 1,072 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
ATDAEI 1,76,1990
oral
rat
lethal dose (50 percent kill): 2,255 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
ATDAEI 1,77,1990
skin
rabbit
lethal dose (50 percent kill): >5 mL/kg Skin: After systemic exposure: Dermatitis, other ATDAEI 1,77,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,373,1994
International Agency for Research on Cancer (IARC) Cancer Review Animal LACK CARCINOGENICITY IMEMDT 60,373,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 60,373,1994


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (246 mg/m3), short term exposure limit 100 ppm(490 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (120 mg/m3), OCT 2002
Occupational Exposure Limit - GERMANY MAK 490 mg/m3 (100 mL/m3), 2005
Occupational Exposure Limit - MEXICO time-weighted average 50 ppm (240 mg/m3);
short term exposure limit 100 ppm (485 mg/m3), 2004
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (240 mg/m3),KZG- week 100 ppm (480 mg/m3), dayEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2573;
Number of Industries 7;
Total Number of Facilities 460;
Number of Occupations 10;
Total Number of Employees Exposed 5,274;
Total Number of Female Employees Exposed 377


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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