Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Strychnine, sulfate (2:1)

RTECS #

WL2550000

CAS #

60-41-3

Updated

August 2003

Molecular Weight

383.49

Molecular Formula

C21H22N2O2·1/2H2O4S

Synonyms

Antivampire
STrychinium sulfate
Strychnidin-10-one, sulfate (2:1) (9CI)
Strychnine hemisulfate
Strychnine sulfate
Vampirol

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/guinea pig lethal dose (50 percent kill): 10900 µg/kgBehavioral: Convulsions or effect on seizure thresholdAIPTAK 144,416,1963
intraperitoneal/mouse lethal dose (50 percent kill): 900 µg/kgIVEBBN 16,31,1977
intraperitoneal/rat lethal dose (50 percent kill): 1 mg/kgBehavioral: Convulsions or effect on seizure thresholdARZNAD 23,1125,1973
intraspinal/rat lowest published toxic dose: 83.33 µg/kgBrain and Coverings: Changes in surface EEG

Behavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests
JPETAB 296,756,2001
intravenous/cat lethal dose (50 percent kill): 2500 µg/kgPSEBAA 35,316,1936
intravenous/guinea pig lethal dose (50 percent kill): 390 µg/kgBehavioral: Convulsions or effect on seizure thresholdAIPTAK 144,416,1963
intravenous/mouse lethal dose (50 percent kill): 475 µg/kgJPETAB 79,127,1943
intravenous/rat lethal dose (50 percent kill): 570 µg/kgBehavioral: Convulsions or effect on seizure thresholdAIPTAK 144,416,1963
oral/child lowest published lethal dose: 3367 µg/kgBehavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Acute pulmonary edema
JFSCAS 30,1248,1985
oral/man lowest published lethal dose: 37 mg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Pleural thickening
JATOD3 10,120,1986
oral/mouse lowest published lethal dose: 8 mg/kgAECTCV 14,111,1985
oral/rat lethal dose (50 percent kill): 2600 µg/kgJAPMA8 31,113,1942
oral/wild bird lethal dose (50 percent kill): 5600 µg/kgTXAPA9 21,315,1972
oral/woman lowest published toxic dose: 6800 µg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Blood: Other changes
CMAJAX 124,1268,1981
subcutaneous/guinea pig lethal dose (50 percent kill): 4800 µg/kgBehavioral: Convulsions or effect on seizure thresholdAIPTAK 144,416,1963
subcutaneous/mouse lethal dose (50 percent kill): 1250 µg/kgJPETAB 67,153,1939
subcutaneous/rat lethal dose (50 percent kill): 1700 µg/kgTXAPA9 18,185,1971

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,278,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84661; Number of Industries 2; Total Number of Facilities 229; Number of Occupations 3; Total Number of Employees Exposed 1241; Total Number of Female Employees Exposed 690
National Occupational Hazard Survey 1974Hazard Code 84661; Number of Industries 2; Total Number of Facilities 872; Number of Occupations 7; Total Number of Employees Exposed 3575
TOP