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Strychnine, sulfate (2:1)

RTECS #: WL2550000

CAS #: 60-41-3


UPDATE: August 2003 MW: 383.49 MF: C21H22N2O21/2H2O4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. STANDARDS AND REGULATIONS:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. Antivampire
  2. STrychinium sulfate
  3. Strychnidin - 10 - one, sulfate (2:1) (9CI)
  1. Strychnine hemisulfate
  2. Strychnine sulfate
  3. Vampirol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
guinea pig
lethal dose (50 percent kill): 10,900 g/kg Behavioral: Convulsions or effect on seizure threshold AIPTAK 144,416,1963
intraperitoneal
mouse
lethal dose (50 percent kill): 900 g/kg N/R IVEBBN 16,31,1977
intraperitoneal
rat
lethal dose (50 percent kill): 1 mg/kg Behavioral: Convulsions or effect on seizure threshold ARZNAD 23,1125,1973
intraspinal
rat
lowest published toxic dose: 83.33 g/kg Brain and Coverings: Changes in surface EEG

Behavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests
JPETAB 296,756,2001
intravenous
cat
lethal dose (50 percent kill): 2,500 g/kg N/R PSEBAA 35,316,1936
intravenous
guinea pig
lethal dose (50 percent kill): 390 g/kg Behavioral: Convulsions or effect on seizure threshold AIPTAK 144,416,1963
intravenous
mouse
lethal dose (50 percent kill): 475 g/kg N/R JPETAB 79,127,1943
intravenous
rat
lethal dose (50 percent kill): 570 g/kg Behavioral: Convulsions or effect on seizure threshold AIPTAK 144,416,1963
oral
wild bird
lethal dose (50 percent kill): 5,600 g/kg N/R TXAPA9 21,315,1972
oral
child
lowest published lethal dose: 3,367 g/kg Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Acute pulmonary edema
JFSCAS 30,1248,1985
oral
man
lowest published lethal dose: 37 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Pleural thickening
JATOD3 10,120,1986
oral
mouse
lowest published lethal dose: 8 mg/kg N/R AECTCV 14,111,1985
oral
rat
lethal dose (50 percent kill): 2,600 g/kg N/R JAPMA8 31,113,1942
oral
woman
lowest published toxic dose: 6,800 g/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Blood: Other changes
CMAJAX 124,1268,1981
subcutaneous
guinea pig
lethal dose (50 percent kill): 4,800 g/kg Behavioral: Convulsions or effect on seizure threshold AIPTAK 144,416,1963
subcutaneous
mouse
lethal dose (50 percent kill): 1,250 g/kg N/R JPETAB 67,153,1939
subcutaneous
rat
lethal dose (50 percent kill): 1,700 g/kg N/R TXAPA9 18,185,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,278,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84661;
Number of Industries 2;
Total Number of Facilities 872;
Number of Occupations 7;
Total Number of Employees Exposed 3,575
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84661;
Number of Industries 2;
Total Number of Facilities 229;
Number of Occupations 3;
Total Number of Employees Exposed 1,241;
Total Number of Female Employees Exposed 690


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

N/R


REFERENCES:

CODEN
REFERENCE

AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IVEBBN International Journal for Vitamin and Nutrition Research, Supplement. (Verlag Hans Huber, Laenggastr. 76, CH-3000 Bern 9, Switzerland) No.12- 1972-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977-
JFSCAS Journal of Forensic Sciences. (American Soc. for Testing and Materials, 1916 Race St., Philadelphia, PA 19103) V.1- 1956-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used to kill gophers and moles

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Human Data

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