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Stearic acid

RTECS #: WI2800000

CAS #: 57-11-4


UPDATE: November 2007 MW: 284.54 MF: C18H36O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Heptadecanecarboxylic acid
  2. Century 1240
  3. Cetylacetic acid
  4. Dar - chem 14
  5. Emersol 120
  6. Emersol 132
  7. Emersol 150
  8. Formula 300
  9. Glycon DP
  10. Glycon S - 70
  11. Glycon S - 80
  12. Glycon S - 90
  13. Glycon TP
  14. Groco 54
  15. Groco 55
  16. Groco 55L
  17. Groco 58
  18. Groco 59
  19. HY - Phi 1199
  20. HY - Phi 1205
  21. HY - Phi 1303
  22. HY - Phi 1401
  23. Hydrofol 1895
  24. Hydrofol acid 1655
  25. Hydrofol acid 1855
  26. Hystrene 80
  1. Hystrene 4516
  2. Hystrene 5016
  3. Hystrene 7018
  4. Hystrene 9718
  5. Industrene 5016
  6. Industrene 8718
  7. Industrene 9018
  8. KAM 1000
  9. KAM 2000
  10. KAM 3000
  11. Neo - fat 18
  12. Neo - fat 18 - S
  13. Neo - fat 18 - 53
  14. Neo - fat 18 - 54
  15. Neo - fat 18 - 55
  16. Neo - fat 18 - 59
  17. Neo - fat 18 - 61
  18. Octadecanoic acid
  19. Pearl stearic
  20. Stearex beads
  21. Stearic acid (ACGIH)
  22. Stearophanic acid
  23. Tegostearic 254
  24. Tegostearic 255
  25. Tegostearic 272
  26. n - Octadecanoic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
human
75 mg/3 day- intermittent mild 85DKA8 -,127,1977
skin
rabbit
500 mg/24 hour moderate FCTXAV 17,383,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human liver 10 mg/L/20 hour MUREAV 577S,1,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
implant
mouse
lowest published toxic dose: 400 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
BJCAAI 17,127,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
mouse
lethal dose (50 percent kill): 23 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
APTOA6 18,141,1961
intravenous
rat
lethal dose (50 percent kill): 21,500 g/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
APTOA6 18,141,1961
oral
rat
lowest published lethal dose: 4,640 mg/kg N/R JACTDZ 6(3),321,1987
skin
rabbit
lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,383,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lowest published toxic dose: 31,500 mg/kg/30 week- continuous Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
IJTOFN 18,33,1999
oral
rat
lowest published toxic dose: 313 gm/kg/30 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JACTDZ 14,196,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
AMIHAB 21,100,1960
TOXICOLOGY REVIEW
MUREAV 531,25,2003
TOXICOLOGY REVIEW
IJTOFN 24,65,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 69740;
Number of Industries 220;
Total Number of Facilities 31,794;
Number of Occupations 159;
Total Number of Employees Exposed 541,742
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7032;
Number of Industries 3;
Total Number of Facilities 136;
Number of Occupations 11;
Total Number of Employees Exposed 9,034;
Total Number of Female Employees Exposed 7,670
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 69740;
Number of Industries 239;
Total Number of Facilities 34,970;
Number of Occupations 165;
Total Number of Employees Exposed 1,123,118;
Total Number of Female Employees Exposed 568,888


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in cosmetics, pharmaceuticals, rubber compounding and in production of stearate salts
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used in cosmetics, pharmaceuticals, rubber compounding and in production of stearate salts

NIOSH PROFILE (ACIDS, ORGANIC), SRI, 2/77

NIOSH PROFILE (ACIDS, ORGANIC), SRC, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Natural Product
   Primary Irritant

Click Here for Additional Information about RTECS

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