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Registry of Toxic Effects of Chemical Substances (RTECS)

Stearic acid

RTECS #

WI2800000

CAS #

57-11-4

Updated

August 2009

Molecular Weight

284.54

Molecular Formula

C18H36O2

Synonyms

1-Heptadecanecarboxylic acid
Century 1240
Cetylacetic acid
Dar-chem 14
Emersol 120
Emersol 132
Emersol 150
Formula 300
Glycon DP
Glycon S-70
Glycon S-80
Glycon S-90
Glycon TP
Groco 54
Groco 55
Groco 55L
Groco 58
Groco 59
Hydrofol 1895
Hydrofol acid 1655
Hydrofol acid 1855
HY-Phi 1199
HY-Phi 1205
HY-Phi 1303
HY-Phi 1401
Hystrene 4516
Hystrene 5016
Hystrene 7018
Hystrene 80
Hystrene 9718
Industrene 5016
Industrene 8718
Industrene 9018
KAM 1000
KAM 2000
KAM 3000
Neo-fat 18
Neo-fat 18-53
Neo-fat 18-54
Neo-fat 18-55
Neo-fat 18-59
Neo-fat 18-61
Neo-fat 18-S
n-Octadecanoic acid
Octadecanoic acid
Pearl stearic
Stearex beads
Stearic acid (ACGIH)
Stearophanic acid
Tegostearic 254
Tegostearic 255
Tegostearic 272

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 75 mg/3D- intermittent mild85DKA8 -,127,1977
skin /rabbit 500 mg/24H moderateFCTXAV 17,383,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageliver/human10 mg/L/20HMUREAV 577S,1,2005

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 400 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
BJCAAI 17,127,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/mouse lethal dose (50 percent kill): 23 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
APTOA6 18,141,1961
intravenous/rat lethal dose (50 percent kill): 21500 µg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
APTOA6 18,141,1961
oral/human lethal dose (50 percent kill): 14286 mg/kgHPV125 -,-,2005
oral/rat lethal dose (50 percent kill): 4600 mg/kgHPV125 -,-,2005
oral/rat lowest published lethal dose: 4640 mg/kgJACTDZ 6(3),321,1987
skin/rabbit lethal dose (50 percent kill): >5 gm/kgFCTXAV 17,383,1979

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 31500 mg/kg/30W- continuousBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
IJTOFN 18,33,1999
oral/mouse lowest published toxic dose: 252 gm/kg/3W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV125 -,-,2005
oral/mouse lowest published toxic dose: 1260 gm/kg/3W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV125 -,-,2005
oral/rat lowest published toxic dose: 313 gm/kg/30W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJACTDZ 14,196,1995
oral/rat lowest published toxic dose: 8400 gm/kg/24W- intermittentBiochemical: Metabolism (intermediary): Lipids including transportHPV125 -,-,2005
oral/rat lowest published toxic dose: 31500 mg/kg/30W- intermittentBehavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV125 -,-,2005
oral/rat lowest published toxic dose: 157.5 gm/kg/6W- intermittentBlood: Change in clotting factors

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
HPV125 -,-,2005

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWAMIHAB 21,100,1960
TOXICOLOGY REVIEWMUREAV 531,25,2003
TOXICOLOGY REVIEWIJTOFN 24,65,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7032; Number of Industries 3; Total Number of Facilities 136; Number of Occupations 11; Total Number of Employees Exposed 9034; Total Number of Female Employees Exposed 7670
National Occupational Exposure Survey 1983Hazard Code 69740; Number of Industries 239; Total Number of Facilities 34970; Number of Occupations 165; Total Number of Employees Exposed 1123118; Total Number of Female Employees Exposed 568888
National Occupational Hazard Survey 1974Hazard Code 69740; Number of Industries 220; Total Number of Facilities 31794; Number of Occupations 159; Total Number of Employees Exposed 541742

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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