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Registry of Toxic Effects of Chemical Substances (RTECS)

Stannane, hydroxytriphenyl-

RTECS #

WH8575000

CAS #

76-87-9

Updated

September 201

Molecular Weight

367.03

Molecular Formula

C18H16OSn

Synonyms

Dowco 186
Du-Ter
Du-Ter W-50
ENT 28009
Erithane
Fenolovo
Fentin hydroxide
Fintin hydroxid (German)
Fintin hydroxyde (Dutch)
Fintin idrossido (Italian)
Fintine hydroxyde (French)
Flo-Tin 4L
Haitin
Hydroxyde de triphenyl-etain (French)
Hydroxytriphenylstannane
Hydroxytriphenyltin
Idrossido di stagno trifenile (Italian)
K 19
NCI-C00260
OMS 1017
Phenostat-H
Sunitron H
Suzu H
Tin, hydroxytriphenyl-
TPTH
Tptoh
Trifenylstanniumhydroxid (Czech)
Trifenyl-tinhydroxyde (Dutch)
Triphenylstannium hydroxide
Triphenyltin hydroxide
Triphenyltin oxide
Triphenyl-zinnhydroxid (German)
Vancide KS

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /guinea pig 100%/2S rinse severeTXAPA9 14,628,1969
eye /rabbit 10 mgCTOXAO 13,281,1978
skin /human 0.5%/48HCODEDG 17,212,1987

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testoral/mouse2500 µg/kgMUREAV 444,167,1999
micronucleus testintraperitoneal/mouse2500 µg/kgMUREAV 444,167,1999
micronucleus testovary/hamster150 µg/LMUREAV 444,167,1999
morphological transformembryo/rat19 ng/plateJJATDK 1,190,1981
other mutation test systemsovary/hamster60 µg/LMUREAV 300,5,1993
sister chromatid exchangeovary/hamster25 µg/LMUREAV 444,167,1999

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 105 mg/kg (8-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)CTOXAO 13,281,1978
oral/rat 140 mg/kg (1-7D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)CTOXAO 13,281,1978
oral/rat 140 mg/kg (1-7D pregnant)Reproductive: Effects on fertility: Other measures of fertilityTOANDB 3,281,1979
oral/rat 130 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TJADAB 42,651,1990
oral/mouse 180 mg/kg (6-17D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
RTOPDW 49,43,2007
oral/mouse 45 mg/kg (6-17D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemRTOPDW 49,43,2007
oral/mouse 90 mg/kg (6-17D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Urogenital system
RTOPDW 49,43,2007

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 0.01 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 0.04 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 0.03 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 0.06 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 2,1,1988
inhalation/rat lethal concentration (50 percent kill): 60 mg/m3HBPTO* 2,1216,2001
intraperitoneal/guinea pig lethal dose (50 percent kill): 3740 µg/kgBJIMAG 23,222,1966
intraperitoneal/mouse lowest published lethal dose: 8500 µg/kgTXAPA9 23,288,1972
intraperitoneal/rat lowest published lethal dose: 100 mg/kgNCNSA6 5,46,1953
intravenous/rabbit lowest published lethal dose: 25 mg/kgEye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
CTOXAO 13,281,1978
oral/guinea pig lethal dose (50 percent kill): 27 mg/kgHBPTO* 2,1216,2001
oral/mouse lethal dose (50 percent kill): 209 mg/kgYKYUA6 30,505,1979
oral/rat lethal dose (50 percent kill): 46 mg/kgNCILB* NCI-E-C-72-3252,1973
skin/rabbit lethal dose (50 percent kill): 1600 mg/kgHBPTO* 2,1216,2001
skin/rat lethal dose (50 percent kill): 1600 mg/kgHBPTO* 2,1216,2001
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 500 mg/kg30ZDA9 -,302,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2 mg/m3/13W- continuousLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Luekopenia
HBPTO* 2,1221,2001
inhalation/rat lowest published toxic concentration: 2 mg/m3/13W- continuousLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Luekopenia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1221,2001
intraperitoneal/mouse lowest published toxic dose: 30 µg/kg/5D- intermittentEndocrine: Change in LH

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOLED5 166,53,2006
intraperitoneal/mouse lowest published toxic dose: 75 µg/kg/5D- intermittentReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
TOLED5 166,53,2006
oral/Dog lowest published toxic dose: 92500 µg/kg/14W- continuousBehavioral: Somnolence (general depressed activity)RREVAH 79,1,1981
oral/domestic animal lowest published toxic dose: 42 mg/kg/70D- continuousEndocrine: Other changes

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1221,2001
oral/guinea pig lowest published toxic dose: 13500 µg/kg/90D- continuousBlood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count
FCTXAV 4,35,1966
oral/mouse lowest published toxic dose: 182.2 mg/kg/2Y- continuousBlood: LuekopeniaHBPTO* 2,1221,2001
oral/rabbit lowest published toxic dose: 31.5 mg/kg/70D- continuousEndocrine: Other changes

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1221,2001
oral/rat lowest published toxic dose: 20 mg/kg/20D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
RREVAH 79,1,1981
oral/rat lowest published toxic dose: 500 mg/kg/25D- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)HBPTO* 2,1222,2001
oral/rat lowest published toxic dose: 1350 mg/kg/90D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldCTOXAO 13,281,1978

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg(Sn)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-short term exposure limit 0.2 mg(Sn)/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWEQSFAP 4,80,1975
TOXICOLOGY REVIEWCRTXB2 34,301,2004
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,281,2004
TOXICOLOGY REVIEWFEREAC 72,41913,2007
TOXICOLOGY REVIEWREPTED 27,8,2009
TOXICOLOGY REVIEWMUTAEX 23,271,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,151,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 mg(Sn)/m3DTLVS* 3,258,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit-FRANCEVME 0.1 mg(Sn)/m3, VLE 0.2 mg(Sn)/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.0004 ppm (0.002 mg/m3), inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.4 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg(Sn)/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.002 mg(Sn)/m3, KZG-week 0.004 mg(Sn)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Sn)/m3;short term exposure limit 0.2 mg(Sn)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air10H time-weighted average 0.1 mg(Sn)/m3NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-139,1978
On EPA IRIS database
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