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Stannane, hydroxytriphenyl -

RTECS #: WH8575000

CAS #: 76-87-9


UPDATE: May 2009 MW: 367.03 MF: C18H16OSn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Dowco 186
  2. Du - Ter
  3. Du - Ter W - 50
  4. ENT 28009
  5. Erithane
  6. Fenolovo
  7. Fentin hydroxide
  8. Fintin hydroxid (German)
  9. Fintin hydroxyde (Dutch)
  10. Fintin idrossido (Italian)
  11. Fintine hydroxyde (French)
  12. Flo - Tin 4L
  13. Haitin
  14. Hydroxyde de triphenyl - etain (French)
  15. Hydroxytriphenylstannane
  16. Hydroxytriphenyltin
  17. Idrossido di stagno trifenile (Italian)
  1. K 19
  2. NCI - C00260
  3. OMS 1017
  4. Phenostat - H
  5. Sunitron H
  6. Suzu H
  7. TPTH
  8. Tin, hydroxytriphenyl -
  9. Tptoh
  10. Trifenylstanniumhydroxid (Czech)
  11. Trifenyl - tinhydroxyde (Dutch)
  12. Triphenylstannium hydroxide
  13. Triphenyltin hydroxide
  14. Triphenyltin oxide
  15. Triphenyl - zinnhydroxid (German)
  16. Vancide KS


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
guinea pig
1,00%/2S rinse severe TXAPA9 14,628,1969
eye
rabbit
10 mg severe CTOXAO 13,281,1978
skin
human
0.5 %/48 hour CODEDG 17,212,1987


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
micronucleus test hamster ovary 150 g/L MUREAV 444,167,1999
micronucleus test oral
mouse
2,500 g/kg MUREAV 444,167,1999
micronucleus test intraperitoneal
mouse
2,500 g/kg MUREAV 444,167,1999
morphological transform rat embryo 19 ng/plate JJATDK 1,190,1981
other mutation test systems hamster ovary 60 g/L MUREAV 300,5,1993
sister chromatid exchange hamster ovary 25 g/L MUREAV 444,167,1999


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 105 mg/kg (8-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) CTOXAO 13,281,1978
oral
rat
lowest published toxic dose: 140 mg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) CTOXAO 13,281,1978
oral
rat
lowest published toxic dose: 140 mg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Other measures of fertility TOANDB 3,281,1979
oral
rat
lowest published toxic dose: 130 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 42,651,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 60 mg/m3 N/R HBPTO* 2,1216,2001
intraperitoneal
guinea pig
lethal dose (50 percent kill): 3,740 g/kg N/R BJIMAG 23,222,1966
intraperitoneal
mouse
lowest published lethal dose: 8,500 g/kg N/R TXAPA9 23,288,1972
intraperitoneal
rat
lowest published lethal dose: 100 mg/kg N/R NCNSA6 5,46,1953
intravenous
rabbit
lowest published lethal dose: 25 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
CTOXAO 13,281,1978
oral
guinea pig
lethal dose (50 percent kill): 27 mg/kg N/R HBPTO* 2,1216,2001
oral
mouse
lethal dose (50 percent kill): 209 mg/kg N/R YKYUA6 30,505,1979
oral
rat
lethal dose (50 percent kill): 46 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
skin
rat
lethal dose (50 percent kill): 1,600 mg/kg N/R HBPTO* 2,1216,2001
skin
rabbit
lethal dose (50 percent kill): 1,600 mg/kg N/R HBPTO* 2,1216,2001
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 500 mg/kg N/R 30ZDA9 -,302,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 2 mg/m3/13 week- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Luekopenia
HBPTO* 2,1221,2001
inhalation
rat
lowest published toxic concentration: 2 mg/m3/13 week- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Luekopenia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1221,2001
intraperitoneal
mouse
lowest published toxic dose: 30 g/kg/5 day- intermittent Endocrine: Change in LH

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOLED5 166,53,2006
intraperitoneal
mouse
lowest published toxic dose: 75 g/kg/5 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
TOLED5 166,53,2006
oral
dog
lowest published toxic dose: 92,500 g/kg/14 week- continuous Behavioral: Somnolence (general depressed activity) RREVAH 79,1,1981
oral
domestic animal
lowest published toxic dose: 42 mg/kg/70 day- continuous Endocrine: Other changes

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1221,2001
oral
guinea pig
lowest published toxic dose: 13,500 g/kg/90 day- continuous Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count
FCTXAV 4,35,1966
oral
mouse
lowest published toxic dose: 182.2 mg/kg/2 year- continuous Blood: Luekopenia HBPTO* 2,1221,2001
oral
rat
lowest published toxic dose: 1,350 mg/kg/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field CTOXAO 13,281,1978
oral
rat
lowest published toxic dose: 20 mg/kg/20 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
RREVAH 79,1,1981
oral
rat
lowest published toxic dose: 500 mg/kg/25 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) HBPTO* 2,1222,2001
oral
rabbit
lowest published toxic dose: 31.5 mg/kg/70 day- continuous Endocrine: Other changes

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1221,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Sn)/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
EQSFAP 4,80,1975
TOXICOLOGY REVIEW
CRTXB2 34,301,2004
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
JTEHD6 7,281,2004
TOXICOLOGY REVIEW
FEREAC 72,41913,2007
TOXICOLOGY REVIEW
FEREAC 72,41913,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,151,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg(Sn)/m3 DTLVS* 3,258,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg(Sn)/m3, VLE 0.2 mg(Sn)/m3, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.4 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Sn)/m3,KZG- week 0.2 mg(Sn)/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air 10 hour time-weighted average 0.1 mg(Sn)/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in vinyl products to protect against mildew growth and stiffening by bacteria and fungi
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-139,1978


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOANDB Toxicology Annual. (New York, NY) 1974/75-79. Discontinued.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used in vinyl products to protect against mildew growth and stiffening by bacteria and fungi

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Organometallic
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

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