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Registry of Toxic Effects of Chemical Substances (RTECS)

Stannane, dibutyloxo-

RTECS #

WH7175000

CAS #

818-08-6

Updated

September 201

Molecular Weight

248.95

Molecular Formula

C8H18OSn

Synonyms

DBOT
Dibutyloxide of tin
Dibutyloxostannane
Dibutyloxotin
Dibutylstannane oxide
Dibutylstannium oxide
Dibutyltin oxide
Di-n-butyltin oxide
Di-n-butyl-zinn-oxyd (German)
Kyslicnik di-n-butylcinicity (Czech)
Tin, dibutyl-, oxide
Tin, dibutyloxo-

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeNTIS** OTS0555391
skin /rabbit 500 mg/24H mild85JCAE -,1248,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 19916 µg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXCYAC 85,149,1993

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 40 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
FCTXAV 7,47,1969
oral/rabbit lowest published lethal dose: 1500 mg/kgSAIGBL 15,3,1973
oral/rat lethal dose (50 percent kill): 44900 µg/kg85JCAE -,1248,1986
oral/rat lethal dose (50 percent kill): 50 mg/kgBehavioral: Somnolence (general depressed activity)NTIS** OTS0555391
skin/rabbit Lethal dose: >2 gm/kgLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0570737

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 31200 µg/kg/26W- intermittentBehavioral: Alteration of classical conditioning

Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count
GISAAA 42(4),14,1977

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg(Sn)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-short term exposure limit 0.2 mg(Sn)/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWEVHPAZ 4,61,1973

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 mg(Sn)/m3DTLVS* 3,258,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit-FRANCEVME 0.1 mg(Sn)/m3, VLE 0.2 mg(Sn)/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.4 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg(Sn)/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.004 ppm (0.02 mg(Sn)/m3), skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Sn)/m3;short term exposure limit 0.2 mg(Sn)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air10H time-weighted average 0.1 mg(Sn)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code T0245; Number of Industries 8; Total Number of Facilities 503; Number of Occupations 9; Total Number of Employees Exposed 4009; Total Number of Female Employees Exposed 691

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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