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Stannane, dibutylbis (lauroyloxy) -

RTECS #: WH7000000

CAS #: 77-58-7


UPDATE: May 2009 MW: 631.65 MF: C32H64O4Sn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Bis (lauroyloxy) di (n - butyl) stannane
  2. Butynorate
  3. Cata - Chek 820
  4. DBTL
  5. DXR 81
  6. Davainex
  7. Dibutyltin dilaurate
  8. Dibutyltin n - dodecanoate
  9. Dibutyltin laurate
  10. Dibutyl - zinn - dilaurat (German)
  11. Dibutylbis (laurato) tin
  12. Dibutylbis (lauroyloxy) tin
  13. Dibutylstannium dilaurate
  14. Fomrez sul - 4
  15. KS 20
  16. Kosmos 19
  17. Lankromark LT 173
  18. Laudran di - n - butylcinicity (Czech)
  19. Lauric acid, dibutylstannylene salt
  20. Lauric acid, dibutyltin deriv.
  21. Laustan - B
  22. Mark 1038
  1. Mark BT 11
  2. Mark BT 18
  3. Neostann U 100
  4. Ongrostab BLTM
  5. SM 2014C
  6. Stabilizer D - 22
  7. Stanclere DBTL
  8. Stannane, bis (dodecanoyloxy) di - n - butyl -
  9. Stannane, bis (lauroyloxy) dibutyl -
  10. Stannane, dibutylbis ( (1 - oxododecyl) oxy) -
  11. Stavincor 1200 SN
  12. TN 12
  13. TN 12 (catalyst)
  14. TVS Tin Lau
  15. TVS - TL 700
  16. Therm chek 820
  17. Thermolite T 12
  18. Tin dibutyl dilaurate
  19. Tin, dibutylbis (lauroyloxy) -
  20. Tin, di - n - butyl - , di (dodecanoate)
  21. Tinostat


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 28ZPAK -,230,1972
skin
rabbit
500 mg severe NTIS** OTS0555424


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 50,532 g/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXCYAC 85,149,1993


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 2,400 mg/m3 N/R MTPEEI (4),36,1995
inhalation
mouse
lethal concentration (50 percent kill): 150 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in bone marrow not included in above
STGNBT -,66,1999
intraperitoneal
mouse
lethal dose (50 percent kill): 180 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
MTPEEI (4),36,1995
intraperitoneal
rat
lowest published lethal dose: 85 mg/kg N/R BJPCAL 10,16,1955
intravenous
rat
lethal dose (50 percent kill): 33 mg/kg Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in bone marrow not included in above
STGNBT -,66,1999
oral
mouse
lethal dose (50 percent kill): 210 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
MTPEEI (4),36,1995
oral
rat
lethal dose (50 percent kill): 175 mg/kg N/R ARZNAD 10,44,1960
oral
rabbit
lethal dose (50 percent kill): 100 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Fatty liver degeneration

Blood: Pigmented or nucleated red blood cells
STGNBT -,66,1999
skin
rabbit
lethal dose : >2 gm/kg Gastrointestinal: Hypermotility, diarrhea

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555424


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 120 mg/kg/3 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 57,245,1991
oral
rat
lowest published toxic dose: 262 mg/kg/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 4,75,1981
oral
rat
lowest published toxic dose: 20 mg/kg/2 week- intermittent Endocrine: Changes in thymus weight IITOEF 16,645,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Sn)/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
EVHPAZ 4,61,1973
TOXICOLOGY REVIEW
EQSFAP 4,80,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg(Sn)/m3 DTLVS* 3,258,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg(Sn)/m3, VLE 0.2 mg(Sn)/m3, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.4 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Sn)/m3,KZG- week 0.2 mg(Sn)/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air 10 hour time-weighted average 0.1 mg(Sn)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83554;
Number of Industries 19;
Total Number of Facilities 413;
Number of Occupations 30;
Total Number of Employees Exposed 7,628
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83554;
Number of Industries 93;
Total Number of Facilities 8,868;
Number of Occupations 64;
Total Number of Employees Exposed 118,739;
Total Number of Female Employees Exposed 24,525


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as PVC heat stabilizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
IITOEF Immunopharmacology and Immunotoxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.9- 1987-
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia) No.1- 1993-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as PVC heat stabilizer

RTECS Compound Description:
   Organometallic
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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